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BioPsychoSocial Medicine
Published in: BioPsychoSocial Medicine 1/2007

Open Access 01-12-2007 | Short report

Temporomandibular disorder is associated with a serotonin transporter gene polymorphism in the Japanese population

Authors: Kiyomi Ojima, Nagaoki Watanabe, Naoko Narita, Masaaki Narita

Published in: BioPsychoSocial Medicine | Issue 1/2007

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Abstract

Aims

Recent genetic studies have linked serotonin-related genetic polymorphisms with diverse disorders characterized by functional somatic symptoms, including chronic fatigue syndrome, irritable bowel syndrome, and premenstrual dysphoric disorder.

Methods

We investigated three serotonin-related genetic polymorphisms by screening genomic DNA of 36 temporomandibular disorder (TMD) patients.

Results

A significant increase of longer alleles (l and xl) was found in the TMD patients compared to the controls both by the genotype-wise and the allele-wise analyses (both p < 0.01 by χ2 test and Fisher's exact test).

Conclusion

Genetic factors that involve the serotonergic system may play a role in the pathogenesis of TMD.
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Metadata
Title
Temporomandibular disorder is associated with a serotonin transporter gene polymorphism in the Japanese population
Authors
Kiyomi Ojima
Nagaoki Watanabe
Naoko Narita
Masaaki Narita
Publication date
01-12-2007
Publisher
BioMed Central
Published in
BioPsychoSocial Medicine / Issue 1/2007
Electronic ISSN: 1751-0759
DOI
https://doi.org/10.1186/1751-0759-1-3

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