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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 1/2012

Open Access 01-12-2012 | Poster presentation

The association of autoantibodies expression, Th1/Th2 cytokines balance and IFNG polymorphism with histological phenotype of lupusnephritis

Authors: Kusworini Handono, Atma Gunawan, Singgih Wahono, Rulli Rosandi, Wivina, Natalina Mallo, Handono Kalim

Published in: Arthritis Research & Therapy | Special Issue 1/2012

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Excerpt

Racial differences were observed in clinical, serologic and histologic presentation of lupus nephritis (LN)[1]. It has been suggested that Th1/Th2 cytokines balance and IFNG polymorphism play important role in the development of different pathologic pattern of lupus nephritis (LN )[2‐4]. The objective of our study is to determine the association between autoantibodies expression, Th1/Th2 cytokines balance and IFNG polymorphisms with pathologic class of LN in Javanese patients. …
Literature
1.
Korbet SM, Schwartz MM, Evans J, et al: Severe lupus nephritis: racial differences in presentation and outcome. J Am Soc Nephrol. 2007, 18: 244-254. 10.1681/ASN.2006090992.CrossRefPubMed
2.
Chan RW-Y, Lai FM-M, Li EK-M, et al: Imbalance of Th1/Th2 transcription factors in patients with lupus nephritis. Rheumatol. 2006, 45: 951-957. 10.1093/rheumatology/kel029.CrossRef
3.
Miyake K, Nakashima H, Inoue Y, et al: Genetically determined interferon-γ production influences the histological phenotype of lupus nephritis. Rheumatol. 2002, 41: 518-24. 10.1093/rheumatology/41.5.518.CrossRef
4.
Uhm WS, Na K, Song G-W, Jung SS, Lee T, Park MH, Yoo DH: Cytokine balance in kidney tissue from lupus nephiritis patients. Rheumatol. 2003, 42: 935-938. 10.1093/rheumatology/keg255.CrossRef
Metadata
Title
The association of autoantibodies expression, Th1/Th2 cytokines balance and IFNG polymorphism with histological phenotype of lupusnephritis
Authors
Kusworini Handono
Atma Gunawan
Singgih Wahono
Rulli Rosandi
Wivina
Natalina Mallo
Handono Kalim
Publication date
01-12-2012
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue Special Issue 1/2012
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar3681

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