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Cancer Causes & Control

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01-04-2008 | Original Paper

The association between self-reported acrylamide intake and hemoglobin adducts as biomarkers of exposure

Authors: Birgitta Kütting, Wolfgang Uter, Hans Drexler

Published in: Cancer Causes & Control | Issue 3/2008

Abstract

Background

The validity of epidemiological studies assessing a lifetime cancer risk due to environmental factors, such as nutrition or smoking behavior strongly depends on the validity of the patient’s history.

Objectives

This study assesses whether a standardized questionnaire is a valid tool to identify exposure with acrylamide by relating the self-reported food and smoking history with a biomarker, namely hemoglobin-adduct levels of acrylamide.

Methods

Objective parameters of previous exposure, such as hemoglobin-adduct levels of acrylamide and of the smoking-specific acrylonitrile, respectively, were related to self-reported data in 1,008 volunteers of the general population in bivariate analyses and a multiple linear regression analysis using the log-transformed biomarker levels as outcome.

Results

Smoking was significantly associated with adduct levels of acrylamide (p < 0.0001) and had a main contribution to the internal burden with acrylamide. In cigarette smokers a strong correlation between the number of cigarettes smoked daily and the corresponding biomarkers was observed. Focusing on non-smokers (n = 828), a significant but weak correlation was found in bivariate analyses (Spearman rank correlation coefficient: 0.178 (95% CI: 0.089–0.268) in females and 0.168 (95% CI: 0.063–0.273) in males. A multiple linear regression analysis similarly yielded evidence of a significant association between the highest intake category and adduct levels; however, explained variability was very small (R² = 0.08).

Conclusion

Self-reported data concerning smoking behavior were highly valid, while self-reported food intake is apparently not as useful for estimating food-related acrylamide exposure.

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Title: The association between self-reported acrylamide intake and hemoglobin adducts as biomarkers of exposure
Authors: Birgitta Kütting
Wolfgang Uter
Hans Drexler
Publication date: 01-04-2008
Publisher: Springer Netherlands
Published in: Cancer Causes & Control / Issue 3/2008
Print ISSN: 0957-5243
Electronic ISSN: 1573-7225
DOI: https://doi.org/10.1007/s10552-007-9090-9

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