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01-02-2016 | Original Article

Tenosynovial giant cell tumour (pigmented villonodular synovitis-)-like changes in periprosthetic interface membranes

Authors: Stephan Söder, Stefan Sesselmann, Thomas Aigner, Stephan Oehler, Abbas Agaimy

Published in: Virchows Archiv | Issue 2/2016

Abstract

Tenosynovial giant cell tumour (TSGCT; synonym, pigmented villonodular synovitis (PVNS)) is a rare low-grade mesenchymal neoplasm of either intra-articular or extra-articular origin. The etiopathogenesis of TSGCT is still uncertain, but recent studies showed a translocation involving colony-stimulating factor 1 (CSF-1) gene in a subset of cases. Histological features mimicking TSGCT can sometimes be encountered in periprosthetic interface membranes. To investigate the frequency and morphologic spectrum of this phenomenon, we conducted a systematic analysis of 477 periprosthetic interface membranes and performed immunohistochemical analysis on a subset of lesions compared to genuine TSGCT. In 26 of 477 periprosthetic membrane samples (5 %), at least some TSGCT-like features were found and 18 cases (4 %) strongly resembled it. Wear particles were detected in 100 % of the TSGCT-like lesions but only in 63.3 % of the whole cohort of periprosthetic membranes (p value <0.001). Immunohistochemistry comparing true TSGCT and TSGCT-like membranes showed similar inflammatory infiltrates with slightly elevated CD3+/CD8+ T lymphocytes and a slightly higher proliferation index in TSGCT samples. In conclusion, TSGCT-like changes in periprosthetic membranes likely represent exuberant fibrohistiocytic inflammatory response induced by wear particles and should be distinguished from genuine (neoplastic) TSGCT. Although TSGCT and TSGCT-like periprosthetic membranes represent different entities, their comparable morphology might reflect analogous morphogenesis.

Darling JM, Goldring SR, Harada Y, Handel ML, Glowacki J, Gravallese EM (1997) Multinucleated cells in pigmented villonodular synovitis and giant cell tumor of tendon sheath express features of osteoclasts. Am J Pathol 150:1383–1393PubMedPubMedCentral

Neale SD, Kristelly R, Gundle R, Quinn JM, Athanasou NA (1997) Giant cells in pigmented villo nodular synovitis express an osteoclast phenotype. J Clin Pathol 50:605–608CrossRefPubMedPubMedCentral

Durr HR, Stabler A, Maier M, Refior HJ (2001) Pigmented villonodular synovitis. Review of 20 cases. J Rheumatol 28:1620–1630PubMed

Miller WE (1982) Villonodular synovitis: pigmented and nonpigmented variations. South Med J 75:1084–1086CrossRefPubMed

Imakiire N, Fujino T, Morii T et al (2011) Malignant pigmented villonodular synovitis in the knee—report of a case with rapid clinical progression. Open Orthop J 5:13–16CrossRefPubMedPubMedCentral

Layfield LJ, Meloni-Ehrig A, Liu K, Shepard R, Harrelson JM (2000) Malignant giant cell tumor of synovium (malignant pigmented villonodular synovitis). Arch Pathol Lab Med 124:1636–1641PubMed

Li CF, Wang JW, Huang WW et al (2008) Malignant diffuse-type tenosynovial giant cell tumors: a series of 7 cases comparing with 24 benign lesions with review of the literature. Am J Surg Pathol 32:587–599CrossRefPubMed

Nielsen AL, Kiaer T (1989) Malignant giant cell tumor of synovium and locally destructive pigmented villonodular synovitis: ultrastructural and immunohistochemical study and review of the literature. Hum Pathol 20:765–771CrossRefPubMed

Chin KR, Brick GW (2002) Extraarticular pigmented villonodular synovitis: a cause for failed knee arthroscopy. Clin Orthop Relat Res 404:330–338CrossRefPubMed

10.

Mankin H, Trahan C, Hornicek F (2011) Pigmented villonodular synovitis of joints. J Surg Oncol 103:386–389CrossRefPubMed

11.

Ma X, Shi G, Xia C, Liu H, He J, Jin W (2013) Pigmented villonodular synovitis: a retrospective study of seventy five cases (eighty one joints). Int Orthop 37:1165–1170CrossRefPubMedPubMedCentral

12.

Aigner T, Oehler S, Niedobitek HG, Fassbender G, Kirchner T (1998) Iron deposits, cell populations and proliferative activity in pigmented villonodular synovitis of the knee joint. Verh Dtsch Ges Pathol 82:327–331PubMed

13.

Oehler S, Fassbender HG, Neureiter D, Meyer-Scholten C, Kirchner T, Aigner T (2000) Cell populations involved in pigmented villonodular synovitis of the knee. J Rheumatol 27:463–470PubMed

14.

Berger I, Rieker R, Ehemann V, Schmitz W, Autschbach F, Weckauf H (2005) Analysis of chromosomal imbalances by comparative genomic hybridisation of pigmented villonodular synovitis. Cancer Lett 220:231–236CrossRefPubMed

15.

West RB, Rubin BP, Miller MA et al (2006) A landscape effect in tenosynovial giant-cell tumor from activation of csf1 expression by a translocation in a minority of tumor cells. Proc Natl Acad Sci U S A 103:690–695CrossRefPubMedPubMedCentral

16.

Cupp JS, Miller MA, Montgomery KD et al (2007) Translocation and expression of csf1 in pigmented villonodular synovitis, tenosynovial giant cell tumor, rheumatoid arthritis and other reactive synovitides. Am J Surg Pathol 31:970–976CrossRefPubMed

17.

Rubin BP (2007) Tenosynovial giant cell tumor and pigmented villonodular synovitis: a proposal for unification of these clinically distinct but histologically and genetically identical lesions. Skelet Radiol 36:267–268CrossRef

18.

Ma XM, Xia CY, Fu PL, Liu HM, Yu HY, He J (2014) Unusual cases of pigmented villonodular synovitis after arthroplasty. Int J Clin Exp Med 7:1150–1154PubMedPubMedCentral

19.

Chung BJ, Park YB (2011) Pigmented villonodular synovitis after TKA associated with tibial component loosening. Orthopedics 34:e418–e420PubMed

20.

Karl LA, Sundstrom WR (1991) Prosthesis-induced synovitis simulating villonodular synovitis. Wis Med J 90:165–168PubMed

21.

Morawietz L, Classen RA, Schroder JH et al (2006) Proposal for a histopathological consensus classification of the periprosthetic interface membrane. J Clin Pathol 59:591–597CrossRefPubMedPubMedCentral

22.

Krenn V, Thomas P, Thomsen M et al (2014) Histopathological particle algorithm. Particle identification in the synovia and the slim. Z Rheumatol 73:639–649CrossRefPubMed

23.

Krenn V, Morawietz L, Perino G et al (2014) Revised histopathological consensus classification of joint implant related pathology. Pathol Res Pract 210:779–786CrossRefPubMed

24.

Lawrence T, Moskal JT, Diduch DR (1999) Analysis of routine histological evaluation of tissues removed during primary hip and knee arthroplasty. J Bone Joint Surg: Am Vol 81:926–931CrossRef

25.

Lin TH, Yao Z, Sato T et al (2014) Suppression of wear-particle-induced pro-inflammatory cytokine and chemokine production in macrophages via NF-kappaB decoy oligodeoxynucleotide: a preliminary report. Acta Biomater 10:3747–3755CrossRefPubMedPubMedCentral

26.

Paulus AC, Frenzel J, Ficklscherer A et al (2014) Polyethylene wear particles induce TLR 2 upregulation in the synovial layer of mice. J Mater Sci Mater Med 25:507–513CrossRefPubMed

27.

Yao Z, Keeney M, Lin TH et al (2014) Mutant monocyte chemoattractant protein 1 protein attenuates migration of and inflammatory cytokine release by macrophages exposed to orthopedic implant wear particles. J Biomed Mater Res Part A 102:3291–3297CrossRef

28.

Lin TH, Kao S, Sato T et al (2015) Exposure of polyethylene particles induces interferon-gamma expression in a natural killer T lymphocyte and dendritic cell coculture system in vitro: a preliminary study. J Biomed Mater Res Part A 103:71–75CrossRef

29.

Dahlen A, Broberg K, Domanski HA et al (2001) Analysis of the distribution and frequency of trisomy 7 in vivo in synovia from patients with osteoarthritis and pigmented villonodular synovitis. Cancer Genet Cytogenet 131:19–24CrossRefPubMed

30.

Ohjimi Y, Iwasaki H, Ishiguro M et al (1996) Short arm of chromosome 1 aberration recurrently found in pigmented villonodular synovitis. Cancer Genet Cytogenet 90:80–85CrossRefPubMed

31.

Fujikawa Y, Sabokbar A, Neale S, Athanasou NA (1996) Human osteoclast formation and bone resorption by monocytes and synovial macrophages in rheumatoid arthritis. Ann Rheum Dis 55:816–822CrossRefPubMedPubMedCentral

32.

Al-Saffar N, Revell PA (2000) Differential expression of transforming growth factor-alpha and macrophage colony-stimulating factor/colony-stimulating factor-1R (c-fins) by multinucleated giant cells involved in pathological bone resorption at the site of orthopaedic implants. J Orthop Res 18:800–807CrossRefPubMed

33.

Uchibori M, Nishida Y, Tabata I et al (2004) Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in pigmented villonodular synovitis suggests their potential role for joint destruction. J Rheumatol 31:110–119PubMed

Title: Tenosynovial giant cell tumour (pigmented villonodular synovitis-)-like changes in periprosthetic interface membranes
Authors: Stephan Söder
Stefan Sesselmann
Thomas Aigner
Stephan Oehler
Abbas Agaimy
Publication date: 01-02-2016
Publisher: Springer Berlin Heidelberg
Published in: Virchows Archiv / Issue 2/2016
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-015-1874-9

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Tenosynovial giant cell tumour (pigmented villonodular synovitis-)-like changes in periprosthetic interface membranes

Abstract

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Abstract

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