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Open Access 01-04-2011

T-cell Subset Regulation in Atopy

Authors: Marek Jutel, Cezmi A. Akdis

Published in: Current Allergy and Asthma Reports | Issue 2/2011

Abstract

Presentation of processed allergen by antigen-presenting cells to T-helper (Th) lymphocytes, which is influenced costimulatory signals, cytokines, chemokines, and regulatory T cells (Tregs), determines the development of different types of T-cell immunity. The discovery of Tregs revolutionized the primary concepts of immune regulation interpreted within the framework of a binary Th1/Th2 paradigm. Tregs play a central role in the maintenance of peripheral homeostasis, the establishment of controlled immune responses, and the inhibition of allergen-specific effector cells. Recently, some other T-cell subsets appeared, including Th17 and Th9 cells, which control local tissue inflammation through upregulation of proinflammatory cytokines and chemokines. This review aims to discuss our understanding of the T-cell subset reciprocal interaction in atopy.

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Title: T-cell Subset Regulation in Atopy
Authors: Marek Jutel
Cezmi A. Akdis
Publication date: 01-04-2011
Publisher: Current Science Inc.
Published in: Current Allergy and Asthma Reports / Issue 2/2011
Print ISSN: 1529-7322
Electronic ISSN: 1534-6315
DOI: https://doi.org/10.1007/s11882-011-0178-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

T-cell Subset Regulation in Atopy

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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