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Surgical Endoscopy
Published in: Surgical Endoscopy 9/2018

01-09-2018 | Dynamic Manuscript

Technique, safety, and feasibility of EUS-guided radiofrequency ablation in unresectable pancreatic cancer

Authors: Filippo Scopelliti, Antonio Pea, Rita Conigliaro, Giovanni Butturini, Isabella Frigerio, Paolo Regi, Alessandro Giardino, Helga Bertani, Marina Paini, Paolo Pederzoli, Roberto Girelli

Published in: Surgical Endoscopy | Issue 9/2018

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Abstract

Background and aims

Radiofrequency ablation (RFA) is a well-recognized local ablative technique applied in the treatment of different solid tumors. Intraoperative RFA has been used for non-metastatic unresectable pancreatic ductal adenocarcinoma (PDAC), showing increased overall survival in retrospective studies. A novel RFA probe has recently been developed, allowing RFA under endoscopic ultrasound (EUS) guidance. Aim of the present study was to assess the feasibility and safety of EUS-guided RFA for unresectable PDACs.

Methods

Patients with unresectable non-metastatic PDAC were included in the study following neoadjuvant chemotherapy. EUS-guided RFA was performed using a novel monopolar 18-gauge electrode with a sharp conical 1 cm tip for energy delivery. Pre- and post-procedural clinical and radiological data were prospectively collected.

Results

Ten consecutive patients with unresectable PDAC were enrolled. The procedure was successful in all cases and no major adverse events were observed. A delineated hypodense ablated area within the tumor was observed at the 30-day CT scan in all cases.

Conclusions

EUS-guided RFA is a feasible and safe minimally invasive procedure for patients with unresectable PDAC. Further studies are warranted to demonstrate the impact of EUS-guided RFA on disease progression and overall survival.
Appendix
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Metadata
Title
Technique, safety, and feasibility of EUS-guided radiofrequency ablation in unresectable pancreatic cancer
Authors
Filippo Scopelliti
Antonio Pea
Rita Conigliaro
Giovanni Butturini
Isabella Frigerio
Paolo Regi
Alessandro Giardino
Helga Bertani
Marina Paini
Paolo Pederzoli
Roberto Girelli
Publication date
01-09-2018
Publisher
Springer US
Published in
Surgical Endoscopy / Issue 9/2018
Print ISSN: 0930-2794
Electronic ISSN: 1432-2218
DOI
https://doi.org/10.1007/s00464-018-6217-x

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