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01-06-2019 | Original Article

The correlation between gene polymorphisms of endothelial nitric oxide synthase and aneurismal subarachnoid hemorrhage

Authors: Zhang Zhe, Yang Bo

Published in: Neurosurgical Review | Issue 2/2019

Abstract

To discuss the association of the T786C and G894T polymorphisms of endothelial nitric oxide synthase (eNOS) with the occurrence and prognosis of aneurismal subarachnoid hemorrhage (aSAH). One hundred sixty-nine patients with aSAH were collected as the case group, which was divided into the good prognosis group and adverse prognosis group according to the condition 3 months after the treatment. One hundred fifty-six healthy volunteers were collected as the control group. The allele and genotype of T786C and G894T polymorphisms of eNOS were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The genotype and allele frequency of eNOS were compared between different groups. And then, the risk factors of aSAH occurrence and prognosis were analyzed by using the logistic regression model. Both the genotype and allele frequency distributions of T786C and G894T between the case group and control group were significantly different (P < 0.05). There were significant differences in the distribution of G894T and T786C allele frequency and G894T genotype between the good prognosis group and adverse prognosis group, and there was no difference in T786C genotype. The results of the logistic regression analysis indicated that T786C and G894T polymorphisms of eNOS were independent influencing factors on the occurrence of aSAH and the G894T polymorphism was also closely related to the prognosis. T786C and G894T polymorphisms of eNOS gene were correlated with the occurrence and prognosis of aSAH, and the G894T polymorphism might be an independent influencing factor.

Alexander S, Poloyac S, Hoffman L, Gallek M, Dianxu R, Balzer J, Kassam A, Conley Y (2009) Endothelial nitric oxide synthase tagging single nucleotide polymorphisms and recovery from aneurysmal subarachnoid hemorrhage. Biol Res Nurs 11:42–52CrossRefPubMedPubMedCentral

Aoki T, Nishimura M, Kataoka H, Ishibashi R, Nozaki K, Miyamoto S (2011) Complementary inhibition of cerebral aneurysm formation by eNOS and nNOS. Lab Investig 91:619–626CrossRefPubMed

Caranci F, Briganti F, Cirillo L, Leonardi M, Muto M (2013) Epidemiology and genetics of intracranial aneurysms. Eur J Radiol 82:1598–1605CrossRefPubMed

Chen XJ, Qiu CG, Kong XD, Ren SM, Dong JZ, Gu HP, Chen YW, Tao HL, Sarbesh J (2018) The association between an endothelial nitric oxide synthase gene polymorphism and coronary heart disease in young people and the underlying mechanism. Mol Med Rep 17:3928–3934PubMed

Hendrix P, Foreman PM, Harrigan MR, Fisher WR, Vyas NA, Lipsky RH, Lin M, Walters BC, Tubbs RS, Shoja MM, Pittet JF, Mathru M, Griessenauer CJ (2017) Endothelial nitric oxide synthase polymorphism is associated with delayed cerebral ischemia following aneurysmal subarachnoid hemorrhage. World Neurosurg 101:514–519CrossRefPubMed

Hendrix P, Foreman PM, Harrigan MR, Fisher WS, Vyas NA, Lipsky RH, Lin M, Walters BC, Tubbs RS, Shoja MM, Pittet J, Mathru M, Griessenauer CJ (2017) The role of endothelial nitric oxide synthase -786 T/C polymorphism in cardiac instability following aneurysmal subarachnoid hemorrhage. Nitric Oxide 71:52–56CrossRefPubMed

Ikenouchi-Sugita A, Yoshimura R, Kishi T, Umene-Nakano W, Hori H, Hayashi K, Katsuki A, Ueda N, Iwata N, Nakamura J (2011) Three polymorphisms of the eNOS gene and plasma levels of metabolites of nitric oxide in depressed Japanese patients: a preliminary report. Hum Psychopharmacol Clin Exp 26:531–534CrossRef

Jira M, Zavodna E, Honzikova N, Novakova Z, Vasku A, Izakovicova HL, Fiser B (2011) Association of eNOS gene polymorphisms T-786C and G894T with blood pressure variability in man. Physiol Res 60:193–197PubMed

Khurana VG, Sohni YR, Mangrum WI, McClelland RL, O'Kane DJ, Meyer FB, Meissner I (2003) Endothelial nitric oxide synthase T-786C single nucleotide polymorphism: a putative genetic marker differentiating small versus large ruptured intracranial aneurysms. Stroke 34:2555–2559CrossRefPubMed

10.

Khurana VG, Sohni YR, Mangrum WI, McClelland RL, O'Kane DJ, Meyer FB, Meissner I (2004) Endothelial nitric oxide synthase gene polymorphisms predict susceptibility to aneurysmal subarachnoid hemorrhage and cerebral vasospasm. J Cereb Blood Flow Metab 24:291–297CrossRefPubMed

11.

Kim TG, Kim NK, Baek MJ, Huh R, Chung SS, Choi JU, Yu SY (2011) The relationships between endothelial nitric oxide synthase polymorphisms and the formation of intracranial aneurysms in the Korean population. Neurosurg Focus 30:E23CrossRefPubMed

12.

Ko NU, Rajendran P, Kim H, Rutkowski M, Pawlikowska L, Kwok PY, Higashida RT, Lawton MT, Smith WS, Zaroff JG, Young WL (2008) Endothelial nitric oxide synthase polymorphism (-786T->C) and increased risk of angiographic vasospasm after aneurysmal subarachnoid hemorrhage. STROKE 39:1103–1108CrossRefPubMedPubMedCentral

13.

Koshy L, Easwer HV, Neetha NV, Natarajan C, Bhattacharya RN, Banerjee M (2008) Role of endothelial nitric oxide synthase gene polymorphisms in predicting aneurysmal subarachnoid hemorrhage in South Indian patients. Dis Markers 24:333–339CrossRefPubMedPubMedCentral

14.

Krischek B, Kasuya H, Akagawa H, Tajima A, Narita A, Onda H, Hori T, Inoue I (2006) Using endothelial nitric oxide synthase gene polymorphisms to identify intracranial aneurysms more prone to rupture in Japanese patients. J Neurosurg 105:717–722CrossRefPubMed

15.

Kumar A, Misra S, Kumar P, Sagar R, Prasad K, Pandit AK, Chakravarty K, Kathuria P, Yadav AK (2016) Association between endothelial nitric oxide synthase G894T gene polymorphism and risk of ischemic stroke in north Indian population: a case-control study. Neurol Res 38:575–579CrossRefPubMed

16.

Liu L, Huang X, Cai Y, Du J, Feng K, Lu H (2013) Association of G-894T and T-786C polymorphisms of endothelial nitric oxide synthase gene with sporadic intracranial aneurysms. Nan Fang Yi Ke Da Xue Xue Bao 33:1733–1737PubMed

17.

Ozum U, Bolat N, Gul E, Ozdemir O (2008) Endothelial nitric oxide synthase gene [G894T] polymorphism as a possible risk factor in aneurysmal subarachnoid haemorrhage. Acta Neurochir 150(62):57–61CrossRefPubMed

18.

Song MK, Kim MK, Kim TS, Joo SP, Park MS, Kim BC, Cho KH (2006) Endothelial nitric oxide gene T-786C polymorphism and subarachnoid hemorrhage in Korean population. J Korean Med Sci 21:922–926CrossRefPubMedPubMedCentral

19.

Starke RM, Kim GH, Komotar RJ, Hickman ZL, Black EM, Rosales MB, Kellner CP, Hahn DK, Otten ML, Edwards J, Wang T, Russo JJ, Mayer SA, Connolly EJ (2008) Endothelial nitric oxide synthase gene single-nucleotide polymorphism predicts cerebral vasospasm after aneurysmal subarachnoid hemorrhage. J Cereb Blood Flow Metab 28:1204–1211CrossRefPubMedPubMedCentral

20.

Triggle CR, Samuel SM, Ravishankar S, Marei I, Arunachalam G, Ding H (2012) The endothelium: influencing vascular smooth muscle in many ways. Can J Physiol Pharmacol 90:713–738CrossRefPubMed

21.

Xu L, Zhang SM (2010) The relationship between G894T polymorphism of endothelial nitric oxide synthase gene and spontaneous aneurismal subarachnoid hemorrhage. Chin J Neurosurgery 5:422–425

22.

Yang C, Qi ZY, Shao C, Xing WK, Wang Z (2015) Association between three eNOS polymorphisms and intracranial aneurysms risk: a meta-analysis. Medicine (Baltimore) 94:e452CrossRef

23.

Zhang Y, Yang W, Fan Z (2010) Prognosis of patients with aneurysmal subarachnoid hemorrhage. Chinese General Practice 15:1713–1715

24.

Zhu XL, Xu Y, Min M (2015) Correlation between aneurysmal subarachnoid hemorrhage and gene-polymorphisms of vascular endothelial growth factor. Chin J Clinical Neurosciences 2:008

25.

Zou FJ, Deng FM (2013) Correlation between eNOS polymorphism and cerebrovascular disease. Chin J Public Health 29(2):299–302

Title: The correlation between gene polymorphisms of endothelial nitric oxide synthase and aneurismal subarachnoid hemorrhage
Authors: Zhang Zhe
Yang Bo
Publication date: 01-06-2019
Publisher: Springer Berlin Heidelberg
Published in: Neurosurgical Review / Issue 2/2019
Print ISSN: 0344-5607
Electronic ISSN: 1437-2320
DOI: https://doi.org/10.1007/s10143-018-0992-7

At a glance: The STEP trials

Springer Medicine

The correlation between gene polymorphisms of endothelial nitric oxide synthase and aneurismal subarachnoid hemorrhage

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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