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01-12-2021 | Thalassemia | Review

Fracture prevalence in thalassemia: a systematic review and meta-analysis

Authors: Nipith Charoenngam, Thanitsara Rittiphairoj, Ben Ponvilawan

Published in: Archives of Osteoporosis | Issue 1/2021

Abstract

Background

Multiple observational studies have reported high prevalence of fracture in patients with thalassemia. However, most of these studies have included limited number of patients, and only few of them have reported prevalence of fracture among patients with different types and severity of thalassemia.

Objective

This systematic review and meta-analysis was conducted to summarize all available data of fracture prevalence among patients with thalassemia.

Methods

A systematic review was conducted using EMBASE and MEDLINE databases from inception to June 2021 to determine studies that reported prevalence of fracture in thalassemia patients. The pooled prevalence with 95% confidence interval (95%CI) of fracture across studies was determined using a random-effect, generic inverse variance method.

Results

After two rounds of systematic review, a total of 25 studies with 4934 patients were included in the meta-analysis. The pooled prevalence of fracture among patients with thalassemia was 16% (95%CI, 15–17%, I² = 94.3%). The subgroup analyses showed that the pooled prevalence of fracture was 4% (95%CI, 2–6%; I² = 70.4%) among patients with alpha thalassemia, 17% (95%CI, 16–19%; I² = 93.2%) among patients with beta thalassemia, 18% (95%CI, 16–19%; I² = 89.0%) among patients with transfusion-dependent thalassemia, and 7% (95%CI, 4–10%; I² = 94.2%) among patients with non-transfusion-dependent thalassemia.

Conclusion

Fracture is common in patients with thalassemia, and may be more prevalent in beta thalassemia and transfusion-dependent thalassemia than in alpha thalassemia and non-transfusion-dependent thalassemia.

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Title: Fracture prevalence in thalassemia: a systematic review and meta-analysis
Authors: Nipith Charoenngam
Thanitsara Rittiphairoj
Ben Ponvilawan
Publication date: 01-12-2021
Publisher: Springer London
Keyword: Thalassemia
Published in: Archives of Osteoporosis / Issue 1/2021
Print ISSN: 1862-3522
Electronic ISSN: 1862-3514
DOI: https://doi.org/10.1007/s11657-021-01026-0

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Fracture prevalence in thalassemia: a systematic review and meta-analysis

Abstract

Background

Objective

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Objective

Methods

Results

Conclusion

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