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Published in: Clinical Rheumatology 7/2007

01-07-2007 | Case Report

The dynamism of cutaneous lupus erythematosus: mild discoid lupus erythematosus evolving into SLE with SCLE and treatment-resistant lupus panniculitis

Authors: Anna Wozniacka, Małgorzata Salamon, Aleksandra Lesiak, Daniel Paul McCauliffe, Anna Sysa-Jedrzejowska

Published in: Clinical Rheumatology | Issue 7/2007

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Abstract

We present a 47-year-old Caucasian female who initially presented with mild discoid lupus erythematosus that evolved into systemic lupus erythematosus with subacute cutaneous LE and treatment-recalcitrant lupus panniculitis. Conventional therapy with antimalarials, systemic steroids, azathioprine, cyclophosphamide, methotrexate, and pulse doses of methylprednisolone did not control the course of the disease. Cyclosporin-A treatment led to clinical improvement and maintained remission.
Literature
1.
go back to reference Gilliam JN, Sontheimer RD (1981) Distinctive cutaneous subsets in the spectrum of lupus erythematosus. J Am Acad Dermatol 4:471–475PubMedCrossRef Gilliam JN, Sontheimer RD (1981) Distinctive cutaneous subsets in the spectrum of lupus erythematosus. J Am Acad Dermatol 4:471–475PubMedCrossRef
2.
go back to reference Irgang S (1940) Lupus erythematosus profundus. Report of an example with clinical resemblance to Darier–Roussy sarcoid. Arch Dermatol Syph 42:97–108 Irgang S (1940) Lupus erythematosus profundus. Report of an example with clinical resemblance to Darier–Roussy sarcoid. Arch Dermatol Syph 42:97–108
3.
go back to reference Tuffanelli DL (1982) Lupus erythematosus (panniculitis) profundus: a classic revisited commentary and report of 22 cases. Hawaii Med J 41:394–397PubMed Tuffanelli DL (1982) Lupus erythematosus (panniculitis) profundus: a classic revisited commentary and report of 22 cases. Hawaii Med J 41:394–397PubMed
5.
go back to reference Jordan DR, McDonald H, Olberg B et al (1993) Orbital panniculitis as the initial manifestation of systemic lupus erythematosus. Ophthal Plast Reconstr Surg 9:71–75PubMedCrossRef Jordan DR, McDonald H, Olberg B et al (1993) Orbital panniculitis as the initial manifestation of systemic lupus erythematosus. Ophthal Plast Reconstr Surg 9:71–75PubMedCrossRef
6.
go back to reference Nowinski T, Bernardino V, Naidoff M et al (1982) Ocular involvement in lupus erythematosus profundus (panniculitis). Ophthalmology 89:1149–1154PubMed Nowinski T, Bernardino V, Naidoff M et al (1982) Ocular involvement in lupus erythematosus profundus (panniculitis). Ophthalmology 89:1149–1154PubMed
7.
go back to reference Tada J, Arata J, Katayama H (1991) Linear lupus erythematosus profundus in a child. J Am Acad Dermatol 24:871–874PubMed Tada J, Arata J, Katayama H (1991) Linear lupus erythematosus profundus in a child. J Am Acad Dermatol 24:871–874PubMed
9.
go back to reference Macjejewski W, Bandmann HJ (1979) Lupus erythematosus panniculitis (profoundus). Acta Derm Venereol Suppl (Stockh) 59:109–112 Macjejewski W, Bandmann HJ (1979) Lupus erythematosus panniculitis (profoundus). Acta Derm Venereol Suppl (Stockh) 59:109–112
10.
go back to reference Fox JN, Klapman MH, Rowe L (1987) Lupus profundus in children: treatment with hydroxychloroquine. J Am Acad Dermatol 16:839–844PubMed Fox JN, Klapman MH, Rowe L (1987) Lupus profundus in children: treatment with hydroxychloroquine. J Am Acad Dermatol 16:839–844PubMed
11.
go back to reference Chung HS, Hann SK (1997) Lupus panniculitis treated by combination therapy of hydroxychloroquine and quinacrine. J Dermatol 24:569–572PubMed Chung HS, Hann SK (1997) Lupus panniculitis treated by combination therapy of hydroxychloroquine and quinacrine. J Dermatol 24:569–572PubMed
12.
go back to reference Martens PB, Moder KG, Ahmed L (1999) Lupus panniculitis: clinical perspectives from a case series. J Rheumatol 26:68–72PubMed Martens PB, Moder KG, Ahmed L (1999) Lupus panniculitis: clinical perspectives from a case series. J Rheumatol 26:68–72PubMed
13.
go back to reference Khalfallah N, Azzabi S, Ben Hassine L et al (2003) Cutaneous lupus profundus. Tunis Med 81:134–139PubMed Khalfallah N, Azzabi S, Ben Hassine L et al (2003) Cutaneous lupus profundus. Tunis Med 81:134–139PubMed
14.
go back to reference Wimmershoff MB, Hohenleutner U, Landthaler M (2003) Discoid lupus erythematosus and lupus profundus in childhood: a report of two cases. Pediatr Dermatol 20:140–145PubMed Wimmershoff MB, Hohenleutner U, Landthaler M (2003) Discoid lupus erythematosus and lupus profundus in childhood: a report of two cases. Pediatr Dermatol 20:140–145PubMed
15.
go back to reference Yell JA, Burge SM (1993) Lupus erythematosus profundus treated with clobetasol propionate under a hydrocolloid dressing. Br J Dermatol 128:103PubMedCrossRef Yell JA, Burge SM (1993) Lupus erythematosus profundus treated with clobetasol propionate under a hydrocolloid dressing. Br J Dermatol 128:103PubMedCrossRef
16.
go back to reference Inuzuka M, Tomita K, Tokura Y, Takigawa M (2001) Lupus erythematosus profundus with unusual skin manifestation: subcutaneous nodules coexisting with eyelid plaques. J Dermatol 28:437–441PubMed Inuzuka M, Tomita K, Tokura Y, Takigawa M (2001) Lupus erythematosus profundus with unusual skin manifestation: subcutaneous nodules coexisting with eyelid plaques. J Dermatol 28:437–441PubMed
17.
go back to reference Morgan KW, Callen JP (2001) Calcifying lupus panniculitis in patients with subacute cutaneous lupus erythematosus: response to diltiazem and chloroquine. J Rheumatol 28:129–132 Morgan KW, Callen JP (2001) Calcifying lupus panniculitis in patients with subacute cutaneous lupus erythematosus: response to diltiazem and chloroquine. J Rheumatol 28:129–132
18.
go back to reference Yamada Y, Dekio S, Jidoi J, Ozasa S (1989) Lupus erythematosus profundus—report of a case treated with dapson. J Dermatol 16:379–382PubMed Yamada Y, Dekio S, Jidoi J, Ozasa S (1989) Lupus erythematosus profundus—report of a case treated with dapson. J Dermatol 16:379–382PubMed
19.
go back to reference Bohm I, Burns A, Schupp G, Bauer R (1998) ANCA-positive lupus erythematodes profundus. Successful therapy with low dosage dapson. Hautarzt 49:403–407PubMedCrossRef Bohm I, Burns A, Schupp G, Bauer R (1998) ANCA-positive lupus erythematodes profundus. Successful therapy with low dosage dapson. Hautarzt 49:403–407PubMedCrossRef
20.
21.
go back to reference Burrows NP, Walport MJ, Hammond AH et al (1991) Lupus erythematosus profundus with partial C4 deficiency responding to thalidomide. Br J Dermatol 125:62–67PubMedCrossRef Burrows NP, Walport MJ, Hammond AH et al (1991) Lupus erythematosus profundus with partial C4 deficiency responding to thalidomide. Br J Dermatol 125:62–67PubMedCrossRef
22.
go back to reference Peters MS, Su WP (1989) Lupus erythematosus panniculitis. Med Clin North Am 73:1113–1126PubMed Peters MS, Su WP (1989) Lupus erythematosus panniculitis. Med Clin North Am 73:1113–1126PubMed
23.
go back to reference Wang SW, Cheng TT (2005) Systemic lupus erythematosus with refractory hemolytic anemia effectively treated with cyclosporin A: a case report. Lupus 14:483–485PubMedCrossRef Wang SW, Cheng TT (2005) Systemic lupus erythematosus with refractory hemolytic anemia effectively treated with cyclosporin A: a case report. Lupus 14:483–485PubMedCrossRef
24.
go back to reference Saeki Y, Ohshima S, Kurimoto I et al (2000) Mainataining remission of lupus erythematosus profundus (LEP) with cyclosporin A. Lupus 9:390–392PubMedCrossRef Saeki Y, Ohshima S, Kurimoto I et al (2000) Mainataining remission of lupus erythematosus profundus (LEP) with cyclosporin A. Lupus 9:390–392PubMedCrossRef
25.
26.
go back to reference Hytiroglou P, Phelps RG, Wattenberg DJ et al (1992) Cytophagic histiocytic panniculitis; Molecular evidence for a clonal T cell disorder. J Am Acad Dermatol 27:333–336PubMedCrossRef Hytiroglou P, Phelps RG, Wattenberg DJ et al (1992) Cytophagic histiocytic panniculitis; Molecular evidence for a clonal T cell disorder. J Am Acad Dermatol 27:333–336PubMedCrossRef
27.
go back to reference Furman DA, Klee CB, Bievier BE, Burakoff SJ (1990) Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A. Proc Natl Acad Sci USA 89:3686–3690CrossRef Furman DA, Klee CB, Bievier BE, Burakoff SJ (1990) Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A. Proc Natl Acad Sci USA 89:3686–3690CrossRef
Metadata
Title
The dynamism of cutaneous lupus erythematosus: mild discoid lupus erythematosus evolving into SLE with SCLE and treatment-resistant lupus panniculitis
Authors
Anna Wozniacka
Małgorzata Salamon
Aleksandra Lesiak
Daniel Paul McCauliffe
Anna Sysa-Jedrzejowska
Publication date
01-07-2007
Publisher
Springer-Verlag
Published in
Clinical Rheumatology / Issue 7/2007
Print ISSN: 0770-3198
Electronic ISSN: 1434-9949
DOI
https://doi.org/10.1007/s10067-006-0310-6

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