Skip to main content
Top
Published in: Intensive Care Medicine 4/2010

01-04-2010 | Review

Systematic review of paediatric alert criteria for identifying hospitalised children at risk of critical deterioration

Authors: Susan M. Chapman, Michael P. W. Grocott, Linda S. Franck

Published in: Intensive Care Medicine | Issue 4/2010

Login to get access

Abstract

Introduction

Unrecognised or untreated clinical deterioration can lead to serious adverse events, including cardiopulmonary arrest and unexpected death. Paediatric alert criteria aim to identify children with early signs of physiological instability that precede clinical deterioration so that experienced clinicians can intervene with the aim of reducing serious adverse events and improving outcome.

Purpose

To identify the number and nature of published paediatric alert criteria and evaluate their validity, reliability, clinical effectiveness and clinical utility.

Method

Systematic review of studies identified from electronic and citation searching and expert informants.

Results

Eleven studies fulfilled the inclusion criteria and described ten paediatric alert criteria. Six studies described the introduction and use of the paediatric alert criteria in practice, four examined the development and testing of the paediatric alert criteria, and one described both. There was marked variability across all aspects of the paediatric alert criteria, including the method of development, and the number and type of component parameters. Five studies explored the predictive validity of the paediatric alert criteria, but only three reported appropriate methodology. Only one study evaluated reliability, and none evaluated clinical utility of paediatric alert criteria.

Conclusions

Evidence supporting the validity, reliability and utility of paediatric alert criteria is weak. Studies are needed to determine which physiological parameters or combinations of parameters, best predict serious adverse events. Prospective evaluation of validity, reliability and utility is then needed before widespread adoption into clinical practice can be recommended.
Appendix
Available only for authorised users
Literature
1.
go back to reference Berg MD, Nadkarni VM, Zuercher M, Berg RA (2008) In-hospital pediatric cardiac arrest. Pediatr Clin North Am 55:589–604CrossRefPubMed Berg MD, Nadkarni VM, Zuercher M, Berg RA (2008) In-hospital pediatric cardiac arrest. Pediatr Clin North Am 55:589–604CrossRefPubMed
2.
go back to reference Lopez-Herce J, Garcia C, Dominguez P, Carrillo A, Rodriguez-Nunez A, Calvo C, Delgado MA (2004) Characteristics and outcome of cardiorespiratory arrest in children. Resuscitation 63:311–320CrossRefPubMed Lopez-Herce J, Garcia C, Dominguez P, Carrillo A, Rodriguez-Nunez A, Calvo C, Delgado MA (2004) Characteristics and outcome of cardiorespiratory arrest in children. Resuscitation 63:311–320CrossRefPubMed
3.
go back to reference Reis AG, Nadkarni V, Perondi MB, Grisi S, Berg RA (2002) A prospective investigation into the epidemiology of in-hospital pediatric cardiopulmonary resuscitation using the international Utstein reporting style. Pediatrics 109:200–209CrossRefPubMed Reis AG, Nadkarni V, Perondi MB, Grisi S, Berg RA (2002) A prospective investigation into the epidemiology of in-hospital pediatric cardiopulmonary resuscitation using the international Utstein reporting style. Pediatrics 109:200–209CrossRefPubMed
4.
go back to reference Suominen P, Olkkola KT, Voipio V, Korpela R, Palo R, Rasanen J (2000) Utstein style reporting of in-hospital paediatric cardiopulmonary resuscitation. Resuscitation 45:17–25CrossRefPubMed Suominen P, Olkkola KT, Voipio V, Korpela R, Palo R, Rasanen J (2000) Utstein style reporting of in-hospital paediatric cardiopulmonary resuscitation. Resuscitation 45:17–25CrossRefPubMed
5.
go back to reference Tibballs J, Kinney S (2006) A prospective study of outcome of in-patient paediatric cardiopulmonary arrest. Resuscitation 71:310–318CrossRefPubMed Tibballs J, Kinney S (2006) A prospective study of outcome of in-patient paediatric cardiopulmonary arrest. Resuscitation 71:310–318CrossRefPubMed
6.
go back to reference Buist MD, Jarmolowski E, Burton PR, Bernard SA, Waxman BP, Anderson J (1999) Recognising clinical instability in hospital patients before cardiac arrest or unplanned admission to intensive care. A pilot study in a tertiary-care hospital. Med J Aust 171:22–25PubMed Buist MD, Jarmolowski E, Burton PR, Bernard SA, Waxman BP, Anderson J (1999) Recognising clinical instability in hospital patients before cardiac arrest or unplanned admission to intensive care. A pilot study in a tertiary-care hospital. Med J Aust 171:22–25PubMed
7.
go back to reference Franklin C, Mathew J (1994) Developing strategies to prevent inhospital cardiac arrest: analyzing responses of physicians and nurses in the hours before the event. Crit Care Med 22:244–247PubMed Franklin C, Mathew J (1994) Developing strategies to prevent inhospital cardiac arrest: analyzing responses of physicians and nurses in the hours before the event. Crit Care Med 22:244–247PubMed
8.
go back to reference Sax FL, Charlson ME (1987) Medical patients at high risk for catastrophic deterioration. Crit Care Med 15:510–515PubMed Sax FL, Charlson ME (1987) Medical patients at high risk for catastrophic deterioration. Crit Care Med 15:510–515PubMed
9.
go back to reference Schein RM, Hazday N, Pena M, Ruben BH, Sprung CL (1990) Clinical antecedents to in-hospital cardiopulmonary arrest. Chest 98:1388–1392CrossRefPubMed Schein RM, Hazday N, Pena M, Ruben BH, Sprung CL (1990) Clinical antecedents to in-hospital cardiopulmonary arrest. Chest 98:1388–1392CrossRefPubMed
10.
go back to reference Haines C (2005) Acutely ill children within ward areas-care provision and possible development strategies. Nurs Crit Care 10:98–104CrossRefPubMed Haines C (2005) Acutely ill children within ward areas-care provision and possible development strategies. Nurs Crit Care 10:98–104CrossRefPubMed
11.
12.
go back to reference Tume L, Bullock I (2004) Early warning tools to identify children at risk of deterioration: a discussion. Paediatr Nurs 16:20–23PubMed Tume L, Bullock I (2004) Early warning tools to identify children at risk of deterioration: a discussion. Paediatr Nurs 16:20–23PubMed
13.
go back to reference Tume L (2007) The deterioration of children in ward areas in a specialist children’s hospital. Nurs Crit Care 12:12–19CrossRefPubMed Tume L (2007) The deterioration of children in ward areas in a specialist children’s hospital. Nurs Crit Care 12:12–19CrossRefPubMed
15.
go back to reference Tibballs J, van der Jagt EW (2008) Medical emergency and rapid response teams. Pediatr Clin North Am 55:989–1010CrossRefPubMed Tibballs J, van der Jagt EW (2008) Medical emergency and rapid response teams. Pediatr Clin North Am 55:989–1010CrossRefPubMed
16.
go back to reference University of York NHS Centre for Reviews and Dissemination (2009) Systematic reviews: CRD’s guidance for undertaking reviews in healthcare University of York NHS Centre for Reviews and Dissemination (2009) Systematic reviews: CRD’s guidance for undertaking reviews in healthcare
17.
go back to reference Gao H, McDonnell A, Harrison DA, Moore T, Adam S, Daly K, Esmonde L, Goldhill DR, Parry GJ, Rashidian A, Subbe CP, Harvey S (2007) Systematic review and evaluation of physiological track and trigger warning systems for identifying at-risk patients on the ward. Intens Care Med 33:667–679CrossRef Gao H, McDonnell A, Harrison DA, Moore T, Adam S, Daly K, Esmonde L, Goldhill DR, Parry GJ, Rashidian A, Subbe CP, Harvey S (2007) Systematic review and evaluation of physiological track and trigger warning systems for identifying at-risk patients on the ward. Intens Care Med 33:667–679CrossRef
19.
go back to reference Duncan H (2007) The paediatric early warning score. British J Intens Care 133–139 Duncan H (2007) The paediatric early warning score. British J Intens Care 133–139
20.
go back to reference Winberg H, Nilsson K, Aneman A (2008) Paediatric rapid response systems: a literature review. Acta Anaesthesiol Scand 52:890–896PubMedCrossRef Winberg H, Nilsson K, Aneman A (2008) Paediatric rapid response systems: a literature review. Acta Anaesthesiol Scand 52:890–896PubMedCrossRef
21.
go back to reference McGinn TG, Guyatt GH, Wyer PC, Naylor CD, Stiell IG, Richardson WS, for the Evidence-Based Medicine Working Group (2000) Users’ guides to the medical literature: XXII: how to use articles about clinical decision rules. JAMA (J Am Med Assoc) 284:79–84CrossRef McGinn TG, Guyatt GH, Wyer PC, Naylor CD, Stiell IG, Richardson WS, for the Evidence-Based Medicine Working Group (2000) Users’ guides to the medical literature: XXII: how to use articles about clinical decision rules. JAMA (J Am Med Assoc) 284:79–84CrossRef
22.
go back to reference Whiting P, Rutjes A, Reitsma J, Bossuyt P, Kleijnen J (2003) The development of QUADAS: a tool for the quality assessment of studies of diagnostic accuracy included in systematic reviews. BMC Med Res Methodol 3:25CrossRefPubMed Whiting P, Rutjes A, Reitsma J, Bossuyt P, Kleijnen J (2003) The development of QUADAS: a tool for the quality assessment of studies of diagnostic accuracy included in systematic reviews. BMC Med Res Methodol 3:25CrossRefPubMed
23.
go back to reference Hayden J, Cote P, Bombardier C (2006) Evaluation of the quality of prognosis studies in systematic reviews. Ann Intern Med 144:427–438PubMed Hayden J, Cote P, Bombardier C (2006) Evaluation of the quality of prognosis studies in systematic reviews. Ann Intern Med 144:427–438PubMed
24.
go back to reference Altman DG, Bland JM (1998) Statistics notes: time to event (survival) data. BMJ 317:468–469PubMed Altman DG, Bland JM (1998) Statistics notes: time to event (survival) data. BMJ 317:468–469PubMed
25.
go back to reference Brilli RJ, Gibson R, Luria JW, Wheeler TA, Shaw J, Linam M, Kheir J, McLain P, Lingsch T, Hall H, McBride M (2007) Implementation of a medical emergency team in a large pediatric teaching hospital prevents respiratory and cardiopulmonary arrests outside the intensive care unit. Pediatr Crit Care Med 8:236–246CrossRefPubMed Brilli RJ, Gibson R, Luria JW, Wheeler TA, Shaw J, Linam M, Kheir J, McLain P, Lingsch T, Hall H, McBride M (2007) Implementation of a medical emergency team in a large pediatric teaching hospital prevents respiratory and cardiopulmonary arrests outside the intensive care unit. Pediatr Crit Care Med 8:236–246CrossRefPubMed
26.
go back to reference Duncan H, Hutchison J, Parshuram CS (2006) The Pediatric Early Warning System score: a severity of illness score to predict urgent medical need in hospitalized children. J Crit Care 21:271–278CrossRefPubMed Duncan H, Hutchison J, Parshuram CS (2006) The Pediatric Early Warning System score: a severity of illness score to predict urgent medical need in hospitalized children. J Crit Care 21:271–278CrossRefPubMed
27.
go back to reference Edwards ED, Powell CV, Mason BW, Oliver A (2009) Prospective cohort study to test the predictability of the Cardiff and Vale paediatric early warning system. Arch Dis Child 94:602–606CrossRefPubMed Edwards ED, Powell CV, Mason BW, Oliver A (2009) Prospective cohort study to test the predictability of the Cardiff and Vale paediatric early warning system. Arch Dis Child 94:602–606CrossRefPubMed
28.
go back to reference Haines C, Perrott M, Weir P (2006) Promoting care for acutely ill children-development and evaluation of a paediatric early warning tool. Intensive Crit Care Nurs 22:73–81CrossRefPubMed Haines C, Perrott M, Weir P (2006) Promoting care for acutely ill children-development and evaluation of a paediatric early warning tool. Intensive Crit Care Nurs 22:73–81CrossRefPubMed
29.
go back to reference Hunt EA, Zimmer KP, Rinke ML, Shilkofski NA, Matlin C, Garger C, Dickson C, Miller MR (2008) Transition from a traditional code team to a medical emergency team and categorization of cardiopulmonary arrests in a children’s center. Arch Pediatr Adolesc Med 162:117–122CrossRefPubMed Hunt EA, Zimmer KP, Rinke ML, Shilkofski NA, Matlin C, Garger C, Dickson C, Miller MR (2008) Transition from a traditional code team to a medical emergency team and categorization of cardiopulmonary arrests in a children’s center. Arch Pediatr Adolesc Med 162:117–122CrossRefPubMed
30.
go back to reference Monaghan A (2005) Detecting and managing deterioration in children. Paediatr Nurs 17:32–35PubMed Monaghan A (2005) Detecting and managing deterioration in children. Paediatr Nurs 17:32–35PubMed
31.
go back to reference Sharek PJ, Parast LM, Leong K, Coombs J, Earnest K, Sullivan J, Frankel LR, Roth SJ (2007) Effect of a rapid response team on hospital-wide mortality and code rates outside the ICU in a Children’s Hospital. JAMA 298:2267–2274CrossRefPubMed Sharek PJ, Parast LM, Leong K, Coombs J, Earnest K, Sullivan J, Frankel LR, Roth SJ (2007) Effect of a rapid response team on hospital-wide mortality and code rates outside the ICU in a Children’s Hospital. JAMA 298:2267–2274CrossRefPubMed
32.
go back to reference Shilkofski NA, Hunt EA (2007) A pediatric medical emergency team manages a complex child with hypoxia and worried parent. Jt Comm J Qual Patient Saf 33:236–241PubMed Shilkofski NA, Hunt EA (2007) A pediatric medical emergency team manages a complex child with hypoxia and worried parent. Jt Comm J Qual Patient Saf 33:236–241PubMed
33.
go back to reference Tibballs J, Kinney S, Duke T, Oakley E, Hennessy M (2005) Reduction of paediatric in-patient cardiac arrest and death with a medical emergency team: preliminary results. Arch Dis Child 90:1148–1152CrossRefPubMed Tibballs J, Kinney S, Duke T, Oakley E, Hennessy M (2005) Reduction of paediatric in-patient cardiac arrest and death with a medical emergency team: preliminary results. Arch Dis Child 90:1148–1152CrossRefPubMed
34.
go back to reference Tibballs J, Kinney S (2009) Reduction of hospital mortality and of preventable cardiac arrest and death with increased survival on introduction of a pediatric medical emergency team. Pediatr Crit Care Med 10:306–312CrossRefPubMed Tibballs J, Kinney S (2009) Reduction of hospital mortality and of preventable cardiac arrest and death with increased survival on introduction of a pediatric medical emergency team. Pediatr Crit Care Med 10:306–312CrossRefPubMed
35.
go back to reference Tucker KM, Brewer TL, Baker RB, Demeritt B, Vossmeyer MT (2009) Prospective evaluation of a pediatric inpatient early warning scoring system. J Spec Pediatr Nurs 14:79–85CrossRefPubMed Tucker KM, Brewer TL, Baker RB, Demeritt B, Vossmeyer MT (2009) Prospective evaluation of a pediatric inpatient early warning scoring system. J Spec Pediatr Nurs 14:79–85CrossRefPubMed
36.
go back to reference Fraser DD, Singh RN, Frewen T (2006) The PEWS score: potential calling criteria for critical care response teams in children’s hospitals. J Crit Care 21:278–279CrossRefPubMed Fraser DD, Singh RN, Frewen T (2006) The PEWS score: potential calling criteria for critical care response teams in children’s hospitals. J Crit Care 21:278–279CrossRefPubMed
37.
go back to reference Tibballs J, Kinney S (2006) Evaluation of a paediatric early warning tool—claims unsubstantiated. Intensive Crit Care Nurs 22:315–316CrossRefPubMed Tibballs J, Kinney S (2006) Evaluation of a paediatric early warning tool—claims unsubstantiated. Intensive Crit Care Nurs 22:315–316CrossRefPubMed
38.
go back to reference Santiano N, Young L, Hillman K, Parr M, Jayasinghe S, Baramy LS, Stevenson J, Heath T, Chan C, Claire M, Hanger G (2009) Analysis of Medical Emergency Team calls comparing subjective to “objective” call criteria. Resuscitation 80:44–49CrossRefPubMed Santiano N, Young L, Hillman K, Parr M, Jayasinghe S, Baramy LS, Stevenson J, Heath T, Chan C, Claire M, Hanger G (2009) Analysis of Medical Emergency Team calls comparing subjective to “objective” call criteria. Resuscitation 80:44–49CrossRefPubMed
39.
go back to reference Duncan HP (2007) Survey of early identification systems to identify inpatient children at risk of physiological deterioration. Arch Dis Child 92:828CrossRefPubMed Duncan HP (2007) Survey of early identification systems to identify inpatient children at risk of physiological deterioration. Arch Dis Child 92:828CrossRefPubMed
40.
go back to reference VandenBerg SD, Hutchison JS, Parshuram CS, Lacroix J, Farrell C, Joffe A, Duncan H, Parkin P, Beyene J (2007) A cross-sectional survey of levels of care and response mechanisms for evolving critical illness in hospitalized children. Pediatrics 119:e940–e946CrossRefPubMed VandenBerg SD, Hutchison JS, Parshuram CS, Lacroix J, Farrell C, Joffe A, Duncan H, Parkin P, Beyene J (2007) A cross-sectional survey of levels of care and response mechanisms for evolving critical illness in hospitalized children. Pediatrics 119:e940–e946CrossRefPubMed
41.
go back to reference Hillman K, Chen J, Cretikos M, Bellomo R, Brown D, Doig G, Finfer S, Flabouris A (2005) Introduction of the medical emergency team (MET) system: a cluster-randomised controlled trial. Lancet 365:2091–2097CrossRefPubMed Hillman K, Chen J, Cretikos M, Bellomo R, Brown D, Doig G, Finfer S, Flabouris A (2005) Introduction of the medical emergency team (MET) system: a cluster-randomised controlled trial. Lancet 365:2091–2097CrossRefPubMed
42.
go back to reference NICE Centre for Clinical Guidance (2008) Acutely ill patients in hospital: recognition of and response to acute illness in adults in hospital. National Institute for Health and Clinical Excellence, London NICE Centre for Clinical Guidance (2008) Acutely ill patients in hospital: recognition of and response to acute illness in adults in hospital. National Institute for Health and Clinical Excellence, London
43.
go back to reference Laupacis A, Sekar N, Stiell IG (1997) Clinical prediction rules. A review and suggested modifications of methodological standards. JAMA 277:488–494CrossRefPubMed Laupacis A, Sekar N, Stiell IG (1997) Clinical prediction rules. A review and suggested modifications of methodological standards. JAMA 277:488–494CrossRefPubMed
44.
go back to reference Tarassenko L, Hann A, Young D (2006) Integrated monitoring and analysis for early warning of patient deterioration. Br J Anaesth 97:64–68CrossRefPubMed Tarassenko L, Hann A, Young D (2006) Integrated monitoring and analysis for early warning of patient deterioration. Br J Anaesth 97:64–68CrossRefPubMed
Metadata
Title
Systematic review of paediatric alert criteria for identifying hospitalised children at risk of critical deterioration
Authors
Susan M. Chapman
Michael P. W. Grocott
Linda S. Franck
Publication date
01-04-2010
Publisher
Springer-Verlag
Published in
Intensive Care Medicine / Issue 4/2010
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-009-1715-x

Other articles of this Issue 4/2010

Intensive Care Medicine 4/2010 Go to the issue