Skip to main content
Top
Published in: BMC Public Health 1/2007

Open Access 01-12-2007 | Research article

The diagnosis and management of neuropathic pain in daily practice in Belgium: an observational study

Authors: Guy Hans, Etienne Masquelier, Patricia De Cock

Published in: BMC Public Health | Issue 1/2007

Login to get access

Abstract

Background

This open, multicentre, observational survey investigated how physicians diagnose neuropathic pain (NeP) by applying the Leeds Assessment of Neuropathic Symptoms and Signs (LANSS) scale, and how neuropathic pain conditions are managed in daily practice in Belgium.

Methods

Physicians were asked to complete the Leeds Assessment of Neuropathic Symptoms and Signs (LANSS) scale for diagnosing NeP, and to fill out a questionnaire regarding the management of NeP, together with a questionnaire evaluating the impact of pain on sleep and daily life. Data on 2,480 pain patients were obtained. A LANSS score ≥ 12 (meaning NeP is most probably present) was reported for 1,163 patients. Pathologies typically associated with NeP scored above 12 on the LANSS scale, contrary to pathologies generally considered as being of non-neuropathic origin.

Results

Over 90% of the patients with a LANSS score ≥ 12 reported that the pain impaired sleep. A high impact on social, family and professional life was also recorded. Additional examinations were performed in 89% of these patients. Most patients were taking multiple drugs, mainly paracetamol and non-steroidal anti-inflammatory drugs, indicating that physicians generally tend to follow treatment guidelines of chronic nociceptive pain, rather than the specific ones for NeP. Specific neuropathic guidelines rather recommend the use of anti-epileptic drugs, tricyclic antidepressants or weak opioids as first-line treatment.

Conclusion

In our survey, application of the LANSS scale lead to pronounced treatment simplification with fewer drug combinations. Awareness about NeP as well as its specific treatment recommendations should be raised among healthcare providers. We concluded that the LANSS screening scale is an interesting tool to assist physicians in detecting NeP patients in routine clinical care.
Appendix
Available only for authorised users
Literature
1.
go back to reference Merskey H: Logic, truth and language in concepts of pain. Qual Life Res. 1994, 3 (Suppl 1): S69-76. 10.1007/BF00433379.CrossRefPubMed Merskey H: Logic, truth and language in concepts of pain. Qual Life Res. 1994, 3 (Suppl 1): S69-76. 10.1007/BF00433379.CrossRefPubMed
2.
go back to reference Woolf CJ, Mannion RJ: Neuropathic pain: aetiology, symptoms, mechanisms, and management. Lancet. 1999, 353 (9168): 1959-1964. 10.1016/S0140-6736(99)01307-0.CrossRefPubMed Woolf CJ, Mannion RJ: Neuropathic pain: aetiology, symptoms, mechanisms, and management. Lancet. 1999, 353 (9168): 1959-1964. 10.1016/S0140-6736(99)01307-0.CrossRefPubMed
3.
go back to reference Bowsher D: Neurogenic pain syndromes and their management. British medical bulletin. 1991, 47 (3): 644-666.PubMed Bowsher D: Neurogenic pain syndromes and their management. British medical bulletin. 1991, 47 (3): 644-666.PubMed
4.
go back to reference Backonja MM, Serra J: Pharmacologic management part 1: better-studied neuropathic pain diseases. Pain Med. 2004, 5 (Suppl 1): S28-47. 10.1111/j.1526-4637.2004.04020.x.CrossRefPubMed Backonja MM, Serra J: Pharmacologic management part 1: better-studied neuropathic pain diseases. Pain Med. 2004, 5 (Suppl 1): S28-47. 10.1111/j.1526-4637.2004.04020.x.CrossRefPubMed
5.
go back to reference Gilron I, Bailey J, Weaver DF, Houlden RL: Patients' attitudes and prior treatments in neuropathic pain: a pilot study. Pain Res Manag. 2002, 7 (4): 199-203.CrossRefPubMed Gilron I, Bailey J, Weaver DF, Houlden RL: Patients' attitudes and prior treatments in neuropathic pain: a pilot study. Pain Res Manag. 2002, 7 (4): 199-203.CrossRefPubMed
6.
go back to reference Nicholson B, Verma S: Comorbidities in chronic neuropathic pain. Pain Med. 2004, 5 (Suppl 1): S9-S27. 10.1111/j.1526-4637.2004.04019.x.CrossRefPubMed Nicholson B, Verma S: Comorbidities in chronic neuropathic pain. Pain Med. 2004, 5 (Suppl 1): S9-S27. 10.1111/j.1526-4637.2004.04019.x.CrossRefPubMed
7.
go back to reference Attal N: Chronic neuropathic pain: mechanisms and treatment. The Clinical journal of pain. 2000, 16 (3 Suppl): S118-130.CrossRefPubMed Attal N: Chronic neuropathic pain: mechanisms and treatment. The Clinical journal of pain. 2000, 16 (3 Suppl): S118-130.CrossRefPubMed
8.
go back to reference Namaka M, Gramlich CR, Ruhlen D, Melanson M, Sutton I, Major J: A treatment algorithm for neuropathic pain. Clinical therapeutics. 2004, 26 (7): 951-979. 10.1016/S0149-2918(04)90171-3.CrossRefPubMed Namaka M, Gramlich CR, Ruhlen D, Melanson M, Sutton I, Major J: A treatment algorithm for neuropathic pain. Clinical therapeutics. 2004, 26 (7): 951-979. 10.1016/S0149-2918(04)90171-3.CrossRefPubMed
9.
go back to reference Ahmad M, Goucke CR: Management strategies for the treatment of neuropathic pain in the elderly. Drugs & aging. 2002, 19 (12): 929-945. 10.2165/00002512-200219120-00004.CrossRef Ahmad M, Goucke CR: Management strategies for the treatment of neuropathic pain in the elderly. Drugs & aging. 2002, 19 (12): 929-945. 10.2165/00002512-200219120-00004.CrossRef
10.
go back to reference Dworkin RH, Backonja M, Rowbotham MC, Allen RR, Argoff CR, Bennett GJ, Bushnell MC, Farrar JT, Galer BS, Haythornthwaite JA, et al: Advances in neuropathic pain: diagnosis, mechanisms, and treatment recommendations. Archives of neurology. 2003, 60 (11): 1524-1534. 10.1001/archneur.60.11.1524.CrossRefPubMed Dworkin RH, Backonja M, Rowbotham MC, Allen RR, Argoff CR, Bennett GJ, Bushnell MC, Farrar JT, Galer BS, Haythornthwaite JA, et al: Advances in neuropathic pain: diagnosis, mechanisms, and treatment recommendations. Archives of neurology. 2003, 60 (11): 1524-1534. 10.1001/archneur.60.11.1524.CrossRefPubMed
11.
go back to reference Bennett M: The LANSS Pain Scale: the Leeds assessment of neuropathic symptoms and signs. Pain. 2001, 92 (1–2): 147-157. 10.1016/S0304-3959(00)00482-6.CrossRefPubMed Bennett M: The LANSS Pain Scale: the Leeds assessment of neuropathic symptoms and signs. Pain. 2001, 92 (1–2): 147-157. 10.1016/S0304-3959(00)00482-6.CrossRefPubMed
12.
go back to reference Solak O, Metin M, Esme H, Solak O, Yaman M, Pekcolaklar A, Gurses A, Kavuncu V: Effectiveness of gabapentin in the treatment of chronic post-thoracotomy pain. Eur J Cardiothorac Surg. 2007 Solak O, Metin M, Esme H, Solak O, Yaman M, Pekcolaklar A, Gurses A, Kavuncu V: Effectiveness of gabapentin in the treatment of chronic post-thoracotomy pain. Eur J Cardiothorac Surg. 2007
13.
go back to reference Kaki AM, El-Yaski AZ, Youseif E: Identifying neuropathic pain among patients with chronic low-back pain: use of the Leeds Assessment of Neuropathic Symptoms and Signs pain scale. Regional anesthesia and pain medicine. 2005, 30 (5): 422-428. 10.1016/j.rapm.2005.05.013.PubMed Kaki AM, El-Yaski AZ, Youseif E: Identifying neuropathic pain among patients with chronic low-back pain: use of the Leeds Assessment of Neuropathic Symptoms and Signs pain scale. Regional anesthesia and pain medicine. 2005, 30 (5): 422-428. 10.1016/j.rapm.2005.05.013.PubMed
14.
go back to reference Pamuk ON, Yesil Y, Cakir N: Factors that affect the number of tender points in fibromyalgia and chronic widespread pain patients who did not meet the ACR 1990 criteria for fibromyalgia: are tender points a reflection of neuropathic pain?. Seminars in arthritis and rheumatism. 2006, 36 (2): 130-134. 10.1016/j.semarthrit.2006.05.002.CrossRefPubMed Pamuk ON, Yesil Y, Cakir N: Factors that affect the number of tender points in fibromyalgia and chronic widespread pain patients who did not meet the ACR 1990 criteria for fibromyalgia: are tender points a reflection of neuropathic pain?. Seminars in arthritis and rheumatism. 2006, 36 (2): 130-134. 10.1016/j.semarthrit.2006.05.002.CrossRefPubMed
15.
go back to reference Martinez-Lavin M, Lopez S, Medina M, Nava A: Use of the leeds assessment of neuropathic symptoms and signs questionnaire in patients with fibromyalgia. Seminars in arthritis and rheumatism. 2003, 32 (6): 407-411. 10.1053/sarh.2003.50017.CrossRefPubMed Martinez-Lavin M, Lopez S, Medina M, Nava A: Use of the leeds assessment of neuropathic symptoms and signs questionnaire in patients with fibromyalgia. Seminars in arthritis and rheumatism. 2003, 32 (6): 407-411. 10.1053/sarh.2003.50017.CrossRefPubMed
16.
go back to reference Potter J, Higginson IJ, Scadding JW, Quigley C: Identifying neuropathic pain in patients with head and neck cancer: use of the Leeds Assessment of Neuropathic Symptoms and Signs Scale. Journal of the Royal Society of Medicine. 2003, 96 (8): 379-383. 10.1258/jrsm.96.8.379.CrossRefPubMedPubMedCentral Potter J, Higginson IJ, Scadding JW, Quigley C: Identifying neuropathic pain in patients with head and neck cancer: use of the Leeds Assessment of Neuropathic Symptoms and Signs Scale. Journal of the Royal Society of Medicine. 2003, 96 (8): 379-383. 10.1258/jrsm.96.8.379.CrossRefPubMedPubMedCentral
17.
go back to reference Perez C, Galvez R, Insausti J, Bennett M, Ruiz M, Rejas J: [Linguistic adaptation and Spanish validation of the LANSS (Leeds Assessment of Neuropathic Symptoms and Signs) scale for the diagnosis of neuropathic pain]. Medicina clinica. 2006, 127 (13): 485-491. 10.1157/13093266.CrossRefPubMed Perez C, Galvez R, Insausti J, Bennett M, Ruiz M, Rejas J: [Linguistic adaptation and Spanish validation of the LANSS (Leeds Assessment of Neuropathic Symptoms and Signs) scale for the diagnosis of neuropathic pain]. Medicina clinica. 2006, 127 (13): 485-491. 10.1157/13093266.CrossRefPubMed
18.
go back to reference Yucel A, Senocak M, Kocasoy Orhan E, Cimen A, Ertas M: Results of the Leeds assessment of neuropathic symptoms and signs pain scale in Turkey: a validation study. J Pain. 2004, 5 (8): 427-432. 10.1016/j.jpain.2004.07.001.CrossRefPubMed Yucel A, Senocak M, Kocasoy Orhan E, Cimen A, Ertas M: Results of the Leeds assessment of neuropathic symptoms and signs pain scale in Turkey: a validation study. J Pain. 2004, 5 (8): 427-432. 10.1016/j.jpain.2004.07.001.CrossRefPubMed
19.
go back to reference Torrance N, Smith BH, Bennett MI, Lee AJ: The epidemiology of chronic pain of predominantly neuropathic origin. Results from a general population survey. J Pain. 2006, 7 (4): 281-289. 10.1016/j.jpain.2005.11.008.CrossRefPubMed Torrance N, Smith BH, Bennett MI, Lee AJ: The epidemiology of chronic pain of predominantly neuropathic origin. Results from a general population survey. J Pain. 2006, 7 (4): 281-289. 10.1016/j.jpain.2005.11.008.CrossRefPubMed
20.
go back to reference Berger A, Dukes EM, Oster G: Clinical characteristics and economic costs of patients with painful neuropathic disorders. J Pain. 2004, 5 (3): 143-149. 10.1016/j.jpain.2003.12.004.CrossRefPubMed Berger A, Dukes EM, Oster G: Clinical characteristics and economic costs of patients with painful neuropathic disorders. J Pain. 2004, 5 (3): 143-149. 10.1016/j.jpain.2003.12.004.CrossRefPubMed
21.
go back to reference Smith BH, Elliott AM, Chambers WA, Smith WC, Hannaford PC, Penny K: The impact of chronic pain in the community. Family practice. 2001, 18 (3): 292-299. 10.1093/fampra/18.3.292.CrossRefPubMed Smith BH, Elliott AM, Chambers WA, Smith WC, Hannaford PC, Penny K: The impact of chronic pain in the community. Family practice. 2001, 18 (3): 292-299. 10.1093/fampra/18.3.292.CrossRefPubMed
22.
go back to reference Lachaine J, Gordon A, Choiniere M, Collet JP, Dion D, Tarride JE: Painful neuropathic disorders: An analysis of the Regie de l'Assurance Maladie du Quebec database. Pain Res Manag. 2007, 12 (1): 31-37.CrossRefPubMedPubMedCentral Lachaine J, Gordon A, Choiniere M, Collet JP, Dion D, Tarride JE: Painful neuropathic disorders: An analysis of the Regie de l'Assurance Maladie du Quebec database. Pain Res Manag. 2007, 12 (1): 31-37.CrossRefPubMedPubMedCentral
23.
go back to reference Hansson P: Neuropathic pain: clinical characteristics and diagnostic workup. European journal of pain (London, England). 2002, 6 (Suppl A): 47-50. 10.1053/eujp.2001.0322.CrossRef Hansson P: Neuropathic pain: clinical characteristics and diagnostic workup. European journal of pain (London, England). 2002, 6 (Suppl A): 47-50. 10.1053/eujp.2001.0322.CrossRef
25.
go back to reference Mantyselka PT, Turunen JH, Ahonen RS, Kumpusalo EA: Chronic pain and poor self-rated health. Jama. 2003, 290 (18): 2435-2442. 10.1001/jama.290.18.2435.CrossRefPubMed Mantyselka PT, Turunen JH, Ahonen RS, Kumpusalo EA: Chronic pain and poor self-rated health. Jama. 2003, 290 (18): 2435-2442. 10.1001/jama.290.18.2435.CrossRefPubMed
26.
go back to reference Smith BH, Torrance N, Bennett MI, Lee AJ: Health and quality of life associated with chronic pain of predominantly neuropathic origin in the community. The Clinical journal of pain. 2007, 23 (2): 143-149. 10.1097/01.ajp.0000210956.31997.89.CrossRefPubMed Smith BH, Torrance N, Bennett MI, Lee AJ: Health and quality of life associated with chronic pain of predominantly neuropathic origin in the community. The Clinical journal of pain. 2007, 23 (2): 143-149. 10.1097/01.ajp.0000210956.31997.89.CrossRefPubMed
27.
go back to reference Menefee LA, Cohen MJ, Anderson WR, Doghramji K, Frank ED, Lee H: Sleep disturbance and nonmalignant chronic pain: a comprehensive review of the literature. Pain Med. 2000, 1 (2): 156-172. 10.1046/j.1526-4637.2000.00022.x.CrossRefPubMed Menefee LA, Cohen MJ, Anderson WR, Doghramji K, Frank ED, Lee H: Sleep disturbance and nonmalignant chronic pain: a comprehensive review of the literature. Pain Med. 2000, 1 (2): 156-172. 10.1046/j.1526-4637.2000.00022.x.CrossRefPubMed
28.
go back to reference Taylor DJ, Mallory LJ, Lichstein KL, Durrence HH, Riedel BW, Bush AJ: Comorbidity of chronic insomnia with medical problems. Sleep. 2007, 30 (2): 213-218.PubMed Taylor DJ, Mallory LJ, Lichstein KL, Durrence HH, Riedel BW, Bush AJ: Comorbidity of chronic insomnia with medical problems. Sleep. 2007, 30 (2): 213-218.PubMed
29.
go back to reference Smith MT, Perlis ML, Smith MS, Giles DE, Carmody TP: Sleep quality and presleep arousal in chronic pain. Journal of behavioral medicine. 2000, 23 (1): 1-13. 10.1023/A:1005444719169.CrossRefPubMed Smith MT, Perlis ML, Smith MS, Giles DE, Carmody TP: Sleep quality and presleep arousal in chronic pain. Journal of behavioral medicine. 2000, 23 (1): 1-13. 10.1023/A:1005444719169.CrossRefPubMed
30.
go back to reference Dinges DF, Pack F, Williams K, Gillen KA, Powell JW, Ott GE, Aptowicz C, Pack AI: Cumulative sleepiness, mood disturbance, and psychomotor vigilance performance decrements during a week of sleep restricted to 4–5 hours per night. Sleep. 1997, 20 (4): 267-277.PubMed Dinges DF, Pack F, Williams K, Gillen KA, Powell JW, Ott GE, Aptowicz C, Pack AI: Cumulative sleepiness, mood disturbance, and psychomotor vigilance performance decrements during a week of sleep restricted to 4–5 hours per night. Sleep. 1997, 20 (4): 267-277.PubMed
31.
go back to reference Hakki Onen S, Alloui A, Jourdan D, Eschalier A, Dubray C: Effects of rapid eye movement (REM) sleep deprivation on pain sensitivity in the rat. Brain Res. 2001, 900 (2): 261-267. 10.1016/S0006-8993(01)02320-4.CrossRefPubMed Hakki Onen S, Alloui A, Jourdan D, Eschalier A, Dubray C: Effects of rapid eye movement (REM) sleep deprivation on pain sensitivity in the rat. Brain Res. 2001, 900 (2): 261-267. 10.1016/S0006-8993(01)02320-4.CrossRefPubMed
32.
go back to reference Lentz MJ, Landis CA, Rothermel J, Shaver JL: Effects of selective slow wave sleep disruption on musculoskeletal pain and fatigue in middle aged women. The Journal of rheumatology. 1999, 26 (7): 1586-1592.PubMed Lentz MJ, Landis CA, Rothermel J, Shaver JL: Effects of selective slow wave sleep disruption on musculoskeletal pain and fatigue in middle aged women. The Journal of rheumatology. 1999, 26 (7): 1586-1592.PubMed
33.
go back to reference Akerstedt T, Nilsson PM: Sleep as restitution: an introduction. Journal of internal medicine. 2003, 254 (1): 6-12. 10.1046/j.1365-2796.2003.01195.x.CrossRefPubMed Akerstedt T, Nilsson PM: Sleep as restitution: an introduction. Journal of internal medicine. 2003, 254 (1): 6-12. 10.1046/j.1365-2796.2003.01195.x.CrossRefPubMed
34.
go back to reference Buysse DJ: Insomnia, depression and aging. Assessing sleep and mood interactions in older adults. Geriatrics. 2004, 59 (2): 47-51. quiz 52.PubMed Buysse DJ: Insomnia, depression and aging. Assessing sleep and mood interactions in older adults. Geriatrics. 2004, 59 (2): 47-51. quiz 52.PubMed
35.
go back to reference Rowbotham M, Harden N, Stacey B, Bernstein P, Magnus-Miller L: Gabapentin for the treatment of postherpetic neuralgia: a randomized controlled trial. Jama. 1998, 280 (21): 1837-1842. 10.1001/jama.280.21.1837.CrossRefPubMed Rowbotham M, Harden N, Stacey B, Bernstein P, Magnus-Miller L: Gabapentin for the treatment of postherpetic neuralgia: a randomized controlled trial. Jama. 1998, 280 (21): 1837-1842. 10.1001/jama.280.21.1837.CrossRefPubMed
36.
go back to reference Argoff CE: Pharmacologic management of chronic pain. The Journal of the American Osteopathic Association. 2002, 102 (9 Suppl 3): S21-27.PubMed Argoff CE: Pharmacologic management of chronic pain. The Journal of the American Osteopathic Association. 2002, 102 (9 Suppl 3): S21-27.PubMed
Metadata
Title
The diagnosis and management of neuropathic pain in daily practice in Belgium: an observational study
Authors
Guy Hans
Etienne Masquelier
Patricia De Cock
Publication date
01-12-2007
Publisher
BioMed Central
Published in
BMC Public Health / Issue 1/2007
Electronic ISSN: 1471-2458
DOI
https://doi.org/10.1186/1471-2458-7-170

Other articles of this Issue 1/2007

BMC Public Health 1/2007 Go to the issue