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01-09-2007 | Original Article

The effect of ovariectomy on biomarkers of urogenital ageing in old versus young adult rats

Authors: Diaa E. E. Rizk, Mohamed A. Fahim, Hazem A. Hassan, Ahmed H. Al-Marzouqi, Gaber A. Ramadan, Soha S. Al-Kedrah, Layla S. Al-Ghafri

Published in: International Urogynecology Journal | Issue 9/2007

Abstract

The aim of this study was to compare the effects of ageing and ovariectomy on biomarkers of urogenital ageing in old and young-adult rats. Fisher 344 rats (18- and 3-months-old, n = 6 × 2) underwent ovariectomy. Age-matched sham animals received no intervention (n = 6 × 2). One month later, biomarkers of urogenital ageing were evaluated (light microscopic count of urethral and anal canal submucosal blood vessels, Western blot analysis of urethral, and anal canal submucosal collagen I and III and cytoplasmic p27^kip1 expression in the striated urethral and anal sphincters and levator ani and gel electrophoresis of isomyosin I proportion in these muscles) and compared in all groups (n = 24). All biomarkers of urogenital ageing studied were significantly increased in old compared to young-adult sham rats. Ovariectomy significantly increased these changes further in old versus young-adult rats with either smaller or larger differential effect than ageing compared to young-adult sham animals. Ovariectomy significantly exacerbates normative urogenital ageing changes in rats.

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Title: The effect of ovariectomy on biomarkers of urogenital ageing in old versus young adult rats
Authors: Diaa E. E. Rizk
Mohamed A. Fahim
Hazem A. Hassan
Ahmed H. Al-Marzouqi
Gaber A. Ramadan
Soha S. Al-Kedrah
Layla S. Al-Ghafri
Publication date: 01-09-2007
Publisher: Springer-Verlag
Published in: International Urogynecology Journal / Issue 9/2007
Print ISSN: 0937-3462
Electronic ISSN: 1433-3023
DOI: https://doi.org/10.1007/s00192-006-0278-4

At a glance: The STEP trials

Springer Medicine

The effect of ovariectomy on biomarkers of urogenital ageing in old versus young adult rats

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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