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01-03-2008 | Original Paper

TDP-43 immunoreactivity in anoxic, ischemic and neoplastic lesions of the central nervous system

Authors: Edward B. Lee, Virginia M.-Y. Lee, John Q. Trojanowski, Manuela Neumann

Published in: Acta Neuropathologica | Issue 3/2008

Abstract

TDP-43 proteinopathies are a newly categorized group of neurodegenerative diseases characterized by progressive cognitive and motor impairments associated with the abnormal accumulation and mislocalization of the nuclear TAR–DNA-binding protein-43 (TDP-43) in neurons and glia. Little is known about the expression and distribution of TDP-43 in normal and pathologic states. To determine whether TDP-43 inclusions arise in response to metabolic insults such as anoxia or ischemia, a panel of anoxic, ischemic and neoplastic lesions was examined for TDP-43 expression by immunohistochemistry. These lesions did not exhibit TDP-43 inclusions like those seen in neurodegenerative frontotemporal dementia and motor neuron disease. However, TDP-43 was found in Rosenthal fibers and eosinophilic granular bodies associated with low-grade tumors and reactive brain tissue. Furthermore, cytoplasmic TDP-43 was seen in M-phase tumor cells, but not in mitotic spindles. These findings expand our knowledge of the distribution and localization of TDP-43, and indicate that the TDP-43 inclusions seen in frontotemporal dementias and motor neuron diseases are specific to a neurodegenerative process.

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Title: TDP-43 immunoreactivity in anoxic, ischemic and neoplastic lesions of the central nervous system
Authors: Edward B. Lee
Virginia M.-Y. Lee
John Q. Trojanowski
Manuela Neumann
Publication date: 01-03-2008
Publisher: Springer-Verlag
Published in: Acta Neuropathologica / Issue 3/2008
Print ISSN: 0001-6322
Electronic ISSN: 1432-0533
DOI: https://doi.org/10.1007/s00401-007-0331-5

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TDP-43 immunoreactivity in anoxic, ischemic and neoplastic lesions of the central nervous system

Abstract

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Abstract

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