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International Urology and Nephrology
Published in: International Urology and Nephrology 1/2019

01-01-2019 | Nephrology - Review

The association between autosomal dominant polycystic kidney disease and cancer

Authors: Ke Sun, Dechao Xu, Changlin Mei

Published in: International Urology and Nephrology | Issue 1/2019

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Abstract

Autosomal dominant polycystic kidney disease (ADPKD) is considered as a tumor-like disease because there are many biological similarities between ADPKD and cancer. However, the commonalities between them are provocative, particularly under the conditions of recent clinical studies. In this paper, we review clinical studies about the association between cancer and ADPKD, and compare the biological characteristics between them, with focusing on cell proliferation, differentiation, migration, apoptosis, and polarity. With detailed literature reviewing, we believe that ADPKD patients have a higher risk of tumorigenesis and thus highly recommend being aware of tumorigenesis during follow-up in patients with ADPKD.
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Metadata
Title
The association between autosomal dominant polycystic kidney disease and cancer
Authors
Ke Sun
Dechao Xu
Changlin Mei
Publication date
01-01-2019
Publisher
Springer Netherlands
Published in
International Urology and Nephrology / Issue 1/2019
Print ISSN: 0301-1623
Electronic ISSN: 1573-2584
DOI
https://doi.org/10.1007/s11255-018-1951-5

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