Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
Trials
Published in: Trials 1/2011

Open Access 01-12-2011 | Study protocol

The cameroon mobile phone sms (CAMPS) trial: a protocol for a randomized controlled trial of mobile phone text messaging versus usual care for improving adherence to highly active anti-retroviral therapy

Authors: Lawrence Mbuagbaw, Lahana Thabane, Pierre Ongolo-Zogo, Richard T Lester, Edward Mills, Jimmy Volmink, David Yondo, Marie José Essi, Renée-Cecile Bonono-Momnougui, Robert Mba, Jean Serge Ndongo, Francois C Nkoa, Henri Atangana Ondoa

Published in: Trials | Issue 1/2011

Login to get access

Abstract

Background

This trial aims at testing the efficacy of weekly reminder and motivational text messages, compared to usual care in improving adherence to Highly Active Antiretroviral Treatment in patients attending a clinic in Yaoundé, Cameroon.

Methods and Design

This is a single-centered randomized controlled single-blinded trial. A central computer generated randomization list will be generated using random block sizes. Allocation will be determined by sequentially numbered sealed opaque envelopes. 198 participants will either receive the mobile phone text message or usual care. Our hypothesis is that weekly motivational text messages can improve adherence to Highly Active Antiretroviral Treatment and other clinical outcomes in the control group by acting as a reminder, a cue to action and opening communication channels. Data will be collected at baseline, three months and six months. A blinded program secretary will send out text messages and record delivery.
Our primary outcomes are adherence measured by the visual analogue scale, self report, and pharmacy refill data. Our secondary outcomes are clinical: weight, body mass index, opportunistic infections, all cause mortality and retention; biological: Cluster Designation 4 count and viral load; and quality of life. Analysis will be by intention-to-treat. Covariates and subgroups will be taken into account.

Discussion

This trial investigates the potential of SMS motivational reminders to improve adherence to Highly Active Antiretroviral Treatment in Cameroon. The intervention targets non-adherence due to forgetfulness and other forms of non-adherence.

Trial Registration

Pan-African Clinical Trials Registry PACTR201011000261458
http://​clinicaltrials.​gov/​ NCT01247181
Appendix
Available only for authorised users
Literature
1.
Kaplan AW: Can the ubiquitous power of mobile phones be used to improve health outcomes in developing countries?. Global Health. 2006, 2: 9-10.1186/1744-8603-2-9.CrossRefPubMedPubMedCentral
2.
Lester RT, Gelmon L, Plummer FA: Cellphones: tightening the communication gap in resource-limited antiretroviral programmes?. AIDS. 2006, 20: 2242-2244. 10.1097/QAD.0b013e3280108508.CrossRefPubMed
3.
Mocroft A, Vella S, Benfield TL, Chiesi A, Miller V, Gargalianos P, d'Arminio Monforte A, Yust I, Bruun JN, Phillips AN, Lundgren JD: Changing patterns of mortality across Europe in patients infected with HIV-1. EuroSIDA Study Group Lancet. 1998, 28;352: 1725-30. 10.1016/S0140-6736(98)03201-2.
4.
5.
Gill CJ, Davidson HH, Jonathon LS, Donald MT, Lora LS: No Complacency about adherence to antiretroviral therapy in sub-saharan Africa. AIDS. 2005, 19: 1243-1249. 10.1097/01.aids.0000180094.04652.3b.CrossRefPubMed
6.
Paterson DL, Swindells S, Mohr J: Adherence to protease inhibitor therapy and outcomes in patients with HIV infection. Ann Intern Med. 2000, 133: 21-30.CrossRefPubMed
7.
Lester R, Mills E, Kariri A, Ritvo P, Chung M, Jack W, Habyarimana J, Karanja S, Barasa S, Nguti R, Estambale B, Ngugi E, Ball TB, Thabane L, Kimani J, Gelmon L, Ackers M, Plummer FA: The HAART cell phone adherence trial (WelTel Kenya1): a randomized controlled trial protocol. Trials. 2009, 10: 87-10.1186/1745-6215-10-87.CrossRefPubMedPubMedCentral
8.
De Costa A, Shet A, Kumarasamy N, Ashorn P, Eriksson B, Bogg L, Diwan V, team tHs: Design of a randomized trial to evaluate the influence of mobile phone reminders on adherence to first line antiretroviral treatment in South India - the HIVIND study protocol. BMC Med Res Methodol. 2010, 10: 25-10.1186/1471-2288-10-25.CrossRefPubMedPubMedCentral
9.
Lester RT, Ritvo P, Mills EJ, Kariri A, Karanja S, Chung MH, Jack W, Habyarimana J, Sadatsafavi M, Najafzadeh M, Marra CA, Estambale B, Ngugi E, Ball TB, Thabane L, Gelmon LJ, Kimani J, Ackers M, Plummer FA: Effects of a mobile phone short message service on antiretroviral treatment adherence in Kenya (WelTel Kenya 1): a randomized trial. Lancet. 2010,
10.
11.
Lester R, Karanja S: Mobile phones: exceptional tools for HIV/AIDS, health, and crisis management. Lancet Infect Dis. 2008, 8: 738-739. 10.1016/S1473-3099(08)70265-2.CrossRefPubMed
12.
Mukund Bahadur KC, Murrayb PJ: Cell Phone Short Messaging Service (SMS) for HIV/AIDS in South Africa: A literature review. Stud Health Technol Inform. 2010, 160: 530-534.PubMed
13.
Liu Q, Abba K, Alejandria MM, Balanag VM, Berba RP, Lansang MAD: Reminder systems and late patient tracers in the diagnosis and management of tuberculosis. Cochrane Database of Systematic Reviews. 2008, CD006594-Evidence Update published in June 2010, 4
14.
Wiener L, Riekert K, Ryder C, Wood LV: Assessing medication adherence in adolescents with HIV when electronic monitoring is not feasible. AIDS Patient Care STDS. 2004, 18: 527-538. 10.1089/apc.2004.18.527.CrossRefPubMed
15.
Leong KC, Chen WS, Leong KW, Mastura I, Mimi O, Sheikh MA, Zailinawati AH, Ng CJ, Phua KL, Teng CL: The use of text messaging to improve attendance in primary care: a randomized controlled trial. Fam Pract. 2006, 23: 699-705. 10.1093/fampra/cml044.CrossRefPubMed
16.
Dunbar PJ, Madigan D, Grohskopf LA, Revere D, Woodward J, Minstrell J, Frick PA, Simoni JM, Hooton TM: A two-way messaging system to enhance antiretroviral adherence. J Am Med Inform Assoc. 2003, 10: 11-15. 10.1197/jamia.M1047.CrossRefPubMedPubMedCentral
17.
Brianna S Fjeldsoe, Alison L Marshall, Yvette D Miller: Behavior Change Interventions Delivered by MobileTelephone Short-Message Service. Am J Prev Med. 2009, 36 (2): 165-173. 10.1016/j.amepre.2008.09.040.CrossRef
18.
19.
20.
21.
Simoni J, Kurth A, Pearson C, Pantalone D, Merrill J, Frick P: Self-Report Measures of Antiretroviral Therapy Adherence: A Review with Recommendations for HIV Research and Clinical Management. AIDS Behav. 10: 227-245. 10.1007/s10461-006-9078-6.
22.
Liu H, Golin CE, Miller LG, Hays RD, Beck CK, Sanandaji S, Christian J, Maldonado T, Duran D, Kaplan AH, Wenger NS: A Comparison Study of Multiple Measures of Adherence to HIV Protease Inhibitors. Ann Intern Med. 2001, 134: 968-977.CrossRefPubMed
23.
Martin S, Elliott-DeSorbo DK, Calabrese S, Wolters PL, Roby G, Brennan T, Wood LV: A comparison of adherence assessment methods utilized in the United States: perspectives of researchers, HIV-infected children, and their caregivers. AIDS Patient Care STDS. 2009, 23: 593-601. 10.1089/apc.2009.0021.CrossRefPubMedPubMedCentral
24.
Arnsten JH, Demas PA, Farzadegan H, Grant RW, Gourevitch MN, Chang CJ, Buono D, Eckholdt H, Howard AA, Schoenbaum EE: Antiretroviral therapy adherence and viral suppression in HIV-infected drug users: comparisonof self-report and electronic monitoring. Clin Infect Dis. 2001, 33: 1417-23. 10.1086/323201.CrossRefPubMedPubMedCentral
25.
26.
Abramson JH: WINPEPI (PEPI-for-Windows): computer programs for epidemiologists. Epidemiologic Perspectives & Innovations. 2004, 1: 6-CrossRef
27.
Strandbygaard U, Thomsen SF, Backer V: A daily SMS reminder increases adherence to asthma treatment: a three-month follow-up study. Respir Med. 2010, 104: 166-171. 10.1016/j.rmed.2009.10.003.CrossRefPubMed
28.
Schulz KF, Altman DG, Moher D: CONSORT 2010 Statement: Updated guidelines for reporting parallel group randomised trials. J Clin Epidemiol. 2010, 63: 834-840. 10.1016/j.jclinepi.2010.02.005.CrossRefPubMed
29.
Little RJA, Rubin DB: Statistical analysis with missing data. 1987, New York: John Wiley & Sons
30.
Mosoko JJ, Akam W, Weidle PJ, Brooks JT, Aweh AJ, Ebad M, Kinge TN, Vitek C, Raghunathan PL: Survival and adherence to antiretroviral therapy in an era of decreasing drug cost in Limbe, Cameroon. Proceedings of the 14th Conference on Retroviruses and Opportunistic Infections (CROI): 25-28. 2007, (Accessed 28 July 2010), February ; Los Angeles, California. Abstract 536http://​www.​retroconference.​org/​2007/​
31.
Charles Kouanfack, Christian Laurent, Gilles Peytavin, Yvette Mawamba Nkene, Claudine Essomba, Laura Ciaf, Maguy Ngolle, Eric Delaporte, Alexandra Calmy, Eitel Mpoudi-Ngole', SinataKoulla Shiro, for the French National Agency for Research on AIDS, 1274 Study Group: Adherence to Antiretroviral Therapy Assessed by Drug Level Monitoring and Self-Report in Cameroon. J Acquir Immune Def Syndr. 2008, 48: 216-219. 10.1097/QAI.0b013e3181743955.CrossRef
32.
Boyer S, Marcellin F, Ongolo-Zogo P, Abega SC, Nantchouang R, Spire B, Moatti JP: Financial barriers to HIV treatment in Yaoundé, Cameroon: first results of a national cross-sectional survey. Bull World Health Organ. 2009, 87: 279-287. 10.2471/BLT.07.049643.CrossRefPubMedPubMedCentral
33.
World Medical Organization: Declaration of Helsinki. BMJ. 1996, 313: 1448-1449.
34.
Reynolds NR, Testa MA, Su M, Chesney MA, Neidig JL, Frank I, Smith S, Ickovics J, Robbins GK: Telephone support to improve antiretroviral medication adherence: a multisite, randomized controlled trial. J Acquir Immune Defic Syndr. 2008, 47: 62-68. 10.1097/QAI.0b013e3181582d54.CrossRefPubMed
35.
Kunutsor S, Walley J, Katabira E, Muchuro S, Balidawa H, Namagala E, Ikoona E: Using mobile phones to improve clinic attendance amongst antiretroviral treatment cohort in rural Uganda: A cross-sectional and prospective study. AIDS Behav. 2010,
36.
Shet A, Arumugam K, Rodrigues R, Rajagopalan N, Shubha K, Raj T, D'Souza G, De Costa A: Designing a mobile phone-based intervention to promote adherence to antiretroviral therapy in South India. AIDS Behav. 2010, 14: 716-720. 10.1007/s10461-009-9658-3.CrossRefPubMed
37.
Maimen LA, Becker MH: The health belief model: origins and correlates in psychological theory. Health Educ Monogr. 1974, 2: 336-53.CrossRef
38.
Galavotti C, Pappas-DeLuca KA, Lansky A: Modeling and Reinforcement to Combat HIV: The MARCH Approach to Behavior Change. Am J Public Health. 2001, 91: 1602-1607. 10.2105/AJPH.91.10.1602.CrossRefPubMedPubMedCentral
Metadata
Title
The cameroon mobile phone sms (CAMPS) trial: a protocol for a randomized controlled trial of mobile phone text messaging versus usual care for improving adherence to highly active anti-retroviral therapy
Authors
Lawrence Mbuagbaw
Lahana Thabane
Pierre Ongolo-Zogo
Richard T Lester
Edward Mills
Jimmy Volmink
David Yondo
Marie José Essi
Renée-Cecile Bonono-Momnougui
Robert Mba
Jean Serge Ndongo
Francois C Nkoa
Henri Atangana Ondoa
Publication date
01-12-2011
Publisher
BioMed Central
Published in
Trials / Issue 1/2011
Electronic ISSN: 1745-6215
DOI
https://doi.org/10.1186/1745-6215-12-5

Other articles of this Issue 1/2011

Trials 1/2011 Go to the issue

Research

A post-trial survey to assess the impact of dissemination of results and unmasking on participants in a 13-year randomised controlled trial on age-related cataract

Study protocol

Culturally-Tailored Smoking Cessation for American Indians: Study protocol for a randomized controlled trial

Research

Stepped care treatment for depression and anxiety in primary care. a randomized controlled trial

Study protocol

Evaluating the effects of sevelamer carbonate on cardiovascular structure and function in chronic renal impairment in Birmingham: the CRIB-PHOS randomised controlled trial

Study protocol

Multi-professional clinical medication reviews in care homes for the elderly: study protocol for a randomised controlled trial with cost effectiveness analysis

Methodology

Comparisons against baseline within randomised groups are often used and can be highly misleading