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International Journal of Colorectal Disease

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01-08-2018 | Original Article

The effect of marital status by age on patients with colorectal cancer over the past decades: a SEER-based analysis

Authors: Yang Feng, Weixing Dai, Yaqi Li, Shaobo Mo, Qingguo Li, Sanjun Cai

Published in: International Journal of Colorectal Disease | Issue 8/2018

Abstract

Objective

Marital status has been found as an independent prognostic factor for survival in colorectal cancer (CRC). However, it is unclear whether patients with different marital status have benefited the same from the treatment improvement.

Methods

We queried the Surveillance, Epidemiology, and End Results (SEER) 9 database for patients diagnosed with CRC from 1975 to 2009. Yearly survival data was presented with overlying loess smoothing lines, stratifying by marital status. We further referred to the SEER 18 database for patients diagnosed with CRC from 1973 to 2014. We also performed yearly data for stage proportion, surgery-performed rate, cancer-specific survival (CSS), and multivariate hazard ratio with overlying loess smoothing lines across all marital status.

Results

Five-year CSS of married, single, and separated/divorced patients showed remarkable increase since 1975; however, survival of widowed patients remained low and no survival gains were observed since 1990. The same trends persisted after stratifying patients by stage and gender. Married and widowed patients tended to have more localized disease and less distant disease compared with the other two groups, and married patients were more likely to receive surgery. Multivariate analysis revealed the hazard ratio of widowed patients dropped dramatically when including age at diagnosis.

Conclusions

Widowed patients have not benefited substantially from the remarkable treatment improvement over the past four decades, which may be the result of the older age of this particular group. This study is a wake-up call to the medical community for additional care for the widowed patients.

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Title: The effect of marital status by age on patients with colorectal cancer over the past decades: a SEER-based analysis
Authors: Yang Feng
Weixing Dai
Yaqi Li
Shaobo Mo
Qingguo Li
Sanjun Cai
Publication date: 01-08-2018
Publisher: Springer Berlin Heidelberg
Published in: International Journal of Colorectal Disease / Issue 8/2018
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI: https://doi.org/10.1007/s00384-018-3017-7

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

The effect of marital status by age on patients with colorectal cancer over the past decades: a SEER-based analysis

Abstract

Objective

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Objective

Methods

Results

Conclusions

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