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01-03-2018 | Original Article

The effect of the endotoxemia on the abomasal emptying rate in suckling lambs as shown by acetaminophen absorption test

Authors: A. A. Mozaffari, S. Jarakanibayat, D. Vosough, N. Eskandarzade, J. Tajic

Published in: Comparative Clinical Pathology | Issue 2/2018

Abstract

Abomasal hypomotility and a decreased rate of abomasal emptying are believed to play important roles in the etiopathogenesis of abomasal disorders in ruminants. The abomasal emptying rate is potentially influenced by several factors. Effect of endotoxins on contractility of smooth-muscle preparations from the bovine abomasal antrum has been evaluated, and the results showed that endotoxemia has an inhibitory effect on contractility of abomasal smooth-muscle fibers. To evaluate the effect of the endotoxemia on the abomasal emptying rate in suckling lambs, this study was conducted. This study was done on five suckling lambs in two phases. In phase 1 (control group), the first blood sample was obtained in 7 a.m. (time zero). Then a mixture of milk, barium sulfate 70%, and acetaminophen was administered orally to each lamb. Afterwards, blood samples were obtained each 15 min up to 4 h later. Phase 2 (treatment group) was similar to phase 1, but after the first blood sampling in time zero in 7 a.m., endotoxemia was induced by administration of commercial lipopolysaccharide at dose rate of 2 μg/kg. The rest of the processes of phase 2 were similar to phase 1. C_max, T_max, and area under concentration curve (AUC) of acetaminophen were measured in the control and treatment groups. The abomasal emptying rate was assessed by comparing C_max, T_max, and AUC of acetaminophen between the control and treatment groups. The data from the control and treatment groups were analyzed statistically by SPSS program, using one-way ANOVA. Results indicated that C_max, T_max, and AUC in the endotoxemic (treatment) group were significantly different compared with those in the control group, which means endotoxemia decreased abomasal emptying rate. Results of present study indicated that endotoxemia profoundly decreases the abomasal emptying rate in suckling lambs. Thus, administration of drugs which attenuate endotoxemia could enhance the abomasal emptying rate in endotoxemic animals.

Afshari G-R, Nouri M, Hassan EB, Mokhber-Dezfooli M-R, Constable PD (2009) Effect of parenteral administration of ivermectin and erythromycin on abomasal emptying rate in suckling calves. Am J Vet Res 70(4):527–531CrossRefPubMed

Burgstaller J, Wittek T, Smith GW (2017) Invited review: abomasal emptying in calves and its potential influence on gastrointestinal disease. J Dairy Sci 100(1):17–35CrossRefPubMed

Constable PD, Wittek T, Ahmed AF, Marshall TS, Sen I, Nouri M (2006) 2006 Abomasal pH and emptying rate in the calf and dairy cow and the effect of commonly administered therapeutic agents. Proceedings of the XXIV World Buiatrics Congress, Nice

Dunkel B, Corley KTT (2015) Pathophysiology, diagnosis and treatment of neonatal sepsis. Equine Vet Educ 27(2):92–98CrossRef

Fazeli M, Shomali T, Firouzi M, Ghane M (2012) Erythromycin enhances abomasal emptying in healthy unweaned lambs as shown by acetaminophen absorption test. J Vet Pharmacol Ther 35(4):410CrossRefPubMed

Heading RC, Nimmo J, Prescott L, Tothill P (1973) The dependence of paracetamol absorption on the rate of gastric emptying. Br J Pharmacol 47(2):415–421CrossRefPubMedPubMedCentral

Kaze C, Mevissen M, Hirsbrunner G, Steiner A (2004) Effect of endotoxins on contractility of smooth muscle preparations from the bovine abomasal antrum. Dtsch Tierarztl Wochenschr 111(1):28–35PubMed

Marshall TS, Constable PD, Crochik SS, Wittek T (2005) Determination of abomasal emptying rate in suckling calves by use of nuclear scintigraphy and acetaminophen absorption. Am J Vet Res 66(3):364–374CrossRefPubMed

Nouri M, Constable PD (2007) Effect of parenteral administration of erythromycin, tilmicosin, and tylosin on abomasal emptying rate in suckling calves. Am J Vet Res 68(12):1392–1398CrossRefPubMed

Nouri M, Hajikolaee M, Constable P, Omidi A (2008) Effect of erythromycin and gentamicin on abomasal emptying rate in suckling calves. J Vet Intern Med 22(1):196–201CrossRefPubMed

Osterbur K, Mann F, Kuroki K, DeClue A (2014) Multiple organ dysfunction syndrome in humans and animals. J Vet Intern Med 28(4):1141–1151CrossRefPubMedPubMedCentral

Rashnavadi M, Nouri M, Haji Hajikolaei MR, Najafzadeh H, Constable PD (2014) Effect of spiramycin and tulathromycin on abomasal emptying rate in milk-fed calves. Can J Vet Res 78(1):61–67PubMedPubMedCentral

Vlaminck K, Van Meirhaeghe H, Van Den Hende C, Oyaert W, Muylle E (1985) Effect of endotoxins on abomasal emptying in cattle. Dtsch Tierarztl Wochenschr 92(10):392–395PubMed

Wittek T, Constable PD (2005) Assessment of the effects of erythromycin, neostigmine, and metoclopramide on abomasal motility and emptying rate in calves. Am J Vet Res 66(3):545–552CrossRefPubMed

Wittek T, Tischer K, Gieseler T, Fürll M, Constable PD (2008) Effect of preoperative administration of erythromycin or flunixin meglumine on postoperative abomasal emptying rate in dairy cows undergoing surgical correction of left displacement of the abomasum. J Am Vet Med Assoc 232(3):418–423CrossRefPubMed

Title: The effect of the endotoxemia on the abomasal emptying rate in suckling lambs as shown by acetaminophen absorption test
Authors: A. A. Mozaffari
S. Jarakanibayat
D. Vosough
N. Eskandarzade
J. Tajic
Publication date: 01-03-2018
Publisher: Springer London
Published in: Comparative Clinical Pathology / Issue 2/2018
Print ISSN: 1618-5641
Electronic ISSN: 1618-565X
DOI: https://doi.org/10.1007/s00580-017-2585-1

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The effect of the endotoxemia on the abomasal emptying rate in suckling lambs as shown by acetaminophen absorption test

Abstract

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Abstract

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