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At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
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Published in: Trials 1/2013

Open Access 01-11-2013 | Poster presentation

The dog-leg design that can give clinical trials more power to their elbow

Authors: Richard Hooper, Liam Bourke

Published in: Trials | Special Issue 1/2013

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Excerpt

A cross-over design is contraindicated in trials of interventions with curative or deep-rooted effects, which are not washed out in participants randomised to receive the control after the experimental intervention. A parallel groups design with or without a baseline assessment of outcome is commonly employed instead. We focus here on the situation where the control is routine care, or where the experimental intervention is the control plus something else, so that wash-out in participants moving from the control to the experimental arm is not an issue. …
Metadata
Title
The dog-leg design that can give clinical trials more power to their elbow
Authors
Richard Hooper
Liam Bourke
Publication date
01-11-2013
Publisher
BioMed Central
Published in
Trials / Issue Special Issue 1/2013
Electronic ISSN: 1745-6215
DOI
https://doi.org/10.1186/1745-6215-14-S1-P16

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