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Clinical Orthopaedics and Related Research®

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Open Access 01-09-2008 | Symposium: Molecular Genetics in Sarcoma

The Classic: Integration of Deoxyribonucleic Acid Specific for Rous Sarcoma Virus after Infection of Permissive and Nonpermissive Hosts

(RNA tumor viruses/reassociation kinetics/duck cells)

Authors: Harold E. Varmus, Peter K. Vogt, J. Michael Bishop

Published in: Clinical Orthopaedics and Related Research® | Issue 9/2008

Abstract

A relatively simple but stringent technique was developed to detect the integration of virus-specific DNA into the genomes of higher organisms. In both permissive (duck) and nonpermissive (mammalian) cells which normally contain no nucleotide sequences specific for Rous sarcoma virus, transformation by the virus results in the appearance of DNA specific for Rous sarcoma virus covalently integrated into strands of host-cell DNA containing reiterated sequences. Early after infection of mouse or duck cells by Rous sarcoma virus, unintegrated DNA specific for the virus can be demonstrated.

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Title: The Classic: Integration of Deoxyribonucleic Acid Specific for Rous Sarcoma Virus after Infection of Permissive and Nonpermissive Hosts
(RNA tumor viruses/reassociation kinetics/duck cells)
Authors: Harold E. Varmus
Peter K. Vogt
J. Michael Bishop
Publication date: 01-09-2008
Publisher: Springer-Verlag
Published in: Clinical Orthopaedics and Related Research® / Issue 9/2008
Print ISSN: 0009-921X
Electronic ISSN: 1528-1132
DOI: https://doi.org/10.1007/s11999-008-0355-8

At a glance: The STEP trials

Springer Medicine

The Classic: Integration of Deoxyribonucleic Acid Specific for Rous Sarcoma Virus after Infection of Permissive and Nonpermissive Hosts

(RNA tumor viruses/reassociation kinetics/duck cells)

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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