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01-10-2010 | Viewpoint

Targeting breast cancer stem cells: fishing season open!

Authors: Christophe Ginestier, Emmanuelle Charafe-Jauffret, Daniel Birnbaum

Published in: Breast Cancer Research | Issue 5/2010

Abstract

Studies describing the tumor as a hierarchically organized cell population have changed the classical oncogenesis view and propose new therapeutic strategies. Cancer stem cells (CSCs) are thought to sustain tumor initiation/maintenance, therapy resistance, and systemic metastases. Targeting this tumor cell population is crucial to achieve a true cancer cure. A large research effort is now aiming to develop drugs targeting CSCs, based either on a priori understanding of key pathways regulating CSC biology or on high-throughput screening to identify novel targets and compounds.

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Title: Targeting breast cancer stem cells: fishing season open!
Authors: Christophe Ginestier
Emmanuelle Charafe-Jauffret
Daniel Birnbaum
Publication date: 01-10-2010
Publisher: BioMed Central
Published in: Breast Cancer Research / Issue 5/2010
Electronic ISSN: 1465-542X
DOI: https://doi.org/10.1186/bcr2636

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