Published in:
01-01-2012
Targeting Angiogenesis in Gastroesophageal Cancer: Industry-Sponsored Trials are not the Answer
Author:
Sarah K. Thompson
Published in:
World Journal of Surgery
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Issue 1/2012
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Excerpt
Angiogenesis is a dynamic process essential for tumor growth. Maeda et al. first reported its association with poor prognosis in gastric cancer in 1996 and, since then, there have been numerous similar studies examining various factors that mediate angiogenesis such as vascular endothelial growth factor (VEGF) and platelet-derived growth factor [
1]. It is therefore surprising that a decade and a half later there is still no clear consensus on the role of antiangiogenic agents in the treatment of gastroesophageal cancer and, more importantly, recognition of the patient subset who are most likely to benefit from these expensive agents. …