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Molecular Cancer
Published in: Molecular Cancer 1/2013

Open Access 01-12-2013 | Review

The complexity of bladder cancer: long noncoding RNAs are on the stage

Authors: Quanan Zhang, Mo Su, Guangming Lu, Jiangdong Wang

Published in: Molecular Cancer | Issue 1/2013

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Abstract

The mammalian genome encodes thousands of long noncoding RNAs (lncRNAs) and it is increasingly clear that lncRNAs are key regulators of cellular function and development. Gain and/or loss of function studies in cell culture indicate that lncRNAs can regulate gene transcription indirectly through the targeting and recruitment of chromatin-modifying complexes as well as directly at the transcriptional or posttranscriptional levels. LncRNA biology is attracting great attention in cancer research because dysregulated lncRNAs occur in a variety of cancers, placing lncRNAs on the stage of cancer genome research. We briefly describe the latest lncRNA biology and discuss the oncogenic lncRNAs involved in core pathways in bladder cancer and the application of lncRNAs to its diagnosis and targeted treatment. LncRNAs are becoming essential components of the gene regulatory circuitry in the complexity of bladder cancer.
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Metadata
Title
The complexity of bladder cancer: long noncoding RNAs are on the stage
Authors
Quanan Zhang
Mo Su
Guangming Lu
Jiangdong Wang
Publication date
01-12-2013
Publisher
BioMed Central
Published in
Molecular Cancer / Issue 1/2013
Electronic ISSN: 1476-4598
DOI
https://doi.org/10.1186/1476-4598-12-101

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