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Head and Neck Pathology
Published in: Head and Neck Pathology 3/2011

01-09-2011 | Original Paper

Tenascin-C in Chronic Sclerosing Sialadenitis

Authors: Apostolos Epivatianos, Fotis Iordanidis, Dimitrios Andreadis, Savas Iordanidis, Athanasios Poulopoulos, Anastasios Markopoulos

Published in: Head and Neck Pathology | Issue 3/2011

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Abstract

Tenascin-C is an extracellular matrix glycoprotein that has been implicated in the development of fibrosis in certain chronic inflammatory/sclerosing conditions. This study was undertaken to expand our understanding of the processes involved in fibrosis that occurs in chronic sclerosing sialadenitis (CSS) by investigating the distribution of tenascin-C. Fifteen specimens of CSS with varying degrees of fibrosis and five normal submandibular glands were retrospectively examined immunohistochemically for the distribution of TNC. Linear deposition of TNC was found around collecting ducts in normal glands and around collecting ducts without surrounding fibrotic tissue in CSS; percentage incidences were not statistically different. In contrast, broader, band-like deposition of TNC was found in the fibrous tissue around collecting ducts in CSS with widespread degree of fibrosis compared to little or no fibrosis; the percentage incidence was statistically different. In addition, deposition of TNC was found around duct-like structures and extremely atrophic acini but, interestingly, however, was not found in fibrotic interlobular septa. The results of this investigation suggest that TNC is likely involved in the fibrosis that occurs around collecting ducts in CSS.
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Metadata
Title
Tenascin-C in Chronic Sclerosing Sialadenitis
Authors
Apostolos Epivatianos
Fotis Iordanidis
Dimitrios Andreadis
Savas Iordanidis
Athanasios Poulopoulos
Anastasios Markopoulos
Publication date
01-09-2011
Publisher
Springer US
Published in
Head and Neck Pathology / Issue 3/2011
Electronic ISSN: 1936-0568
DOI
https://doi.org/10.1007/s12105-011-0265-z

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