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01-05-2012 | Laboratory Investigation

Targeting Aurora Kinase A enhances radiation sensitivity of atypical teratoid rhabdoid tumor cells

Authors: Sujatha Venkataraman, Irina Alimova, Tiffany Tello, Peter S. Harris, Jeffrey A. Knipstein, Andrew M. Donson, Nicholas K. Foreman, Arthur K. Liu, Rajeev Vibhakar

Published in: Journal of Neuro-Oncology | Issue 3/2012

Abstract

Atypical teratoid/rhabdoid tumors (ATRT) are rare, highly malignant, embryonal CNS tumors with a poor prognosis. Therapy relies on highly toxic chemotherapy and radiotherapy. To improve outcomes and decrease morbidity, more targeted therapy is required. Gene expression analysis revealed elevated expression of multiple kinases in ATRT tissues. Aurora Kinase A was one of the candidate kinases. The objective of this study was to evaluate the impact of Aurora Kinase A inhibition in ATRT cell lines. Our analysis revealed that inhibition of Aurora Kinase A induces cell death in ATRT cells and the small molecule inhibitor MLN 8237 sensitizes these cells to radiation. Furthermore, inhibition of Aurora Kinase A resulted in decreased activity of pro-proliferative signaling pathways. These data indicate that inhibition of Aurora Kinase A is a promising small molecule target for ATRT therapy.

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Title: Targeting Aurora Kinase A enhances radiation sensitivity of atypical teratoid rhabdoid tumor cells
Authors: Sujatha Venkataraman
Irina Alimova
Tiffany Tello
Peter S. Harris
Jeffrey A. Knipstein
Andrew M. Donson
Nicholas K. Foreman
Arthur K. Liu
Rajeev Vibhakar
Publication date: 01-05-2012
Publisher: Springer US
Published in: Journal of Neuro-Oncology / Issue 3/2012
Print ISSN: 0167-594X
Electronic ISSN: 1573-7373
DOI: https://doi.org/10.1007/s11060-011-0795-y

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Targeting Aurora Kinase A enhances radiation sensitivity of atypical teratoid rhabdoid tumor cells

Abstract

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