Top

Graefe's Archive for Clinical and Experimental Ophthalmology

Published in:

01-10-2018 | Editorial

Targeting myeloid cells in ischemic retinal vascular diseases

Authors: Christina Nürnberg, Norbert Kociok, Antonia M. Joussen

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 10/2018

Excerpt

The discovery and clinical application of anti-VEGF-directed antibodies has revolutionized the treatment regime and clinical outcome in patients with wet age-related macular degeneration, diabetic retinopathy, retinal vein occlusion, and retinopathy of prematurity [1‐3]. Still, the search for more specific cellular and molecular targets is ongoing. …

Lai TYY, Staurenghi G, Lanzetta P, Holz FG, Melissa Liew SH, Desset-Brethes S, Staines H, Hykin PG, MINERVA study group (2017) Efficacy and safety of ranibizumab for the treatment of choroidal neovascularization due to uncommon cause: twelve-month results of the MINERVA study. Retina. https://doi.org/10.1097/IAE.0000000000001744

Mitchell P, Bandello F, Schmidt-Erfurth U, Lang GE, Massin P, Schlingemann RO, Sutter F, Simader C, Burian G, Gerstner O, Weichselberger A, RESTORE study group (2011) The RESTORE study: ranibizumab monotherapy or combined with laser versus laser monotherapy for diabetic macular edema. Ophthalmology 118:615–625CrossRefPubMed

Mintz-Hittner HA, Kennedy KA, Chuang AZ, for the BEAT-ROP Cooperative Group (2011) Efficacy of intravitreal bevacizumab for stage 3+ retinopathy of prematurity. N Engl J Med 364:603–615CrossRefPubMedPubMedCentral

Joussen AM, Murata T, Tsujikawa A, Kirchhof B, Bursell S-E, Adamis AP (2001) Leukocyte-mediated endothelial cell injury and death in the diabetic retina. Am J Pathol 158:147–152CrossRefPubMedPubMedCentral

Joussen AM, Poulaki V, Le ML, Koizumi K, Esser C, Janicki H, Schraermeyer U, Kociok N, Fauser S, Kirchhof B, Kern TS, Adamis AP (2004) A central role for inflammation in the pathogenesis of diabetic retinopathy. FASEB J 18:1450–1452CrossRefPubMed

Sakurai E, Anand A, Ambati BK, van Rooijen N, Ambati J (2003) Macrophage depletion inhibits experimental choroidal neovascularization. IOVS 44:3578–3585

Davies MH, Eubanks JP, Powers MR (2006) Microglia and macrophages are increased in response to ischemia-induced retinopathy in the mouse retina. Mol Vis 12:467–477PubMed

Checchin D, Sennlaub F, Levavasseur E, Leduc M, Chemtob S (2006) Potential role of microglia in retinal blood vessel formation. IOVS 47:3595–3602

Karlstetter M, Ebert S, Langmann T (2010) Microglia in the healthy and degenerating retina: insights from novel mouse models. Immunobiology 215:685–691CrossRefPubMed

10.

Naug HL, Browning J, Gole GA, Gobé G (2000) Vitreal macrophages express vascular endothelial growth factor in oxygen-induced retinopathy. Clin Exp Ophthalmol 28:48–52CrossRefPubMed

11.

Ishida S, Usui T, Yamashiro K, Kaji Y, Amano S, Ogura Y, Hida T, Oguchi Y, Ambati J, Miller JW, Gragoudas ES, Ng YS, D'Amore PA, Shima DT, Adamis AP (2003) VEGF164-mediated inflammation is required for pathological, but not physiological, ischemia-induced retinal neovascularization. J Exp Med 198:483–489CrossRefPubMedPubMedCentral

12.

Kubota Y, Takubo K, Shimizu T, Ohno H, Kishi K, Shibuya M, Saya H, Suda T (2009) M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis. J Exp Med 206:1089–1102CrossRefPubMedPubMedCentral

13.

Liyanage SE, Fantin A, Villacampa P, Lange CA, Denti L, Cristante E, Smith AJ, Ali RR, Luhmann UF, Bainbridge JW, Ruhrberg C (2016) Myeloid-derived vascular endothelial growth factor and hypoxia-inducible factor are dispensable for ocular neovascularization. Arterioscler Thromb Vasc Biol 36:19–24CrossRefPubMed

14.

Nürnberg C, Kociok N, Brockmann C, Lischke T, Crespo-Garcia S, Reichhart N, Wolf S, Baumgrass R, Eming SA, Beer-Hammer S, Joussen AM (2018) Myeloid cells contribute indirectly to VEGF expression upon hypoxia via activation of Müller cells. Exp Eye Res 166:56–69CrossRefPubMed

15.

Fantin A, Vieira JM, Gestri G, Denti L, Schwarz Q, Prykhozhij S, Peri F, Wilson SW, Ruhrberg C (2010) Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell induction. Blood. https://doi.org/10.1182/blood-2009-12-257832

16.

Chan-Ling T, Pe'er J, Itin A, Gnessin H, Keshet E (1996) Roles of vascular endothelial growth factor and astrocyte degeneration in the genesis of retinopathy of prematurity. IOVS 37:290–299

17.

Miller JW (1997) Vascular endothelial growth factor and ocular neovascularization. Am J Pathol 151:13–23PubMedPubMedCentral

18.

Pierce EA, Avery RL, Foley ED, Aiello LP, Smith LEH (1995) Vascular endothelial growth factor/vascular permeability factor expression in a mouse model of retinal neovascularization. PNAS 92:905–909CrossRefPubMed

19.

Wang J, Xu X, Elliott MH, Zhu M, Yun-Zheng Le Y-Z (2010) Müller cell-derived VEGF is essential for diabetes-induced retinal inflammation and vascular leakage. Diabetes 59:2297–2305CrossRefPubMedPubMedCentral

Title: Targeting myeloid cells in ischemic retinal vascular diseases
Authors: Christina Nürnberg
Norbert Kociok
Antonia M. Joussen
Publication date: 01-10-2018
Publisher: Springer Berlin Heidelberg
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 10/2018
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-018-4107-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Targeting myeloid cells in ischemic retinal vascular diseases

Excerpt

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Excerpt

Please log in to get access to this content

Other articles of this Issue 10/2018

Different glaucoma types and glaucoma surgeries among different age groups

Comparative analysis of visual outcomes, reading skills, contrast sensitivity, and patient satisfaction with two models of trifocal diffractive intraocular lenses and an extended range of vision intraocular lens

Calf melanin immunomodulates RPE cell attachment to extracellular matrix protein

Characterization of the retina-induced relaxation in mice

The effect of methotrexate and sulfasalazine on the course of HLA-B27-positive anterior uveitis: results from a retrospective cohort study

Effects of ostium granulomas and intralesional steroid injections on the surgical outcome in endoscopic dacryocystorhinostomy