Skip to main content
Top
Published in: Clinical and Experimental Nephrology 6/2012

01-12-2012 | Editorial

The coming age of geriatric nephrology

Author: Enyu Imai

Published in: Clinical and Experimental Nephrology | Issue 6/2012

Login to get access

Excerpt

Baby boomers, aged around 60 years, and their children make two peaks in the demographic chart in Japan. The elderly population aged 65 and older comprised 17 % of the population in 2010 and will be rapidly increasing to 30 % by 2020, mainly because baby boomers will reach the age of 65 years old and the birth rate will be low [1]. An aging society increases the prevalence of chronic kidney diseases (CKD). The number of patients with CKD was estimated to be about 13 million (13 % of the adult population) in Japan [2], and the incidence of end-stage kidney disease, which occurs at a mean age of 68 years, was more than 35,000 in the last 5 years [3]. The elderly population 70 years and older accounted for 58 % of the CKD population [2]. The prevalence of proteinuria increases in association with aging, and 6.3 and 8.7 % of the adult male population had proteinuria in their 70s and 80s, respectively [2]. In females, individuals with proteinuria comprised 3.6 and 6.7 %, respectively [2]. Increasing numbers of elderly patients with kidney disease compel the field of geriatric nephrology to develop. However, limited data are available regarding pathological demographics in elderly patients. The Japanese Society of Nephrology launched the Japan Renal Biopsy Registry (JRBR) in 2007 to elucidate the pathological manifestation of Japanese renal diseases [4]. The registered biopsy record included more than 15,000 patients in 2012 and provided a great database resource for research [4]. …
Literature
2.
go back to reference Imai E, Horio M, Watanabe T, Iseki K, Yamagata K, Hara S, et al. Prevalence of chronic kidney disease in the Japanese general population. Clin Exp Nephrol. 2009;13:621–30.PubMedCrossRef Imai E, Horio M, Watanabe T, Iseki K, Yamagata K, Hara S, et al. Prevalence of chronic kidney disease in the Japanese general population. Clin Exp Nephrol. 2009;13:621–30.PubMedCrossRef
4.
go back to reference Sugiyama H, Yokoyama H, Sato H, Saito T, Kohda Y, Nishi S, Tsuruya K, Kiyomoto H, Iida H, Sasaki T, Higuchi M, Hattori M, Oka K, Kagami S, Nagata M, Kawamura T, Honda M, Fukasawa Y, Fukatsu A, Morozumi K, Yoshikawa N, Yuzawa Y, Matsuo S, Kiyohara Y, Joh K, Taguchi T. Committee for Standardization of Renal Pathological Diagnosis and Working Group for Renal Biopsy Database, Japanese Society of Nephrology, Tokyo, Japan: Japan Renal Biopsy Registry: the first nationwide, web-based, and prospective registry system of renal biopsies in Japan. Clin Exp Nephrol. 2011;15(4):493–503.PubMedCrossRef Sugiyama H, Yokoyama H, Sato H, Saito T, Kohda Y, Nishi S, Tsuruya K, Kiyomoto H, Iida H, Sasaki T, Higuchi M, Hattori M, Oka K, Kagami S, Nagata M, Kawamura T, Honda M, Fukasawa Y, Fukatsu A, Morozumi K, Yoshikawa N, Yuzawa Y, Matsuo S, Kiyohara Y, Joh K, Taguchi T. Committee for Standardization of Renal Pathological Diagnosis and Working Group for Renal Biopsy Database, Japanese Society of Nephrology, Tokyo, Japan: Japan Renal Biopsy Registry: the first nationwide, web-based, and prospective registry system of renal biopsies in Japan. Clin Exp Nephrol. 2011;15(4):493–503.PubMedCrossRef
5.
go back to reference Yokoyama H, Sugiyama H, Sato H, Taguchi T, Nagata M, Matsuo S, Makino H, Watanabe T, Saito T, Kiyohara Y, Nishi S, Iida H, Morozumi K, Fukatsu A, Sasaki T, Tsuruya K, Kohda Y, Higuchi M, Kiyomoto H, Goto S, Hattori M, Hataya H, Kagami S, Yoshikawa N, Fukasawa Y, Ueda Y, Kitamura H, Shimizu A, Oka K, Nakagawa N, Ito T, Uchida S, Furuichi K, Nakaya I, Umemura S, Hiromura K, Yoshimura M, Hirawa N, Shigematsu T, Fukagawa M, Hiramatsu M, Terada Y, Uemura O, Kawata T, Matsunaga A, Kuroki A, Mori Y, Mitsuiki K, Yoshida H. Renal disease in the elderly and the very elderly Japanese: analysis of the Japan Renal Biopsy Registry (J-RBR). Clin Exp Nephrol. 2012. doi:10.1007/s10157-012-0673-8. Yokoyama H, Sugiyama H, Sato H, Taguchi T, Nagata M, Matsuo S, Makino H, Watanabe T, Saito T, Kiyohara Y, Nishi S, Iida H, Morozumi K, Fukatsu A, Sasaki T, Tsuruya K, Kohda Y, Higuchi M, Kiyomoto H, Goto S, Hattori M, Hataya H, Kagami S, Yoshikawa N, Fukasawa Y, Ueda Y, Kitamura H, Shimizu A, Oka K, Nakagawa N, Ito T, Uchida S, Furuichi K, Nakaya I, Umemura S, Hiromura K, Yoshimura M, Hirawa N, Shigematsu T, Fukagawa M, Hiramatsu M, Terada Y, Uemura O, Kawata T, Matsunaga A, Kuroki A, Mori Y, Mitsuiki K, Yoshida H. Renal disease in the elderly and the very elderly Japanese: analysis of the Japan Renal Biopsy Registry (J-RBR). Clin Exp Nephrol. 2012. doi:10.​1007/​s10157-012-0673-8.
6.
go back to reference Nair R, Bell JM, Walker PD. Renal biopsy in patients aged 80 years and older. Am J Kidney Dis. 2004;44:618–26.PubMed Nair R, Bell JM, Walker PD. Renal biopsy in patients aged 80 years and older. Am J Kidney Dis. 2004;44:618–26.PubMed
7.
go back to reference Moutzouris DA, Herlitz L, Appel GB, Markowitz GS, Freudenthal B, Radhakrishnan J, D’Agati VD. Renal biopsy in the very elderly. Clin J Am Soc Nephrol. 2009;4:1073–82.PubMedCrossRef Moutzouris DA, Herlitz L, Appel GB, Markowitz GS, Freudenthal B, Radhakrishnan J, D’Agati VD. Renal biopsy in the very elderly. Clin J Am Soc Nephrol. 2009;4:1073–82.PubMedCrossRef
8.
go back to reference Beck LH Jr, Bonegio RG, Lambeau G, et al. M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy. N Engl J Med. 2009;361:11–21.PubMedCrossRef Beck LH Jr, Bonegio RG, Lambeau G, et al. M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy. N Engl J Med. 2009;361:11–21.PubMedCrossRef
9.
go back to reference Fujimoto S, Watts RA, Kobayashi S, Suzuki K, Jayne DR, Scott DG, Hashimoto H, Nunoi H. Comparison of the epidemiology of anti-neutrophil cytoplasmic antibody-associated vasculitis between Japan and the U.K. Rheumatology (Oxford). 2011;50(10):1916–20.CrossRef Fujimoto S, Watts RA, Kobayashi S, Suzuki K, Jayne DR, Scott DG, Hashimoto H, Nunoi H. Comparison of the epidemiology of anti-neutrophil cytoplasmic antibody-associated vasculitis between Japan and the U.K. Rheumatology (Oxford). 2011;50(10):1916–20.CrossRef
10.
go back to reference Ginsberg JM, Chang BS, Matarese RA, Garella S. Use of single voided urine samples to estimate quantitative proteinuria. N Engl J Med. 1983;309:1543–6.PubMedCrossRef Ginsberg JM, Chang BS, Matarese RA, Garella S. Use of single voided urine samples to estimate quantitative proteinuria. N Engl J Med. 1983;309:1543–6.PubMedCrossRef
11.
go back to reference Steinhauslin F, Wauters JP. Quantitation of proteinuria in kidney transplant patients: accuracy of the protein/creatinine ratio. Clin Nephrol. 1995;43:110–5.PubMed Steinhauslin F, Wauters JP. Quantitation of proteinuria in kidney transplant patients: accuracy of the protein/creatinine ratio. Clin Nephrol. 1995;43:110–5.PubMed
12.
go back to reference Brodby RA, Rohde RD, Zeev S, Pohl MA, Bain RP, Lewis EJ. The urine protein to creatinine ratio as a predictor of 24 hour urine protein excretion in type 1 diabetic patients with nephropathy. Am J Kidney Dis. 1995;26:904–9.CrossRef Brodby RA, Rohde RD, Zeev S, Pohl MA, Bain RP, Lewis EJ. The urine protein to creatinine ratio as a predictor of 24 hour urine protein excretion in type 1 diabetic patients with nephropathy. Am J Kidney Dis. 1995;26:904–9.CrossRef
13.
go back to reference Lane C, Brown M, Dunsmuir W, Kelly J, Mangos G. Can spot urine protein/creatinine ratio replace 24 h urine protein in usual clinical nephrology? Nephrology (Carlton). 2006;11(3):245–9.CrossRef Lane C, Brown M, Dunsmuir W, Kelly J, Mangos G. Can spot urine protein/creatinine ratio replace 24 h urine protein in usual clinical nephrology? Nephrology (Carlton). 2006;11(3):245–9.CrossRef
14.
go back to reference Wahbeh AM, Ewais MH, Elsharif ME. Comparison of 24-hour urinary protein and protein-to-creatinine ratio in the assessment of proteinuria. Saudi J Kidney Dis Transpl. 2009;20(3):443–7.PubMed Wahbeh AM, Ewais MH, Elsharif ME. Comparison of 24-hour urinary protein and protein-to-creatinine ratio in the assessment of proteinuria. Saudi J Kidney Dis Transpl. 2009;20(3):443–7.PubMed
Metadata
Title
The coming age of geriatric nephrology
Author
Enyu Imai
Publication date
01-12-2012
Publisher
Springer Japan
Published in
Clinical and Experimental Nephrology / Issue 6/2012
Print ISSN: 1342-1751
Electronic ISSN: 1437-7799
DOI
https://doi.org/10.1007/s10157-012-0693-4

Other articles of this Issue 6/2012

Clinical and Experimental Nephrology 6/2012 Go to the issue
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine