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01-12-2013 | Research Article

TCTP overexpression is associated with the development and progression of glioma

Authors: Xia Miao, Yong-Bin Chen, Sheng-Long Xu, Tao Zhao, Jun-Ye Liu, Yu-Rong Li, Jin Wang, Jie Zhang, Guo-Zhen Guo

Published in: Tumor Biology | Issue 6/2013

Abstract

Upregulation of translationally controlled tumor protein (TCTP) has been reported in a variety of malignant tumors. However, the impact of TCTP in glioma remains unclear. The objective of this study was to investigate the expression and prognostic value of TCTP in glioma patients. Western blot analysis was used to characterize the expression patterns of TCTP in 45 glioma and 22 normal brain tissues. Immunohistochemistry on a tissue microarray containing 127 cases of glioma was performed to analyze the association between TCTP expression and clinicopathological features. Compared with normal brain tissues, TCTP expression was significantly higher in glioma tissues (p <0.001). In addition, high TCTP expression in glioma was significantly associated with advanced pathological grade (p = 0.018). Kaplan–Meier analysis showed that patients with glioma and higher TCTP expression tend to have shorter overall survival time (p <0.001). In multivariate analysis, TCTP expression was proved to be an independent prognostic factor for patients with glioma (p <0.001). In conclusion, this study confirmed the overexpression of TCTP and its association with tumor progression in glioma. It also provided the first evidence that TCTP expression in glioma was an independent prognostic factor of patients, which might be a potential diagnostic and therapeutic target of glioma.

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Title: TCTP overexpression is associated with the development and progression of glioma
Authors: Xia Miao
Yong-Bin Chen
Sheng-Long Xu
Tao Zhao
Jun-Ye Liu
Yu-Rong Li
Jin Wang
Jie Zhang
Guo-Zhen Guo
Publication date: 01-12-2013
Publisher: Springer Netherlands
Published in: Tumor Biology / Issue 6/2013
Print ISSN: 1010-4283
Electronic ISSN: 1423-0380
DOI: https://doi.org/10.1007/s13277-013-0906-9

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