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Journal of Orthopaedic Science

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01-01-2015 | Original Article

The characteristics of scoliosis in Prader–Willi syndrome (PWS): analysis of 58 scoliosis patients with PWS

Authors: Yutaka Nakamura, Nobuyuki Murakami, Takahiro Iida, Satoru Ozeki, Satoshi Asano, Yutaka Nohara, Toshiro Nagai

Published in: Journal of Orthopaedic Science | Issue 1/2015

Abstract

Background

The purpose of this study was to compare the characteristics of scoliosis in Prader–Willi syndrome (PWS) patients versus idiopathic scoliosis (IS).

Methods

We identified 193 PWS patients. Scoliosis was found in 58 PWS patients, 39 of whom were treated with GH. Fifty-five IS patients were consecutively selected from an outpatient clinic. We investigated 113 patients (58 PWS group, 55 IS group) followed for a minimum of 2 years. The mean age was 17.9 and 16.1 years, respectively. Deformity was measured using Lenke classification, Cobb angle, thoracic kyphosis at T2–5 and T5–12, lumbar lordosis at T12–S1, and sagittal alignment at the C7 plumb line. BMI was also recorded.

Results

According to the Lenke system, patients were classified as (PWS group/IS group): Type 1 (8/26), Type 2 (1/4), Type 3 (3/15), Type 4 (1/0), Type 5 (32/8), and Type 6 (13/2). The average Cobb angles were 32.6° in the PWS and 35.4° in the IS. No significant differences were found for the thoracic kyphosis (T2–5, T5–12), lumbar lordosis (T12–S1) or C7 plumb line between the two groups. BMI was increased in the PWS group not treated previously with GH as compared with the IS group and the PWS group with GH.

Conclusions

Most PWS patients presented with lumbar or thoracolumbar curves (Type 5, 6), whereas IS patients typically had thoracic scoliosis (Type 1, 2, 3).

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Title: The characteristics of scoliosis in Prader–Willi syndrome (PWS): analysis of 58 scoliosis patients with PWS
Authors: Yutaka Nakamura
Nobuyuki Murakami
Takahiro Iida
Satoru Ozeki
Satoshi Asano
Yutaka Nohara
Toshiro Nagai
Publication date: 01-01-2015
Publisher: Springer Japan
Published in: Journal of Orthopaedic Science / Issue 1/2015
Print ISSN: 0949-2658
Electronic ISSN: 1436-2023
DOI: https://doi.org/10.1007/s00776-014-0651-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The characteristics of scoliosis in Prader–Willi syndrome (PWS): analysis of 58 scoliosis patients with PWS

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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