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01-04-2012 | Dementias - Short communication

Synaptic protein expression is regulated by a pro-oxidant diet in APPxPS1 mice

Authors: Martin Broadstock, Rikke Lewinsky, Emma L. Jones, Cathy Mitchelmore, David R. Howlett, Paul T. Francis

Published in: Journal of Neural Transmission | Issue 4/2012

Abstract

Dietary factors may play a role in Alzheimer’s disease (AD) pathogenesis. In an effort to recapitulate some of the synaptic protein changes observed in the disease, AD transgenic and wild-type mice were fed either a normal or pro-oxidant diet for 3 months from three months of age. Pro-oxidant diet treatment resulted in altered expression of vesicular glutamate transporter-1 and glutamine synthetase, suggesting changes in glutamatergic synaptic function, and increased expression of urokinase plasminogen activator receptor, possibly reflecting oxidative stress.

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Title: Synaptic protein expression is regulated by a pro-oxidant diet in APPxPS1 mice
Authors: Martin Broadstock
Rikke Lewinsky
Emma L. Jones
Cathy Mitchelmore
David R. Howlett
Paul T. Francis
Publication date: 01-04-2012
Publisher: Springer Vienna
Published in: Journal of Neural Transmission / Issue 4/2012
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-011-0727-1

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Synaptic protein expression is regulated by a pro-oxidant diet in APPxPS1 mice

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