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Published in: Journal of Cardiothoracic Surgery 1/2023

Open Access 01-12-2023 | Tetralogy of Fallot | Research

Heterotopically-placed right ventricle-to-pulmonary artery conduit does not negatively affect outcomes

Authors: Khunthorn Kadeetham, Piya Samankatiwat

Published in: Journal of Cardiothoracic Surgery | Issue 1/2023

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Abstract

Objectives

Since the introduction of surgical implantation of conduit for right ventricle-to-pulmonary artery pathway reconstruction, there has been a number of studies on possible factors which might potentially affect conduit longevity, as well as patient’s reintervention-free and overall survival. Still, no definite consensual agreement could be made thus far. We aimed to compare conduit longevity, reintervention-free survival, and overall survival between patients with congenital heart diseases indicated for operations involving right ventricle-to-pulmonary artery pathway reconstruction whose conduits were placed heterotopically to those with orthotopically placed ones.

Materials and methods

We retrospectively collected data from electronic medical records of Ramathibodi hospital from 1st January 2005 to 31st December 2022. Patients with congenital heart diseases whose operations involved reconstruction of right ventricle-to-pulmonary artery continuity were included. Patients whose medical record data were significantly missing were excluded. Demographic data, operative, and postoperative details were collected and reviewed.

Results

There were 67 patients included in our study, with 25 receiving orthotopic and the other 42 receiving heterotopic conduit implantation. Conduit dysfunction-free, reintervention-free, and overall survival were not statistically different between both groups. There was 1 early and no late death up to the end date of our study.

Conclusions

Conduits placed on a heterotopic position did not result in worse longevity, reintervention-free survival, as well as overall survival when compared to conduits placed on an orthotopic position. This suggested that the less technically demanding heterotopic conduit placement could be recommended as an operation of choice for right ventricular outflow tract reconstruction.
Literature
1.
go back to reference Ross DN, Somerville J. Correction of pulmonary atresia with a homograft aortic valve. Lancet. 1966;2(7479):1446–7.CrossRefPubMed Ross DN, Somerville J. Correction of pulmonary atresia with a homograft aortic valve. Lancet. 1966;2(7479):1446–7.CrossRefPubMed
2.
go back to reference Rastelli GC, Ongley PA, Davis GD, Kirklin JW. Surgical repair for pulmonary valve atresia with coronary-pulmonary artery fistula: report of case. Mayo Clin Proc. 1965;40:521–7.PubMed Rastelli GC, Ongley PA, Davis GD, Kirklin JW. Surgical repair for pulmonary valve atresia with coronary-pulmonary artery fistula: report of case. Mayo Clin Proc. 1965;40:521–7.PubMed
3.
go back to reference Ruzmetov M, Geiss DM, Shah JJ, Fortuna RS, Welke KF. Does the homograft for RVOT reconstruction in ross: patients fare better than for non-Ross patients? A single-center experience. J Heart Valve Dis. 2015;24(4):478–83.PubMed Ruzmetov M, Geiss DM, Shah JJ, Fortuna RS, Welke KF. Does the homograft for RVOT reconstruction in ross: patients fare better than for non-Ross patients? A single-center experience. J Heart Valve Dis. 2015;24(4):478–83.PubMed
4.
go back to reference Selamet Tierney ES, Gersony WM, Altmann K, Solowiejczyk DE, Bevilacqua LM, Khan C, Krongrad E, Mosca RS, Quaegebeur JM, Apfel HD. Pulmonary position cryopreserved homografts: durability in pediatric Ross and non-Ross patients. J Thorac Cardiovasc Surg. 2005;130(2):282–6.CrossRefPubMed Selamet Tierney ES, Gersony WM, Altmann K, Solowiejczyk DE, Bevilacqua LM, Khan C, Krongrad E, Mosca RS, Quaegebeur JM, Apfel HD. Pulmonary position cryopreserved homografts: durability in pediatric Ross and non-Ross patients. J Thorac Cardiovasc Surg. 2005;130(2):282–6.CrossRefPubMed
5.
go back to reference Pearl JM, Laks H, Drinkwater DC Jr, Loo DK, George BL, Williams RG. Repair of conotruncal abnormalities with the use of the valved conduit: improved early and midterm results with the cryopreserved homograft. J Am Coll Cardiol. 1992;20(1):191–6.CrossRefPubMed Pearl JM, Laks H, Drinkwater DC Jr, Loo DK, George BL, Williams RG. Repair of conotruncal abnormalities with the use of the valved conduit: improved early and midterm results with the cryopreserved homograft. J Am Coll Cardiol. 1992;20(1):191–6.CrossRefPubMed
6.
go back to reference Vitanova K, Cleuziou J, Hörer J, Kasnar-Samprec J, Vogt M, Schreiber C, Lange R. Which type of conduit to choose for right ventricular outflow tract reconstruction in patients below 1 year of age? Eur J Cardiothorac Surg. 2014;46(6):961–6 (discussion 966).CrossRefPubMed Vitanova K, Cleuziou J, Hörer J, Kasnar-Samprec J, Vogt M, Schreiber C, Lange R. Which type of conduit to choose for right ventricular outflow tract reconstruction in patients below 1 year of age? Eur J Cardiothorac Surg. 2014;46(6):961–6 (discussion 966).CrossRefPubMed
7.
go back to reference Cocomello L, Meloni M, Rapetto F, Baquedano M, Ordoñez MV, Biglino G, Bucciarelli-Ducci C, Parry A, Stoica S, Caputo M. Long-term comparison between pulmonary homograft versus bioprosthesis for pulmonary valve replacement in tetralogy of fallot. J Am Heart Assoc. 2019;8(24): e013654.CrossRefPubMedPubMedCentral Cocomello L, Meloni M, Rapetto F, Baquedano M, Ordoñez MV, Biglino G, Bucciarelli-Ducci C, Parry A, Stoica S, Caputo M. Long-term comparison between pulmonary homograft versus bioprosthesis for pulmonary valve replacement in tetralogy of fallot. J Am Heart Assoc. 2019;8(24): e013654.CrossRefPubMedPubMedCentral
8.
go back to reference Zoghbi WA, Enriquez-Sarano M, Foster E, Grayburn PA, Kraft CD, Levine RA, Nihoyannopoulos P, Otto CM, Quinones MA, Rakowski H, Stewart WJ, Waggoner A, Weissman NJ, American Society of Echocardiography. Recommendations for evaluation of the severity of native valvular regurgitation with two-dimensional and Doppler echocardiography. J Am Soc Echocardiogr. 2003;16(7):777–802.CrossRefPubMed Zoghbi WA, Enriquez-Sarano M, Foster E, Grayburn PA, Kraft CD, Levine RA, Nihoyannopoulos P, Otto CM, Quinones MA, Rakowski H, Stewart WJ, Waggoner A, Weissman NJ, American Society of Echocardiography. Recommendations for evaluation of the severity of native valvular regurgitation with two-dimensional and Doppler echocardiography. J Am Soc Echocardiogr. 2003;16(7):777–802.CrossRefPubMed
9.
go back to reference Mohammadi S, Belli E, Martinovic I, Houyel L, Capderou A, Petit J, Planché C, Serraf A. Surgery for right ventricle to pulmonary artery conduit obstruction: risk factors for further reoperation. Eur J Cardiothorac Surg. 2005;28(2):217–22.CrossRefPubMed Mohammadi S, Belli E, Martinovic I, Houyel L, Capderou A, Petit J, Planché C, Serraf A. Surgery for right ventricle to pulmonary artery conduit obstruction: risk factors for further reoperation. Eur J Cardiothorac Surg. 2005;28(2):217–22.CrossRefPubMed
10.
go back to reference Bull C, Macartney FJ, Horvath P, Almeida R, Merrill W, Douglas J, Taylor JF, de Leval MR, Stark J. Evaluation of long-term results of homograft and heterograft valves in extracardiac conduits. J Thorac Cardiovasc Surg. 1987;94(1):12–9.CrossRefPubMed Bull C, Macartney FJ, Horvath P, Almeida R, Merrill W, Douglas J, Taylor JF, de Leval MR, Stark J. Evaluation of long-term results of homograft and heterograft valves in extracardiac conduits. J Thorac Cardiovasc Surg. 1987;94(1):12–9.CrossRefPubMed
11.
go back to reference Kouchoukos NT, Kirklin JW. Anatomy, dimensions, and terminology. In: Kirklin. 4th ed., vol. 1). Essay, Elsevier; 2013. p. 41–42. Kouchoukos NT, Kirklin JW. Anatomy, dimensions, and terminology. In: Kirklin. 4th ed., vol. 1). Essay, Elsevier; 2013. p. 41–42.
12.
go back to reference Sonntag SJ, Kütting M, Ghalati PF, Kaufmann T, Vázquez-Jiménez J, Steinseifer U, Vodiskar J. Effect of pulmonary conduit oversizing on hemodynamics in children. Int J Artif Organs. 2015;38(10):548–56.CrossRefPubMed Sonntag SJ, Kütting M, Ghalati PF, Kaufmann T, Vázquez-Jiménez J, Steinseifer U, Vodiskar J. Effect of pulmonary conduit oversizing on hemodynamics in children. Int J Artif Organs. 2015;38(10):548–56.CrossRefPubMed
13.
go back to reference Karamlou T, Ungerleider RM, Alsoufi B, Burch G, Silberbach M, Reller M, Shen I. Oversizing pulmonary homograft conduits does not significantly decrease allograft failure in children. Eur J Cardiothorac Surg. 2005;27(4):548–53.CrossRefPubMed Karamlou T, Ungerleider RM, Alsoufi B, Burch G, Silberbach M, Reller M, Shen I. Oversizing pulmonary homograft conduits does not significantly decrease allograft failure in children. Eur J Cardiothorac Surg. 2005;27(4):548–53.CrossRefPubMed
14.
go back to reference Askovich B, Hawkins JA, Sower CT, Minich LL, Tani LY, Stoddard G, Puchalski MD. Right ventricle-to-pulmonary artery conduit longevity: is it related to allograft size? Ann Thorac Surg. 2007;84(3):907–11 (discussion 911-2).CrossRefPubMed Askovich B, Hawkins JA, Sower CT, Minich LL, Tani LY, Stoddard G, Puchalski MD. Right ventricle-to-pulmonary artery conduit longevity: is it related to allograft size? Ann Thorac Surg. 2007;84(3):907–11 (discussion 911-2).CrossRefPubMed
15.
go back to reference Yuan SM, Mishaly D, Shinfeld A, Raanani E. Right ventricular outflow tract reconstruction: valved conduit of choice and clinical outcomes. J Cardiovasc Med (Hagerstown). 2008;9(4):327–37.CrossRefPubMed Yuan SM, Mishaly D, Shinfeld A, Raanani E. Right ventricular outflow tract reconstruction: valved conduit of choice and clinical outcomes. J Cardiovasc Med (Hagerstown). 2008;9(4):327–37.CrossRefPubMed
16.
go back to reference Ghez O, Tsang VT, Frigiola A, Coats L, Taylor A, Van Doorn C, Bonhoeffer P, De Leval M. Right ventricular outflow tract reconstruction for pulmonary regurgitation after repair of tetralogy of Fallot. Preliminary results. Eur J Cardiothorac Surg. 2007;31(4):654–8.CrossRefPubMed Ghez O, Tsang VT, Frigiola A, Coats L, Taylor A, Van Doorn C, Bonhoeffer P, De Leval M. Right ventricular outflow tract reconstruction for pulmonary regurgitation after repair of tetralogy of Fallot. Preliminary results. Eur J Cardiothorac Surg. 2007;31(4):654–8.CrossRefPubMed
17.
go back to reference Frigiola A, Tsang V, Nordmeyer J, Lurz P, van Doorn C, Taylor AM, Bonhoeffer P, de Leval M. Current approaches to pulmonary regurgitation. Eur J Cardiothorac Surg. 2008;34(3):576–80 (discussion 581-2).CrossRefPubMed Frigiola A, Tsang V, Nordmeyer J, Lurz P, van Doorn C, Taylor AM, Bonhoeffer P, de Leval M. Current approaches to pulmonary regurgitation. Eur J Cardiothorac Surg. 2008;34(3):576–80 (discussion 581-2).CrossRefPubMed
18.
go back to reference Wang X, Bakhuis W, Veen KM, Bogers AJJC, Etnel JRG, van Der Ven CCEM, Roos-Hesselink JW, Andrinopoulou ER, Takkenberg JJM. Outcomes after right ventricular outflow tract reconstruction with valve substitutes: a systematic review and meta-analysis. Front Cardiovasc Med. 2022;7(9): 897946.CrossRef Wang X, Bakhuis W, Veen KM, Bogers AJJC, Etnel JRG, van Der Ven CCEM, Roos-Hesselink JW, Andrinopoulou ER, Takkenberg JJM. Outcomes after right ventricular outflow tract reconstruction with valve substitutes: a systematic review and meta-analysis. Front Cardiovasc Med. 2022;7(9): 897946.CrossRef
19.
go back to reference Brown JW, Ruzmetov M, Rodefeld MD, Vijay P, Turrentine MW. Right ventricular outflow tract reconstruction with an allograft conduit in non-ross patients: risk factors for allograft dysfunction and failure. Ann Thorac Surg. 2005;80(2):655–63 (discussion 663).CrossRefPubMed Brown JW, Ruzmetov M, Rodefeld MD, Vijay P, Turrentine MW. Right ventricular outflow tract reconstruction with an allograft conduit in non-ross patients: risk factors for allograft dysfunction and failure. Ann Thorac Surg. 2005;80(2):655–63 (discussion 663).CrossRefPubMed
20.
go back to reference Saxena A, Salve GG, Betts K, Arora N, Cole AD, Sholler GF, Orr Y, Ayer JG, Winlaw DS. Outcomes following heterotopic placement of right ventricle to pulmonary artery conduits. World J Pediatr Congenit Heart Surg. 2021;12(2):220–9.CrossRefPubMed Saxena A, Salve GG, Betts K, Arora N, Cole AD, Sholler GF, Orr Y, Ayer JG, Winlaw DS. Outcomes following heterotopic placement of right ventricle to pulmonary artery conduits. World J Pediatr Congenit Heart Surg. 2021;12(2):220–9.CrossRefPubMed
21.
go back to reference Gerestein CG, Takkenberg JJ, Oei FB, Cromme-Dijkhuis AH, Spitaels SE, van Herwerden LA, Steyerberg EW, Bogers AJ. Right ventricular outflow tract reconstruction with an allograft conduit. Ann Thorac Surg. 2001;71(3):911–7 (discussion 917-8).CrossRefPubMed Gerestein CG, Takkenberg JJ, Oei FB, Cromme-Dijkhuis AH, Spitaels SE, van Herwerden LA, Steyerberg EW, Bogers AJ. Right ventricular outflow tract reconstruction with an allograft conduit. Ann Thorac Surg. 2001;71(3):911–7 (discussion 917-8).CrossRefPubMed
22.
go back to reference Junnil P, Cheanvechai C, Namchaisiri J, Saprungruang A, Thitivaraporn P, Chomvilailuk M, Benjacholamas V. Long-term course after pediatric right ventricular outflow tract reconstruction. Asian Cardiovasc Thorac Ann. 2021;29(6):483–9.CrossRefPubMed Junnil P, Cheanvechai C, Namchaisiri J, Saprungruang A, Thitivaraporn P, Chomvilailuk M, Benjacholamas V. Long-term course after pediatric right ventricular outflow tract reconstruction. Asian Cardiovasc Thorac Ann. 2021;29(6):483–9.CrossRefPubMed
23.
go back to reference Niemantsverdriet MB, Ottenkamp J, Gauvreau K, Del Nido PJ, Hazenkamp MG, Jenkins KJ. Determinants of right ventricular outflow tract conduit longevity: a multinational analysis. Congenit Heart Dis. 2008;3(3):176–84.CrossRefPubMed Niemantsverdriet MB, Ottenkamp J, Gauvreau K, Del Nido PJ, Hazenkamp MG, Jenkins KJ. Determinants of right ventricular outflow tract conduit longevity: a multinational analysis. Congenit Heart Dis. 2008;3(3):176–84.CrossRefPubMed
24.
go back to reference da Costa FDA, Etnel JRG, Torres R, Balbi Filho EM, Torres R, Calixto A, Mulinari LA. Decellularized allografts for right ventricular outflow tract reconstruction in children. World J Pediatr Congenit Heart Surg. 2017;8(5):605–12.CrossRefPubMed da Costa FDA, Etnel JRG, Torres R, Balbi Filho EM, Torres R, Calixto A, Mulinari LA. Decellularized allografts for right ventricular outflow tract reconstruction in children. World J Pediatr Congenit Heart Surg. 2017;8(5):605–12.CrossRefPubMed
25.
go back to reference Tudorache I, Calistru A, Baraki H, Meyer T, Höffler K, Sarikouch S, Bara C, Görler A, Hartung D, Hilfiker A, Haverich A, Cebotari S. Orthotopic replacement of aortic heart valves with tissue-engineered grafts. Tissue Eng Part A. 2013;19(15–16):1686–94.CrossRefPubMedPubMedCentral Tudorache I, Calistru A, Baraki H, Meyer T, Höffler K, Sarikouch S, Bara C, Görler A, Hartung D, Hilfiker A, Haverich A, Cebotari S. Orthotopic replacement of aortic heart valves with tissue-engineered grafts. Tissue Eng Part A. 2013;19(15–16):1686–94.CrossRefPubMedPubMedCentral
26.
go back to reference Yankah AC, Sievers HH, Bürsch JH, Radtcke W, Lange PE, Heintzen PH, Bernhard A. Orthotopic transplantation of aortic valve allografts. Early hemodynamic results. Thorac Cardiovasc Surg. 1984;32(2):92–5.CrossRefPubMed Yankah AC, Sievers HH, Bürsch JH, Radtcke W, Lange PE, Heintzen PH, Bernhard A. Orthotopic transplantation of aortic valve allografts. Early hemodynamic results. Thorac Cardiovasc Surg. 1984;32(2):92–5.CrossRefPubMed
27.
go back to reference Mitchell RN, Jonas RA, Schoen FJ. Pathology of explanted cryopreserved allograft heart valves: comparison with aortic valves from orthotopic heart transplants. J Thorac Cardiovasc Surg. 1998;115(1):118–27.CrossRefPubMed Mitchell RN, Jonas RA, Schoen FJ. Pathology of explanted cryopreserved allograft heart valves: comparison with aortic valves from orthotopic heart transplants. J Thorac Cardiovasc Surg. 1998;115(1):118–27.CrossRefPubMed
28.
go back to reference Wells WJ, Arroyo H Jr, Bremner RM, Wood J, Starnes VA. Homograft conduit failure in infants is not due to somatic outgrowth. J Thorac Cardiovasc Surg. 2002;124(1):88–96.CrossRefPubMed Wells WJ, Arroyo H Jr, Bremner RM, Wood J, Starnes VA. Homograft conduit failure in infants is not due to somatic outgrowth. J Thorac Cardiovasc Surg. 2002;124(1):88–96.CrossRefPubMed
29.
go back to reference Tweddell JS, Pelech AN, Frommelt PC, Mussatto KA, Wyman JD, Fedderly RT, Berger S, Frommelt MA, Lewis DA, Friedberg DZ, Thomas JP Jr, Sachdeva R, Litwin SB. Factors affecting longevity of homograft valves used in right ventricular outflow tract reconstruction for congenital heart disease. Circulation. 2000;102(19 Suppl 3):III130–5.PubMed Tweddell JS, Pelech AN, Frommelt PC, Mussatto KA, Wyman JD, Fedderly RT, Berger S, Frommelt MA, Lewis DA, Friedberg DZ, Thomas JP Jr, Sachdeva R, Litwin SB. Factors affecting longevity of homograft valves used in right ventricular outflow tract reconstruction for congenital heart disease. Circulation. 2000;102(19 Suppl 3):III130–5.PubMed
30.
go back to reference Salim MA, DiSessa TG, Alpert BS, Arheart KL, Novick WM, Watson DC Jr. The fate of homograft conduits in children with congenital heart disease: an angiographic study. Ann Thorac Surg. 1995;59(1):67–73.CrossRefPubMed Salim MA, DiSessa TG, Alpert BS, Arheart KL, Novick WM, Watson DC Jr. The fate of homograft conduits in children with congenital heart disease: an angiographic study. Ann Thorac Surg. 1995;59(1):67–73.CrossRefPubMed
Metadata
Title
Heterotopically-placed right ventricle-to-pulmonary artery conduit does not negatively affect outcomes
Authors
Khunthorn Kadeetham
Piya Samankatiwat
Publication date
01-12-2023
Publisher
BioMed Central
Published in
Journal of Cardiothoracic Surgery / Issue 1/2023
Electronic ISSN: 1749-8090
DOI
https://doi.org/10.1186/s13019-023-02362-7

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