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Journal of Medical Case Reports

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Open Access 01-12-2009 | Case report

Tenecteplase for ST-elevation myocardial infarction in a patient treated with drotrecogin alfa (activated) for severe sepsis: a case report

Authors: Lillian Barra, Jeffrey Shum, J Geoffrey Pickering, Raymond Kao

Published in: Journal of Medical Case Reports | Issue 1/2009

Abstract

Introduction

Drotrecogin alfa (activated) (DrotAA), an activated protein C, promotes fibrinolysis in patients with severe sepsis. There are no reported cases or studies that address the diagnosis and treatment of myocardial infarction in septic patients treated with DrotAA.

Case presentation

A 59-year-old Caucasian man with septic shock secondary to community-acquired pneumonia treated with DrotAA, subsequently developed an ST-elevation myocardial infarction 12 hours after starting DrotAA. DrotAA was stopped and the patient was given tenecteplase thrombolysis resulting in complete resolution of ST-elevation and no adverse bleeding events. DrotAA was restarted to complete the 96-hour course. The sepsis resolved and the patient was discharged from hospital.

Conclusion

In patients with severe sepsis or septic shock complicated by myocardial infarction, it is difficult to determine if the myocardial infarction is an isolated event or caused by the sepsis process. The efficacy and safety of tenecteplase thrombolysis in septic patients treated with DrotAA need further study.

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Title: Tenecteplase for ST-elevation myocardial infarction in a patient treated with drotrecogin alfa (activated) for severe sepsis: a case report
Authors: Lillian Barra
Jeffrey Shum
J Geoffrey Pickering
Raymond Kao
Publication date: 01-12-2009
Publisher: BioMed Central
Published in: Journal of Medical Case Reports / Issue 1/2009
Electronic ISSN: 1752-1947
DOI: https://doi.org/10.1186/1752-1947-3-109

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Tenecteplase for ST-elevation myocardial infarction in a patient treated with drotrecogin alfa (activated) for severe sepsis: a case report

Abstract

Introduction

Case presentation

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Case presentation

Conclusion

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