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European Archives of Oto-Rhino-Laryngology
Published in: European Archives of Oto-Rhino-Laryngology 2/2016

01-02-2016 | Laryngology

Th1-, Th2-, and Th17-associated cytokine expression in hypopharyngeal carcinoma and clinical significance

Authors: Xuemei Chen, Junfu Wang, Rui Wang, Qinghong Su, Junwen Luan, Haiyan Huang, Peng Zhou, Jinsheng Liu, Xiaoqun Xu

Published in: European Archives of Oto-Rhino-Laryngology | Issue 2/2016

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Abstract

Th0 cells differentiate into Th1 or Th2 depending on multiple transcription factors acting on specific time points to regulate gene expression. Th17 cells, a subset of IL-17-producing T cells distinct from Th1 or Th2 cells, have been described as key players in inflammation and autoimmune diseases as well as cancer development. In the present study, 53 patients with hypopharyngeal cancer were included. The expression levels of Th1-, Th2- and Th17-associated cytokines in hypopharyngeal cancer tissues and pericarcinoma tissues were detected. The relationship between Th1, Th2, or Th17 infiltration and metastasis was studied. Our results showed that the mRNA and protein expressions of Th1 cytokines were lower, while the expressions of Th2 and Th17 cytokines were higher in tumor tissues, and the intensity of expression was strengthened with clinical stage increasing. Cancer tissues had higher level expressions of Th2 and Th17 cytokines than that of pericarcinoma tissues. From the above data, we speculated that high expressions of Th2- and Th17-associated cytokines in hypopharyngeal carcinoma may contribute to cancer development and metastasis.
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Metadata
Title
Th1-, Th2-, and Th17-associated cytokine expression in hypopharyngeal carcinoma and clinical significance
Authors
Xuemei Chen
Junfu Wang
Rui Wang
Qinghong Su
Junwen Luan
Haiyan Huang
Peng Zhou
Jinsheng Liu
Xiaoqun Xu
Publication date
01-02-2016
Publisher
Springer Berlin Heidelberg
Published in
European Archives of Oto-Rhino-Laryngology / Issue 2/2016
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI
https://doi.org/10.1007/s00405-015-3779-2

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