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Open Access 01-10-2009 | Letter to the Editor

Systematic Review of Pharmacogenetic Warfarin Dosing

Authors: Rianne M. F. van Schie, MSc, Andrea L. Jorgensen, MSc, Anthonius de Boer, MD, PhD, Anke-Hilse Maitland-van der Zee, PharmD, PhD, for the EU-PACT study group

Published in: Journal of General Internal Medicine | Issue 10/2009

Excerpt

To the Editor: —In the article1 by Neudoerffer et al. the safety and efficacy of genotype-guided dosing of warfarin was described. The conclusion was that there is not sufficient evidence to support the use of pharmacogenetics to guide warfarin dosing and that additional clinical trials are necessary. An overview of these additional and ongoing clinical trials was given in Table 5. At least five ongoing clinical trials were identified, to which we would like to add a sixth randomized trial. Details of this study design are expected to be published soon. …

Neudoerffer Kangelaris K, Bent S, Nussbaum RL, Garcia DA, Tice JA. Genetic testing before anticoagulation? A systematic review of pharmacogenetic dosing of warfarin. J Gen Intern Med. 2009;24:656–64.CrossRef

Title: Systematic Review of Pharmacogenetic Warfarin Dosing
Authors: Rianne M. F. van Schie, MSc
Andrea L. Jorgensen, MSc
Anthonius de Boer, MD, PhD
Anke-Hilse Maitland-van der Zee, PharmD, PhD
for the EU-PACT study group
Publication date: 01-10-2009
Publisher: Springer-Verlag
Published in: Journal of General Internal Medicine / Issue 10/2009
Print ISSN: 0884-8734
Electronic ISSN: 1525-1497
DOI: https://doi.org/10.1007/s11606-009-1083-9

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