Skip to main content
Top
Published in: Neurocritical Care 2/2017

Open Access 01-04-2017 | Practical Pearl

Takotsubo Cardiomyopathy in Traumatic Brain Injury

Authors: Chun Fai Cheah, Mario Kofler, Alois Josef Schiefecker, Ronny Beer, Gert Klug, Bettina Pfausler, Raimund Helbok

Published in: Neurocritical Care | Issue 2/2017

Login to get access

Abstract

Background

Takotsubo cardiomyopathy (TC) is a well-known complication after aneurysmal subarachnoid hemorrhage and has been rarely described in patients with traumatic brain injury (TBI).

Methods

Case report and review of literature.

Results

Here, we report a 73-year-old woman with mild traumatic brain injury (TBI) presenting in cardiogenic shock. Takotsubo cardiomyopathy (TC) was diagnosed by repeated echocardiography. Cardiovascular support by inotropic agents led to hemodynamic stabilization after initiation of levosimendan. Cardiac function fully recovered within 21 days. We performed an in-depth literature review and identified 16 reported patients with TBI and TC. Clinical course and characteristics are discussed in the context of our patient.

Conclusion

Takotsubo cardiomyopathy is under-recognized after TBI and may negatively impact outcome if left untreated.
Appendix
Available only for authorised users
Literature
1.
go back to reference Lee VH, Connolly HM, Fulgham JR, Manno EM, Brown RD Jr, Wijdicks EFM. Tako-tsubo cardiomyopathy in aneurysmal subarachnoid hemorrhage: an under appreciated ventricular dysfunction. J Neurosurg. 2006;105:264–70.CrossRefPubMed Lee VH, Connolly HM, Fulgham JR, Manno EM, Brown RD Jr, Wijdicks EFM. Tako-tsubo cardiomyopathy in aneurysmal subarachnoid hemorrhage: an under appreciated ventricular dysfunction. J Neurosurg. 2006;105:264–70.CrossRefPubMed
2.
go back to reference Kilbourn KJ, Levy S, Staff I, Kureshi I, McCullough L. Clinical characteristics and outcomes of neurogenic stress cardiomyopathy in aneurysmal subarachnoid hemorrhage. Clin Neurol Neurosurg. 2013;115:909–14.CrossRefPubMed Kilbourn KJ, Levy S, Staff I, Kureshi I, McCullough L. Clinical characteristics and outcomes of neurogenic stress cardiomyopathy in aneurysmal subarachnoid hemorrhage. Clin Neurol Neurosurg. 2013;115:909–14.CrossRefPubMed
3.
go back to reference Banki N, Kopelnik A, Tung P, et al. Prospective analysis of prevalence, distribution, and rate of recovery of left ventricular systolic dysfunction in patients with subarachnoid hemorrhage. J Neurosurg. 2006;105:15–20.CrossRefPubMed Banki N, Kopelnik A, Tung P, et al. Prospective analysis of prevalence, distribution, and rate of recovery of left ventricular systolic dysfunction in patients with subarachnoid hemorrhage. J Neurosurg. 2006;105:15–20.CrossRefPubMed
4.
go back to reference Finsterer J, Wahbi K. CNS disease triggering Takotsubo stress cardiomyopathy: review. Int J Cardiol. 2014;177:322–9.CrossRefPubMed Finsterer J, Wahbi K. CNS disease triggering Takotsubo stress cardiomyopathy: review. Int J Cardiol. 2014;177:322–9.CrossRefPubMed
5.
go back to reference Ruiz-Bailén M, Aguayo-de Hoyos E, López Martinez A, et al. Reversible myocardial dysfunction, a possible complication in critically ill patients without heart disease. J Crit Care. 2003;18:245–52.CrossRefPubMed Ruiz-Bailén M, Aguayo-de Hoyos E, López Martinez A, et al. Reversible myocardial dysfunction, a possible complication in critically ill patients without heart disease. J Crit Care. 2003;18:245–52.CrossRefPubMed
6.
go back to reference Park JH, Kang SJ, Song JK, Kim HK, Lim CM, Kang DH, Koh Y. Left ventricular apical ballooning due to severe physical stress in patients admitted to the medical ICU. Chest. 2005;128:296–302.CrossRefPubMed Park JH, Kang SJ, Song JK, Kim HK, Lim CM, Kang DH, Koh Y. Left ventricular apical ballooning due to severe physical stress in patients admitted to the medical ICU. Chest. 2005;128:296–302.CrossRefPubMed
7.
go back to reference Palac RT, Sumner G, Laird R, O’Rourke DJ. Reversible myocardial dysfunction after traumatic brain injury: mechanisms and implications for heart transplantation. Prog Transplant. 2003;13:42–6.CrossRefPubMed Palac RT, Sumner G, Laird R, O’Rourke DJ. Reversible myocardial dysfunction after traumatic brain injury: mechanisms and implications for heart transplantation. Prog Transplant. 2003;13:42–6.CrossRefPubMed
8.
go back to reference Krishnamoorthy V, Sharma D, Prathep S, Vavilala MS. Myocardial dysfunction in acute traumatic brain injury relieved by surgical decompression. Case Rep Anaesthesiol. 2013;2013:1–4.CrossRef Krishnamoorthy V, Sharma D, Prathep S, Vavilala MS. Myocardial dysfunction in acute traumatic brain injury relieved by surgical decompression. Case Rep Anaesthesiol. 2013;2013:1–4.CrossRef
9.
go back to reference Divekar A, Shah S, Joshi C. Neurogenic stunned myocardium and transient severe tricuspid regurgitation in a child following non-accidental head trauma. Pediatr Cardiol. 2006;27(3):376–7.CrossRefPubMed Divekar A, Shah S, Joshi C. Neurogenic stunned myocardium and transient severe tricuspid regurgitation in a child following non-accidental head trauma. Pediatr Cardiol. 2006;27(3):376–7.CrossRefPubMed
10.
go back to reference Deleu D, Kettern MA, Hanssens Y, Kumar S, Salim K, Miyares F. Neurogenic stunned myocardium following hemorrhagic cerebral contusion. Saudi Med J. 2007;28(2):283–5.PubMed Deleu D, Kettern MA, Hanssens Y, Kumar S, Salim K, Miyares F. Neurogenic stunned myocardium following hemorrhagic cerebral contusion. Saudi Med J. 2007;28(2):283–5.PubMed
11.
go back to reference Wippermann J, Bennink G, Wittwer T, Madershahian N, Ortmann C, Wahlers T. Reversal of myocardial dysfunction due to brain injury. Asian Cardiovasc Thorac Ann. 2008;16(3):30–1.CrossRef Wippermann J, Bennink G, Wittwer T, Madershahian N, Ortmann C, Wahlers T. Reversal of myocardial dysfunction due to brain injury. Asian Cardiovasc Thorac Ann. 2008;16(3):30–1.CrossRef
12.
go back to reference Maréchaux S, Goldstein P, Girardie P, Ennezat PV. Contractile pattern of inverted takotsubo cardiomyopathy: illustration by two-dimensional strain. Eur J Echocardiogr. 2009;10(2):332–3.CrossRefPubMed Maréchaux S, Goldstein P, Girardie P, Ennezat PV. Contractile pattern of inverted takotsubo cardiomyopathy: illustration by two-dimensional strain. Eur J Echocardiogr. 2009;10(2):332–3.CrossRefPubMed
13.
go back to reference Vergez M, Pirracchio R, Mateo J, Payen D, Cholley B. Tako tsubo cardiomyopathy in a patient with multiple trauma. Resuscitation. 2009;80(9):1074–7.CrossRefPubMed Vergez M, Pirracchio R, Mateo J, Payen D, Cholley B. Tako tsubo cardiomyopathy in a patient with multiple trauma. Resuscitation. 2009;80(9):1074–7.CrossRefPubMed
14.
go back to reference Riera M, Llompart-Pou JA, Carillo A, Blanco C. Head injury and inverted takotsubo cardiomyopathy. J Trauma. 2010;68:13–5.CrossRef Riera M, Llompart-Pou JA, Carillo A, Blanco C. Head injury and inverted takotsubo cardiomyopathy. J Trauma. 2010;68:13–5.CrossRef
15.
go back to reference Samol A, Grude M, Stypmann J, et al. Acute global cardiac decompensation due to inverted takotsubo cardiomyopathy after skull-brain trauma- a case report. Injury Extra. 2011;42(5):54–7.CrossRef Samol A, Grude M, Stypmann J, et al. Acute global cardiac decompensation due to inverted takotsubo cardiomyopathy after skull-brain trauma- a case report. Injury Extra. 2011;42(5):54–7.CrossRef
16.
go back to reference Santoro F, Ieva R, Ferraretti A, et al. Safety and feasibility of levosimendan administration in takotsubo cardiomyopathy: a case series. Cardiovasc Ther. 2013;31(6):133–7.CrossRef Santoro F, Ieva R, Ferraretti A, et al. Safety and feasibility of levosimendan administration in takotsubo cardiomyopathy: a case series. Cardiovasc Ther. 2013;31(6):133–7.CrossRef
17.
go back to reference Krpata DM, Barksdle EM Jr. Trauma induced left ventricular apical ballooning syndrome in a 15 year-old: a rare case of tako-tsubo cardiomyopathy. J Pediatr Surg. 2013;48:876–9.CrossRefPubMed Krpata DM, Barksdle EM Jr. Trauma induced left ventricular apical ballooning syndrome in a 15 year-old: a rare case of tako-tsubo cardiomyopathy. J Pediatr Surg. 2013;48:876–9.CrossRefPubMed
18.
go back to reference Bonacchi M, Vannini A, Harmelin G, et al. Inverted-takotsubo cardiomyopathy: severe refractory heart failure in poly-trauma patients saved by emergency extracorporeal life support. Interact Cardiovasc Thorac Surg. 2015;20(3):365–71.CrossRefPubMed Bonacchi M, Vannini A, Harmelin G, et al. Inverted-takotsubo cardiomyopathy: severe refractory heart failure in poly-trauma patients saved by emergency extracorporeal life support. Interact Cardiovasc Thorac Surg. 2015;20(3):365–71.CrossRefPubMed
19.
go back to reference Hong J, Glater-Welt LB, Siegel LB. Takotsubo cardiomyopathy in a 23 months-old following traumatic brain injury. Ann Pediatr Child Health. 2014;2(4):1029. Hong J, Glater-Welt LB, Siegel LB. Takotsubo cardiomyopathy in a 23 months-old following traumatic brain injury. Ann Pediatr Child Health. 2014;2(4):1029.
20.
go back to reference Bahloul M, Chaari AN, Kallel H, et al. Neurogenic pulmonary edema due to traumatic brain injury: evidence of cardiac dysfunction. Am J Crit Care. 2006;15(5):462–70.PubMed Bahloul M, Chaari AN, Kallel H, et al. Neurogenic pulmonary edema due to traumatic brain injury: evidence of cardiac dysfunction. Am J Crit Care. 2006;15(5):462–70.PubMed
21.
go back to reference Prathep S, Sharma D, Hallman M, et al. Preliminary report on cardiac dysfunction after isolated traumatic brain injury. Crit Care Med. 2014;42:142–7.CrossRefPubMed Prathep S, Sharma D, Hallman M, et al. Preliminary report on cardiac dysfunction after isolated traumatic brain injury. Crit Care Med. 2014;42:142–7.CrossRefPubMed
22.
go back to reference Hasanin A, Kamal A, Amin S, et al. Incidence and outcome of cardiac injury in patients with severe head trauma. Scand J Trauma, Resus Emerg Med. 2016;24:58.CrossRef Hasanin A, Kamal A, Amin S, et al. Incidence and outcome of cardiac injury in patients with severe head trauma. Scand J Trauma, Resus Emerg Med. 2016;24:58.CrossRef
23.
go back to reference Lyon AR, Bossone E, Schneider B, et al. Current state of knowledge on Takotsubo syndrome: a position statement from the taskforce on Takotsubo syndrome of the heart failure association of the European society of cardiology. Eur J Heart Fail. 2016;18(1):8–27.CrossRefPubMed Lyon AR, Bossone E, Schneider B, et al. Current state of knowledge on Takotsubo syndrome: a position statement from the taskforce on Takotsubo syndrome of the heart failure association of the European society of cardiology. Eur J Heart Fail. 2016;18(1):8–27.CrossRefPubMed
24.
go back to reference Templin C, Ghadri JR, Diekmann J, et al. Clinical features and outcomes of Takotsubo (stress) cardiomyopathy. N Engl J Med. 2015;373(10):929–38.CrossRefPubMed Templin C, Ghadri JR, Diekmann J, et al. Clinical features and outcomes of Takotsubo (stress) cardiomyopathy. N Engl J Med. 2015;373(10):929–38.CrossRefPubMed
25.
go back to reference Bybee KA, Kara T, Prasad A, et al. Systematic review: transient left ventricular apical ballooning: a syndrome that mimics ST-segment elevation myocardial infarction. Ann Intern Med. 2004;141(11):858–65.CrossRefPubMed Bybee KA, Kara T, Prasad A, et al. Systematic review: transient left ventricular apical ballooning: a syndrome that mimics ST-segment elevation myocardial infarction. Ann Intern Med. 2004;141(11):858–65.CrossRefPubMed
26.
go back to reference Wittstein IS, Thiemann DR, Lima JA, et al. Neurohumoral features of myocardial stunning due to sudden emotional stress. N Engl J Med. 2005;352(6):539–48.CrossRefPubMed Wittstein IS, Thiemann DR, Lima JA, et al. Neurohumoral features of myocardial stunning due to sudden emotional stress. N Engl J Med. 2005;352(6):539–48.CrossRefPubMed
27.
go back to reference Lyon AR, Rees PS, Prasad S, Poole-Wilson PA, Harding SE. Stress (Takotsubo) cardiomyopathy—a novel pathophysiological hypothesis to explain catecholamine-induced acute myocardial stunning. Nat Clin Prac Cardiovasc Med. 2008;5:22–9.CrossRef Lyon AR, Rees PS, Prasad S, Poole-Wilson PA, Harding SE. Stress (Takotsubo) cardiomyopathy—a novel pathophysiological hypothesis to explain catecholamine-induced acute myocardial stunning. Nat Clin Prac Cardiovasc Med. 2008;5:22–9.CrossRef
28.
go back to reference Paur H, Wright PT, Sikkel MB, et al. High levels of circulating epinephrine trigger apical cardiodepression in a ß2-adrenergic receptor/Gi–dependent manner: a new model of Takotsubo cardiomyopathy. Circulation. 2012;126(6):697–706.CrossRefPubMedPubMedCentral Paur H, Wright PT, Sikkel MB, et al. High levels of circulating epinephrine trigger apical cardiodepression in a ß2-adrenergic receptor/Gi–dependent manner: a new model of Takotsubo cardiomyopathy. Circulation. 2012;126(6):697–706.CrossRefPubMedPubMedCentral
29.
go back to reference Brain Trauma Foundation, American Association of Neurological Surgeons (AANS), Congress of Neurological Surgeons (CNS), AANS/CNS Joint Section on Neurotrauma and Critical Care. Guidelines for the management of severe traumatic brain injury, 3rd edition. J Neurotrauma. 2007;24(suppl 1):S1–S106. Brain Trauma Foundation, American Association of Neurological Surgeons (AANS), Congress of Neurological Surgeons (CNS), AANS/CNS Joint Section on Neurotrauma and Critical Care. Guidelines for the management of severe traumatic brain injury, 3rd edition. J Neurotrauma. 2007;24(suppl 1):S1–S106.
30.
go back to reference Taccone FS, Brasseur A, Vincent JL, De Backer D. Levosimendan for the treatment of subarachnoid haemorrhage-related cardiogenic shock. Intensive Care Med. 2013;39(8):1497–8.CrossRefPubMed Taccone FS, Brasseur A, Vincent JL, De Backer D. Levosimendan for the treatment of subarachnoid haemorrhage-related cardiogenic shock. Intensive Care Med. 2013;39(8):1497–8.CrossRefPubMed
31.
go back to reference Parissis JT, Rafouli-Stergiou P, Paraskevaidis I, Mebazaa A. Levosimendan: from basic science to clinical practice. Heart Fail Rev. 2009;14(4):265–75.CrossRefPubMed Parissis JT, Rafouli-Stergiou P, Paraskevaidis I, Mebazaa A. Levosimendan: from basic science to clinical practice. Heart Fail Rev. 2009;14(4):265–75.CrossRefPubMed
Metadata
Title
Takotsubo Cardiomyopathy in Traumatic Brain Injury
Authors
Chun Fai Cheah
Mario Kofler
Alois Josef Schiefecker
Ronny Beer
Gert Klug
Bettina Pfausler
Raimund Helbok
Publication date
01-04-2017
Publisher
Springer US
Published in
Neurocritical Care / Issue 2/2017
Print ISSN: 1541-6933
Electronic ISSN: 1556-0961
DOI
https://doi.org/10.1007/s12028-016-0334-y

Other articles of this Issue 2/2017

Neurocritical Care 2/2017 Go to the issue