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01-01-2007 | LETTER TO THE EDITORS

Tau missing from CSF

A case report

Authors: Antonella Alberici, MD, Mario Armani, MD, Anna Paterlini, PhD, Luisa Benussi, PhD, Francesca Nicosia, PhD, Roberta Ghidoni, PhD, Simona Signorini, PhD, Maria Cotelli, MSC, Giovanni B. Frisoni, MD, Cristina Geroldi, MD, PhD, Carlo P. Trevisan, MD, John H. Growdon, MD, Barbara Borroni, MD, Alessandro Padovani, MD, Paolo M. Rossini, Giuliano Binetti, MD

Published in: Journal of Neurology | Issue 1/2007

Excerpt

Sirs: Most of the neurodegenerative diseases known collectively as tauopathies, such as Frontotemporal Lobar Degeneration (FTLD), have excessive deposits of hyperphosphorylated tau in affected neurons and glia [6]. Paradoxically, the general label of tauopathy has been expanded to include cases in which tau was not identified in the brain and therefore were named as tau-less dementia [7, 12, 13]. …

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Engelborghs S, Maertens K, Vloeberghs E, Aerts T, Somers N, Marien P, De Deyn PP (2006) Neuropsychological and behavioural correlates of CSF biomarkers in dementia. Neurochem Int 48:286–295PubMedCrossRef

Grossman M, Farmer J, Leight S, Work M, Moore P, Van Deerlin V, Praticò D, Clark CM, Coslett HB, Chatterjee A, Gee J, Trojanowski JQ, Lee VM (2005) Cerebrospinal fluid profile in Frontotemporal Dementia and Alzheimer’s Disease. Ann Neurol 57:721–729PubMedCrossRef

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Pijnenburg YA, Schoonenboom SN, Barkhof F, Knol DL, Mulder C, Van Kamp GJ, Van Swieten JC, Scheltens P (2006) CSF biomarkers in frontotemporal lobar degeneration: relations with clinical characteristics, apolipoprotein E genotype, and neuroimaging. J Neurol Neurosurg Psychiatry 77:246–248PubMedCrossRef

Riemenschneider M, Wagenpfeil S, Diehl J, Lautenschlager N, Theml T, Heldmann B, Drzezga A, Jahn T, Forstl H, Kurz A (2002) Tau and Abeta42 protein in CSF of patients with frontotemporal degeneration. Neurology 58:1585–1586

10.

Sjogren M, Vanderstichele H, Agren H, Zachrisson O, Edsbagge M, Wikkelso C, Skoog I, Wallin A, Wahlund LO, Marcusson J, Nagga K, Andreasen N, Davidsson P, Vanmechelen E, Blennow K (2001) Tau and Aβ42 in Cerebrospinal fluid from healthy adults 21-93 years of age: establishment of reference values. Clin Chem 47:1776–1781PubMed

11.

Verbeek MM, Pijnenburg YA, Schoonenboom NS, Kremer BP, Scheltens P (2005) Cerebrospinal Fluid Tau Levels in Frontotemporal Dementia. Ann Neurol 58:656–657PubMedCrossRef

12.

Zhukareva V, Vogelsberg-Ragaglia V, Van Deerlin VM, Bruce J, Shuck T, Grossman M, Clark CM, Arnold SE, Masliah E, Galasko D, Trojanowski JQ, Lee VM (2001) Loss of brain tau defines novel sporadic and familial tauopathies with frontotemporal dementia. Ann Neurol 49:165–175PubMedCrossRef

13.

Zhukareva V, Sundarraj S, Mann D, Sjogren M, Blennow K, Clark CM, McKeel DW, Goate A, Lippa CF, Vonsattel JP, Growdon JH, Trojanowski JQ, Lee VM (2003) Selective reduction of soluble tau proteins in sporadic and familial frontotemporal dementias: an international follow-up study. Acta Neuropathol (Berl) 105:469–476

Title: Tau missing from CSF
A case report
Authors: Antonella Alberici, MD
Mario Armani, MD
Anna Paterlini, PhD
Luisa Benussi, PhD
Francesca Nicosia, PhD
Roberta Ghidoni, PhD
Simona Signorini, PhD
Maria Cotelli, MSC
Giovanni B. Frisoni, MD
Cristina Geroldi, MD, PhD
Carlo P. Trevisan, MD
John H. Growdon, MD
Barbara Borroni, MD
Alessandro Padovani, MD
Paolo M. Rossini
Giuliano Binetti, MD
Publication date: 01-01-2007
Publisher: Steinkopff-Verlag
Published in: Journal of Neurology / Issue 1/2007
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-006-0282-0

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Tau missing from CSF

A case report

Excerpt

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