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01-01-2010 | Experimental

T2 and T2* measurements of fetal brain oxygenation during hypoxia with MRI at 3T: correlation with fetal arterial blood oxygen saturation

Authors: Ulrike Wedegärtner, Hendrik Kooijman, Thomas Andreas, Nicola Beindorff, Kurt Hecher, Gerhard Adam

Published in: European Radiology | Issue 1/2010

Abstract

The purpose of this prospective study was to determine the oxygen saturation of blood in the fetal brain based on T2 and T2* measurements in a fetal sheep model. Five sheep fetuses were investigated during normoxia and hypoxia by 3T MRI. Multi-echo gradient-echo and turbo-spin-echo sequences were performed on the fetal brain. MR-determined oxygen saturation (MR-sO₂) of blood in the fetal brain was calculated based on T2 and T2* values. Fetal arterial blood oxygen saturation (blood-sO₂) was measured during the two experimental phases. The slope of MR-sO₂ as a function of blood-sO₂ was estimated and tested for compatibility using the one-sample t-test. During normoxia, mean values for carotid blood oxygen saturation were 67%, 83 ms for T2*, 202 ms for T2 and 96% for MR-sO₂. During hypoxia, arterial blood oxygen saturation, T2* and calculated MR-sO₂ decreased to 22%, 64 ms, and 68% respectively. The one-sample t-test revealed the slope to be significantly different from 0 (T = 5.023, df = 4, P = 0.007). It is feasible to perform quantitative T2 and T2* measurements in the fetal brain. MR-sO₂ and fetal arterial blood oxygen saturation correlated significantly. However, based on these data a reliable quantification of fetal brain tissue oxygenation is not possible.

Tuunanen PI, Kauppinen RA (2006) Effects of oxygen saturation on BOLD and arterial spin labelling perfusion fMRI signals studied in a motor activation task. Neuroimage 30:102–109CrossRefPubMed

Ogawa S, Lee TM, Kay AR, Tank DW (1990) Brain magnetic resonance imaging with contrast dependent on blood oxygenation. Proc Natl Acad Sci 87:9868–9872CrossRefPubMed

Wedegärtner U, Tchirikov M, Koch M, Adam G, Schröder H (2002) Functional magnetic resonance imaging (fMRI) for fetal oxygenation during maternal hypoxia: initial results. Fortschr Röntgenstr 174:700–703CrossRef

Wedegärtner U, Tchirikov M, Schäfer S, Priest A, Walther M, Adam G, Schröder H (2005) Functional MRI (BOLD) at 3 Tesla in the brain of fetal sheep: methodological aspects and the relation to maternal blood oxygenation during hypoxia. Radiology 237:919–926CrossRefPubMed

Ogawa S, Lee TM, Barrere B (1993) The sensitivity of magnetic resonance image signals of a rat brain to changes in the cerebral venous blood oxygenation. Magn Reson Med 29:205–210CrossRefPubMed

Yablonskiy DA, Haacke EM (1994) Theory of NMR signal behavior in magnetically inhomogenous tissues: the static dephasing regime. MRM 32:749–763

van Cappellen AM, Heerschap A, Nijhuis JG, Oeseburg B, Jongsma HW (1999) Hypoxia, the subsequent systemic metabolic acidosis, and their relationship with cerebral metabolite concentrations: an in vivo study in fetal lambs with proton magnetic resonance spectroscopy. Am J Obstet Gynecol 181:1537–1545CrossRefPubMed

He X, Yablonskiy DA (2007) Quantitative BOLD: mapping of human cerebral deoxygenated blood volume and oxygen extraction fraction: default state. Magn Reson Med 57:115–126CrossRefPubMed

He X, Zhu M, Yablonskiy DA (2008) Validation of oxygen extraction fraction measurement by qBOLD technique. Magn Reson Med 60:882–888CrossRefPubMed

10.

Dahnke H, Schaeffter T (2005) Limits of detection of SPIO at 3.0 T using T2 relaxometry. Magn Reson Med 53:1202–1206CrossRefPubMed

11.

Julien-Dolbec C, Tropres I, Montigon O, Reutenauer H, Ziegler A, Decorps M, Payen JF (2002) Regional response of cerebral blood volume to graded hypoxic hypoxia in rat brain. Br J Anaesth 89:287–293CrossRefPubMed

12.

Kennan RP, Scanley BE, Gore J (1997) Physiological basis of BOLD MR signal changes due to hypoxia/hyperoxia: separation of blood volume and magnetic susceptibility effects. Magn Reson Med 37:353–356CrossRef

13.

Lin W, Celik A, Paczynski RP, Hsu C, Powers W (1999) Quantitative magnetic resonance imaging in experimental hypercapnia: improvement in the relation between changes in brain R2* and the oxygen saturation of venous blood after correction of changes in cerebral blood volume. J Cereb Blood Flow Metab 19:853–862CrossRefPubMed

14.

Posse S, Kemna LJ, Elghahwagi B, Wiese S, Kiselev VG (2001) Effect of graded hypo- and hypercapnia on fMRI contrast in visual cortex: quantification of T2* changes by multiecho EPI. Magn Reson Med 46:264–271CrossRefPubMed

15.

Spees WM, Yablonskiy DA, Oswood MC, Ackerman JJ (2001) Water proton MR properties of human blood at 1.5 Tesla: magnetic susceptibility, T(1), T(2), T*(2), and non-Lorentzian signal behavior. Magn Reson Med 45:533–542CrossRefPubMed

16.

Leenders KL, Perani D, Lammertsma AA, Heather JD, Buckingham P, Healy MJ, Gibbs JM, Wise RJ, Hatazawa J, Herold S et al (1990) Cerebral blood flow, blood volume and oxygen utilization. Normal values and effect of age. Brain 113:27–47CrossRefPubMed

17.

Ito H, Kanno I, Iida H, Hatazawa J, Shimosegawa E, Tamura H, Okudera T (2001) Arterial fraction of cerebral blood volume in humans measured by positron emission tomography. Ann Nucl Med 15:111–116CrossRefPubMed

18.

Jones MD, Sheldon RE, Peeters LL, Meschia G, Battaglia FC, Makowski EL (1977) Fetal cerebral oxygen consumption at different levels of oxygenation. J Appl Physiol 43:1080–1084PubMed

19.

Gelman N, Gorell JM, Barker PB, Savage RM, Spickler EM, Windham JP, Knight RA (1999) MR imaging of human brain at 3.0 T: preliminary report on transverse relaxation rates and relation to estimated iron content. Radiology 210:759–767PubMed

20.

Ogawa S, Menon RS, Tank DW, Kim SG, Markle H, Ellermann JM, Ugurbil K (1993) Functional brain mapping by blood oxygenation level dependent contrast magnetic resonance imaging. Biophys J 64:803–812CrossRefPubMed

21.

Prielmeier F, Nagatomo Y, Frahm J (1994) Cerebral blood oxygenation in rat brain during hypoxic hypoxia: quantitative MRI of effective transverse elaxation rates. Magn Reson Med 31:678–681CrossRefPubMed

22.

Thulborn KR, Waterton JC, Matthews PM, Radda GK (1982) Oxygenation dependence of the transverse relaxation time of water protons in whole blood at high field. Biochim Biophys Acta 714:265–270PubMed

23.

Punwani S, Ordidge RJ, Cooper CE, Amess P, Clemence M (1998) MRI measurements of cerebral deoxyhemoglobin concentration [dHb] - correlation with near infrared spectroscopy (NIRS). NMR Biomed 11:281–289CrossRefPubMed

24.

Hoppel BE, Weisskoff RM, Thulborn KR, Moore JB, Kwong KK, Rosen BR (1993) Measurement of regional blood oxygenation and cerebral hemodynamics. Magn Reson Med 30:715–723CrossRefPubMed

25.

Turner R, Le Bihan D, Moonen CTW, Despres D, Frank J (1991) Echo-planar time course MRI of cat brain oxygenation changes. Magn Reson Med 22:159–166CrossRefPubMed

26.

Kwong KK, Wanke I, Donahue KM, Davis TL (1995) EPI imaging of global increase of brain MR signal with breath-hold preceded by breathing O₂. Magn Reson Med 33:448–452CrossRefPubMed

27.

Kontos HA, Wei EP, Raper AJ, Rosenblum WI, Navari RM, Patterson JL (1978) Role of tissue hypoxia in local regulation of cerebral microcirculation. Am J Physiol 234:H582–H591PubMed

28.

Jezzard P, Heineman F, Taylor J, DesPres D, Wen H, Balaban RS, Turner R (1994) Comparison of EPI gradient-echo contrast changes in cat brain caused by respiratory challenges with direct simultaneous evaluation of cerebral oxygenation via a cranial window. NMR Biomed 7:35–44CrossRefPubMed

29.

Rostrup E, Larsson HBW, Toft PB, Garde K, Henriksen O (1995) Signal changes in gradient-echo images of human brain induced by hypo- and hyperoxia. NMR Biomed 8:41–47CrossRefPubMed

Title: T2 and T2* measurements of fetal brain oxygenation during hypoxia with MRI at 3T: correlation with fetal arterial blood oxygen saturation
Authors: Ulrike Wedegärtner
Hendrik Kooijman
Thomas Andreas
Nicola Beindorff
Kurt Hecher
Gerhard Adam
Publication date: 01-01-2010
Publisher: Springer-Verlag
Published in: European Radiology / Issue 1/2010
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-009-1513-4

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T2 and T2* measurements of fetal brain oxygenation during hypoxia with MRI at 3T: correlation with fetal arterial blood oxygen saturation

Abstract

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Abstract

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