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BMC Medical Genetics
Published in: BMC Medical Genetics 1/2013

Open Access 01-12-2013 | Research article

The association between the angiotensin-converting enzyme-2 gene and blood pressure in a cohort study of adolescents

Authors: Lucile Malard, Lisa Kakinami, Jennifer O’Loughlin, Marie-Hélène Roy-Gagnon, Aurélie Labbe, Louise Pilote, Pavel Hamet, Johanne Tremblay, Gilles Paradis

Published in: BMC Medical Genetics | Issue 1/2013

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Abstract

Background

The Angiotensin-Converting Enzyme-2 (ACE2) gene, located on chromosome X, is believed to be implicated in blood pressure regulation. However the few studies that have examined this association have yielded mixed results. The objective of this study was to assess the association between tag single nucleotide polymorphisms (SNPs) in the angiotensin-converting enzyme-2 gene with blood pressure and blood pressure change in adolescents.

Methods

Participants in the Nicotine Dependence in Teens (NDIT) cohort study with blood or saliva samples and at least 3 blood pressure measurements over 5 years were included in the analytic sample (n = 555). Linear growth curve models stratified on sex and ethnicity were used to assess the association between four tag SNPs in the ACE2 gene and systolic (SBP) and diastolic blood pressure (DBP), and blood pressure change.

Results

In males of European descent, rs2074192 and rs233575 were significantly associated with SBP and DBP, and rs2158083 was associated with SBP. In French Canadian males, rs233575 and rs2158083 were significantly associated with DBP. Among females of European descent, rs2074192, rs233575, and rs2158083 were significantly associated with change in SBP over 5 years.

Conclusions

This is the first study to assess the association between the ACE2 gene with blood pressure and blood pressure change in a cohort of adolescents. Results indicate that several ACE2 gene SNPs are associated with blood pressure or blood pressure change in persons of European descent. However the therapeutic potential of these SNPs should be explored.
Appendix
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Metadata
Title
The association between the angiotensin-converting enzyme-2 gene and blood pressure in a cohort study of adolescents
Authors
Lucile Malard
Lisa Kakinami
Jennifer O’Loughlin
Marie-Hélène Roy-Gagnon
Aurélie Labbe
Louise Pilote
Pavel Hamet
Johanne Tremblay
Gilles Paradis
Publication date
01-12-2013
Publisher
BioMed Central
Published in
BMC Medical Genetics / Issue 1/2013
Electronic ISSN: 1471-2350
DOI
https://doi.org/10.1186/1471-2350-14-117

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