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01-07-2010 | Experimental

Terlipressin versus adrenaline in an infant animal model of asphyxial cardiac arrest

Authors: Jesús López-Herce, Bárbara Fernández, Javier Urbano, Santiago Mencía, Maria J. Solana, Jimena del Castillo, Antonio Rodríguez-Núñez, Jose M. Bellón

Published in: Intensive Care Medicine | Issue 7/2010

Abstract

Purpose

The objective of this study was to compare the efficacy of terlipressin versus adrenaline in an experimental infant animal model of asphyxial cardiac arrest (ACA).

Design

Prospective randomised animal study.

Setting

Laboratory research department of a university hospital.

Methods

Seventy-one, 2-month-old, mechanically ventilated piglets were investigated. ACA was induced by removal of mechanical ventilation. Resuscitation was performed by means of manual external chest compressions and mechanical ventilation (CC + V). After 3 min of CC + V, return of spontaneous circulation (ROSC) was observed in 11 animals. The 60 piglets without ROSC were then randomised to the four study groups: adrenaline standard dose (Asd): 0.01 mg/kg/3 min; adrenaline high dose (Ahd): first dose (0.01 mg/kg) and subsequent doses (0.1 mg/kg/3 min); terlipressin (T): 20 µg/kg/6 min; and adrenaline standard dose plus terlipressin (Asd + T).

Measurements and results

The relationship between haemodynamic (heart rate, blood pressure, ECG rhythm, cardiac index), respiratory (end-tidal CO₂, blood gas analysis) and tissue perfusion (gastric intramucosal pH, central, cerebral and renal saturation) parameters and ROSC was analysed. ROSC was achieved in three piglets treated with Asd (20%), four treated with Ahd (26.7%), one treated with T (6.7%) and seven treated with Asd + T (46.7%) (P = 0.099). ROSC was achieved in 43.1% of animals with pulseless electrical activity, 30.4% with asystole and none with ventricular fibrillation (P = 0.0001).

Conclusion

In this infant animal model of cardiac arrest, there was a non-significant trend towards better outcome when terlipressin was combined with adrenaline compared with the use of adrenaline or terlipressin alone.

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Title: Terlipressin versus adrenaline in an infant animal model of asphyxial cardiac arrest
Authors: Jesús López-Herce
Bárbara Fernández
Javier Urbano
Santiago Mencía
Maria J. Solana
Jimena del Castillo
Antonio Rodríguez-Núñez
Jose M. Bellón
Publication date: 01-07-2010
Publisher: Springer-Verlag
Published in: Intensive Care Medicine / Issue 7/2010
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-010-1828-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Terlipressin versus adrenaline in an infant animal model of asphyxial cardiac arrest

Abstract

Purpose

Design

Setting

Methods

Measurements and results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Design

Setting

Methods

Measurements and results

Conclusion

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