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BMC Primary Care

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Open Access 01-12-2014 | Research article

The association of metabolic syndrome and its factors with gallstone disease

Authors: I-Ching Lin, Yu-Wen Yang, Mei-Feng Wu, Yi-Hui Yeh, Jenn-Chang Liou, Ying-Li Lin, Chih-Hsiang Chiang

Published in: BMC Primary Care | Issue 1/2014

Abstract

Background

To investigate the association between metabolic syndrome, including its factors, and gallstone disease (GSD) in a Taiwanese population.

Methods

We conducted a cross-sectional study during 2011 ~ 2012. A total of 12050 subjects who completed a questionnaire and underwent physical examination, laboratory tests and abdominal ultrasonography formed the study population.

Results

The prevalences of metabolic syndrome and gallstone disease were 24.09% and 6.16%. In an age- and sex-adjusted logistic regression model, metabolic syndrome was associated with gallstone disease (OR = 1.61; P < 0.0001). Age, abdominal obesity, and lower high-density lipoprotein cholesterol were associated with gallstone disease after adjusting for other factors. Females had a higher odds ratio than males in waist circumference for GSD, whereas males had a lower odds ratio than females in HDL-C for GSD.

Conclusions

The present study suggests that metabolic syndrome is related to gallstone disease. Waist circumference and high-density lipoprotein cholesterol are all associated with GSD. Men and women may possibly have different priorities and strategies to reduce the burden of GSD.

Grundy SM, Brewer HB, Cleeman JI, Smith SC, Lenfant C: Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. Circulation. 2004, 109: 433-438. 10.1161/01.CIR.0000111245.75752.C6.CrossRefPubMed

Grundy SM: Cholesterol gallstones: a fellow traveler with metabolic syndrome?. Am J Clin Nutr. 2004, 80: 1-2.PubMed

Mentes BB, Akin M, Irkörücü O, Tatlicioğlu E, Ferahköşe Z, Yildinm A, Maral I: Gastrointestinal quality of life in patients with symptomatic or asymptomatic cholelithiasis before and after laparoscopic cholecystectomy. Surg Endosc. 2001, 15: 1267-1272. 10.1007/s00464-001-9015-8.CrossRefPubMed

Liu CM, Tung TH, Chou P, Chen VT, Hsu CT, Chien WS, Lin YT, Lu HF, Shih HC, Liu JH: Clinical correlation of gallstone disease in a Chinese population in Taiwan: experience at Cheng Hsin General Hospital. World J Gastroenterol. 2006, 12: 1281-1286.CrossRefPubMedPubMedCentral

Chen CH, Huang MH, Yang JC, Nien CK, Etheredge GD, Yang CC, Yeh YH, Wu HS, Chou DA, Yueh SK: Prevalence and risk factors of gallstone disease in an adult population of Taiwan: an epidemiological survey. J Gastroenterol Hepatol. 2006, 21: 1737-1743. 10.1111/j.1440-1746.2006.04381.x.CrossRefPubMed

Kratzer W, Kachele V, Mason RA, Muche R, Hay B, Wiesneth M, Hill V, Beckh K, Adler G: Gallstone prevalence in relation to smoking, alcohol, coffee consumption, and nutrition. The Ulm Gallstone Study. Scand J Gastroenterol. 1997, 32: 953-958. 10.3109/00365529709011208.CrossRefPubMed

Amigo L, Zanlungo S, Mendoza H, Miquel JF, Nervi F: Risk factors and pathogenesis of cholesterol gallstones: state of the art. Eur Rev Med Pharmacol Sci. 1999, 3: 241-246.PubMed

Lin YM, Chen YH, Hu NC, Liao CS, Chen JH, Yang KC, Shih CH: The association of age, gender and metabolic factors with gallstone disease. The Gastroenterological Journal of Taiwan. 2011, 28: 11-18.

Méndez-Sánchez N, Chavez-Tapia NC, Motola-Kuba D, Sanchez-Lara K, Ponciano-Rodríguez G, Baptista H, Ramos MH, Uribe M: Metabolic syndrome as a risk factor for gallstone disease. World J Gastroenterol. 2005, 11: 1653-1657.CrossRefPubMedPubMedCentral

10.

Tsai TY, Cheng JF, Lai YM: Prevalence of metabolic syndrome and related factors in Taiwanese high-tech industry workers. Clinics. 2011, 66: 1531-1535. 10.1590/S1807-59322011000900004.CrossRefPubMedPubMedCentral

11.

Ministry of Health and Welfare: The definition of the metabolic syndrome in adults. Available online: http://www.hpa.gov.tw/BHPNet/Web/HealthTopic/TopicArticle.aspx?id=200712250123&Class=2&parentid=200712250023. Accessed 2014 JUL.30

12.

Hwang LC, Bai CH, Chen CJ: Prevalence of obesity and metabolic syndrome in Taiwan. J Formos Med Assoc. 2006, 105: 626-635. 10.1016/S0929-6646(09)60161-3.CrossRefPubMed

13.

Chen LY, Qiao QH, Zhang SC, Chen YH, Chao GQ, Fang LZ: Metabolic syndrome and gallstone disease. World J Gastroenterol. 2012, 18: 4215-4220. 10.3748/wjg.v18.i31.4215.CrossRefPubMedPubMedCentral

14.

Lirussi F, Nassuato G, Passera D, Toso S, Zalunardo B, Monica F, Virgilio C, Frasson F, Okolicsanyi L: Gallstone disease in an elderly population: the Silea study. Eur J Gastroenterol Hepatol. 1999, 11: 485-491. 10.1097/00042737-199905000-00004.CrossRefPubMed

15.

Tazuma S: Gallstone disease: epidemiology, pathogenesis, and classification of biliary stones (common bile duct and intrahepatic). Best Pract Res Clin Gastroenterol. 2006, 20: 1075-1083. 10.1016/j.bpg.2006.05.009.CrossRefPubMed

16.

Dixon JB, O’Brien PE: Obesity and the white blood cell count: changes with sustained weight loss. Obes Surg. 2006, 16: 251-257. 10.1381/096089206776116453.CrossRefPubMed

17.

Heaton KW, Braddon FE, Emmett PM, Mountford RA, Hughes AP, Bolton CH: Why do men get gallstones? Roles of abdominal fat and hyperinsulinemia. Eur J Gastroenterol Hepatol. 1991, 3: 745-751.

18.

Liew PL, Wang W, Lee YC, Huang MT, Lin YC, Lee WJ: Gallbladder disease among obese patients in Taiwan. Obes Surg. 2007, 17: 383-390. 10.1007/s11695-007-9068-4.CrossRefPubMed

19.

Karhapää P, Malkki M, Laakso M: Isolated low HDL cholesterol. An insulin-resistant state. Diabetes. 1994, 43: 411-417. 10.2337/diab.43.3.411.CrossRefPubMed

20.

Smelt AH: Triglycerides and gallstone formation. Clin Chim Acta. 2010, 411: 1625-1631. 10.1016/j.cca.2010.08.003.CrossRefPubMed

21.

Kovacs P, Kurtz U, Wittenburg H: Hepatic insulin resistance ties cholesterol gallstone formation and the metabolic syndrome. Ann Hepatol. 2008, 7: 262-264.PubMed

22.

Halldestam I, Enell EL, Kullman E, Borch K: Development of symptoms and complications in individuals with asymptomatic gallstones. Br J Surg. 2004, 91: 734-738. 10.1002/bjs.4547.CrossRefPubMed

23.

Ata N, Kucukazman M, Yavuz B, Bulus H, Dal K, Ertugrul DT, Yalcin AA, Polat M, Varol N, Akin KO, Karabag A, Nazligul Y: The metabolic syndrome is associated with complicated gallstone disease. Can J Gastroenterol. 2011, 25: 274-276.CrossRefPubMedPubMedCentral

The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2296/15/138/prepub

Title: The association of metabolic syndrome and its factors with gallstone disease
Authors: I-Ching Lin
Yu-Wen Yang
Mei-Feng Wu
Yi-Hui Yeh
Jenn-Chang Liou
Ying-Li Lin
Chih-Hsiang Chiang
Publication date: 01-12-2014
Publisher: BioMed Central
Published in: BMC Primary Care / Issue 1/2014
Electronic ISSN: 2731-4553
DOI: https://doi.org/10.1186/1471-2296-15-138

At a glance: The STEP trials

Springer Medicine

The association of metabolic syndrome and its factors with gallstone disease

Abstract

Background

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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