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01-02-2013 | Maternal-Fetal Medicine

The burden of anaemia and associated factors in HIV positive Nigerian women

Authors: O. C. Ezechi, O. O. Kalejaiye, C. V. Gab-Okafor, D. A. Oladele, B. Oke, S. O. Ekama, N. N. Odunukwe, I. A. O. Ujah

Published in: Archives of Gynecology and Obstetrics | Issue 2/2013

Abstract

Background

Anaemia is the most common complication of pregnancy and a predictor of poor maternal and foetal outcomes. HIV infection is now recognized as one of the major contributors to anaemia in pregnancy. It is therefore important to determine the burden and risk factors of anaemia in maternal HIV infection in others to plan effective prevention strategies as well as optimize management outcomes.

Objective

To determine the prevalence and risk factors of anaemia in pregnant HIV positive Nigerians.

Methods

The prevalence and possible risk factors of anaemia were investigated in HIV positive pregnant Nigerian women at a large HIV treatment clinic in southwestern Nigeria using a cross-sectional design between January 2006 and December 2011.

Results

Nine hundred and eighty-five (42.5 %) women of 2,318 HIV positive pregnant women seen during the period were anaemic by WHO standard defined by haemoglobin <11 g/dl. Majority were of mild to moderate severity (97.9 %). Short inter birth interval (p = 0.002), presence of opportunistic infections (OIs), (p = 0.001), use of zidovudine containing regimen (p = 0.0005) and CD4 cell count <200 cells/mm³ (p = 0.001) were found to be independently associated with anaemia in HIV positive pregnant women after controlling for confounding variables.

Conclusion

Anaemia was found to be high at 42.5 % among the HIV positive women studied and was found to be independently associated with short inter birth interval, presence of OIs, advanced HIV disease and use of zidovudine containing HAART regimen.

Omigbodun AO (2004) Recent trends in the management of anaemia in pregnancy. Trop J Obstet Gynaecol 21(1):1–3

Aimakhu CO, Olayemi O (2003) Maternal haematocrit and pregnancy outcome in Nigerian women. West Afr J Med 22(1):18–21PubMed

Harrison KA (2001) Anaemia in pregnancy. In: Lawson JB, Harrison KA, Bergstrom S (eds) Maternity care in developing countries. RCOG Press, London, pp 112–128

Moyle G (2002) Anaemia in persons with HIV infections: prognostic markers and contributors to mortality. AIDS Rev 4(1):13–20PubMed

Omeregie R, Omokaro EU, Palmer O, Ogefere HO, Egbeobauwaye V, Adieghe JE et al (2009) Prevalence of anaemia among HIV-infected patients in Benin City, Nigeria. Tanzan J Health Res 11(1):1–4

Mocroft A, Kirk O, Barton SE, Dietrich M, Proenca R, Colebunders R et al (1999) Anaemia is an important marker for clinical prognosis in HIV infected patients from across Europe. EUROSIDA study group. AIDS 13:943–950PubMedCrossRef

Dairo MD, Lawoyin TO, Onadeko MO, Asekun-Olarinmoye EO, Adeniji AO (2005) HIV as an additional risk factors for anaemia in pregnancy: evidence from primary care level in Ibadan, Southwestern Nigeria. Afr J Med Med Sci 3:275–279

Dim CC, Onah HE (2007) The prevalence of anemia among pregnant women at booking in Enugu, South Eastern Nigeria. Med Gen Med 9(3):11

Uneke CJ, Duhlinska DD, Igbinedion EB (2007) Prevalence and public-health significance of HIV infection and anaemia among pregnant women attending antenatal clinics in south-eastern Nigeria. J Health Popul Nutr 25(3):328–335PubMed

10.

McDermott JM, Slutsker L, Steketee RW, Wirima JJ, Breman JG, Heymann DL (1996) Prospective assessment of mortality among a cohort of pregnant women in rural Malawi. Am J Trop Med Hyg 55(Suppl 1):66–70PubMed

11.

Cretton E, Bevan R (1991) Catabolism of 3 azido 3 deoxy thymidine in hepatocytes and liver microsomes with the formation of AMT which is toxic to human bone marrow cells. Mol Pharmacol 39:258–266PubMed

12.

Van den Broek NR, Letsky EA (2000) Etiology of anemia in pregnancy in south Malawi. Am J Clin Nutr 72(1):247S–256SPubMed

13.

Adesina O, Oladokun A, Akinyemi O et al (2011) Risk of anaemia in HIV positive pregnant women in Ibadan, south west Nigeria. Afr J Med Med Sci 40(1):67–73PubMed

14.

Msuya SE, Hussein TH, Uriyo J, Sam NE, Stray-Pedersen B (2011) Anaemia among pregnant women in Northern Tanzania: prevalence, risk factors and effect on perinatal outcomes. Tanzan J Health Res 13(1):40–49

15.

Antelman G, Msamanga GI, Spiegelman D, Urassa E, Narh R, Hunter DJ, Fawzi WW (2000) Nutritional factors and infectious disease contribute to anemia among pregnant women with HIV in Tanzania. J Nutr 130:1950–1957PubMed

16.

Sanusi RA, Badejo CA, Yusuf BO (2006) Measuring household food insecurity in selected local government areas of Lagos and Ibadan, Nigeria. Pak J Nutr 5(1):62–67CrossRef

17.

Singha G, Choi TJ, Nayak U, Gupta A, Nair S, Gupte N, Bulakh P, Sastry J, Deshmukh SD, Khandekar MM, Kulkarni V, Bhosale RA, Bharucha KE, Phadke MA, Kshirsagar AS, Bollinger RC (2007) Clinically significant anemia in HIV-infected pregnant women in india is not a major barrier to zidovudine use for prevention of maternal-to-child transmission. J Acquir Immune Defic Syndr 45(2):210–217CrossRef

18.

Moore RD, Forney D (2002) Anaemia in HIV-infected patient receiving highly active antiretroviral therapy. JAIDS 29(1):54–57PubMed

19.

Levine AM, Berhane K, Masri-Lavine L, Sanchez M, Young M, Augenbraun M, Cohen M, Anastos K, Newman M, Gange SJ, Watts H (2001) Prevalence and correlates of anemia in a large cohort of HIV-infected women: women’s interagency HIV study. J Acquir Immune Defic Syndr 26:28–35PubMed

20.

Semba RD, Shah N, Klein RS et al (2002) Prevalence and cumulative incidence of and risk factors for anemia in a multicenter cohort study of human immunodeficiency virus-infected and uninfected women. Clin Infect Dis 34:260–266PubMedCrossRef

21.

Curkendall SM, Richardson JT, Emoms MF, Fisher AE, Everhard F (2007) Incidence of anaemia among HIV infected patients treated with highly active antiretroviral therapy. HIV Med 8(8):483–490PubMedCrossRef

22.

Subbaraman R, Devaleenal B, Selvamuthu P, Yepthomi T, Solomon SS, Mayer KH, Kumarasamy N (2009) Factors associated with anaemia in HIV-infected individuals in southern India. Int J STD AIDS 20(7):489–492PubMedCrossRef

Title: The burden of anaemia and associated factors in HIV positive Nigerian women
Authors: O. C. Ezechi
O. O. Kalejaiye
C. V. Gab-Okafor
D. A. Oladele
B. Oke
S. O. Ekama
N. N. Odunukwe
I. A. O. Ujah
Publication date: 01-02-2013
Publisher: Springer-Verlag
Published in: Archives of Gynecology and Obstetrics / Issue 2/2013
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-012-2573-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The burden of anaemia and associated factors in HIV positive Nigerian women

Abstract

Background

Objective

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Objective

Methods

Results

Conclusion

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