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Published in: Archives of Women's Mental Health 2/2017

01-04-2017 | Original Article

Symptoms of anxiety and depression during pregnancy and their association with low birth weight in Chinese women: a nested case control study

Authors: Shaoping Yang, Rong Yang, Shengwen Liang, Jing Wang, Nancy L. Weaver, Ke Hu, Ronghua Hu, Edwin Trevathan, Zhen Huang, Yiming Zhang, Ting Yin, Jen Jen Chang, Jinzhu zhao, Longjiao Shen, Guanghui Dong, Tongzhang Zheng, Shunqing Xu, Zhengmin Qian, Bin Zhang

Published in: Archives of Women's Mental Health | Issue 2/2017

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Abstract

This study is a nested case control study from a population-based cohort study conducted in Wuhan, China. The aim is to estimate the association between symptoms of depression during pregnancy (DDP), anxiety during pregnancy(ADP), and depression with anxiety during pregnancy (DADP) and low birth weight (LBW) and to examine the extent to which preterm birth (PTB) moderates these associations. Logistic regression analyses were used to model associations between DDP, ADP, and DADP and LBW. Models were stratified by the presence or absence of PTB to examine moderating effects. From the cohort study, 2853 had a LBW baby (cases); 5457 pregnant women served as controls. Women with DDP or ADP only were not at higher risk of having a LBW baby, but DADP was associated with increased risk of LBW (crude OR 1.41, 95% CI 1.17–1.70; adjusted OR 1.29, 95% CI 1.07–1.57), and the significant association was particularly evident between DADP and LBW in PTB, but not in full-term births. Our data suggests that DADP is related to an increased risk of LBW and that this association is most present in PTBs.
Literature
go back to reference Anderson L, Sundstrom-Poromaa I, Bixo M, Wulff M, Bondestam K, Astrom M (2003) Point prevalence of psychiatric disorders during the second trimester of pregnancy: a population-based study. Am J Obstet Gynecol 189:148–154CrossRef Anderson L, Sundstrom-Poromaa I, Bixo M, Wulff M, Bondestam K, Astrom M (2003) Point prevalence of psychiatric disorders during the second trimester of pregnancy: a population-based study. Am J Obstet Gynecol 189:148–154CrossRef
go back to reference Andersson L, Sundström-Poromaa I, Wulff M, Åström M, Bixo M (2004) Neonatal outcome following maternal antenatal depression and anxiety: a population-based study. Am J Epidemiol 159:872–881CrossRefPubMed Andersson L, Sundström-Poromaa I, Wulff M, Åström M, Bixo M (2004) Neonatal outcome following maternal antenatal depression and anxiety: a population-based study. Am J Epidemiol 159:872–881CrossRefPubMed
go back to reference Andersson L, Sundström-Poromaa I, Wulff M, Aström M, Bixo M (2014) Neonatal outcome following maternal antenatal depression and anxiety: a population-based study. Am J Epidemiol 159(9):872–881CrossRef Andersson L, Sundström-Poromaa I, Wulff M, Aström M, Bixo M (2014) Neonatal outcome following maternal antenatal depression and anxiety: a population-based study. Am J Epidemiol 159(9):872–881CrossRef
go back to reference Berle JO, Mykletun A, Daltveit AK, Rasmussen S, Holsten F, Dahl AA (2005) Neonatal outcomes in offspring of women with anxiety and depression during pregnancy. A linkage study from The Nord-Trondelag Health Study (HUNT) and Medical Birth Registry of Norway. Arch Women Ment Health 8:181–189CrossRef Berle JO, Mykletun A, Daltveit AK, Rasmussen S, Holsten F, Dahl AA (2005) Neonatal outcomes in offspring of women with anxiety and depression during pregnancy. A linkage study from The Nord-Trondelag Health Study (HUNT) and Medical Birth Registry of Norway. Arch Women Ment Health 8:181–189CrossRef
go back to reference Biswas R, Dasgupta A, Sinha RN, Chaudhuri RN (2008) An epidemiological study of low birth weight newborns in the district of Puruliya, West Bengal. Indian J Public Health 52:65–71PubMed Biswas R, Dasgupta A, Sinha RN, Chaudhuri RN (2008) An epidemiological study of low birth weight newborns in the district of Puruliya, West Bengal. Indian J Public Health 52:65–71PubMed
go back to reference Chung TK, Lau TK, Yip AS, Chiu HF, Lee DT (2001) Antepartum depressive symptomatology is associated with adverse obstetric and neonatal outcomes. Psychosom Med 63(5):830–834CrossRefPubMed Chung TK, Lau TK, Yip AS, Chiu HF, Lee DT (2001) Antepartum depressive symptomatology is associated with adverse obstetric and neonatal outcomes. Psychosom Med 63(5):830–834CrossRefPubMed
go back to reference Dayan J, Creveuil C, Marks MN, Conroy S, Herlicoviez M, Dreyfus M, Tordjman S (2006) Prenatal depression, prenatal anxiety, and spontaneous preterm birth: a prospective cohort study among women with early and regular care. Psychosom Med 68(6):938–946CrossRefPubMed Dayan J, Creveuil C, Marks MN, Conroy S, Herlicoviez M, Dreyfus M, Tordjman S (2006) Prenatal depression, prenatal anxiety, and spontaneous preterm birth: a prospective cohort study among women with early and regular care. Psychosom Med 68(6):938–946CrossRefPubMed
go back to reference Ding X-X, Wu YL, Xu S-J, Jia X-M, Zhu R-P, Huang K, Zhang S-F, Hao J-H, Zhu P, Tao F-B (2014) Maternal anxiety during pregnancy and adverse birth outcomes: a systematic review and meta-analysis of prospective cohort studies. J Affect Disord 159:103–110CrossRefPubMed Ding X-X, Wu YL, Xu S-J, Jia X-M, Zhu R-P, Huang K, Zhang S-F, Hao J-H, Zhu P, Tao F-B (2014) Maternal anxiety during pregnancy and adverse birth outcomes: a systematic review and meta-analysis of prospective cohort studies. J Affect Disord 159:103–110CrossRefPubMed
go back to reference Elsenbruch S, Benson S, Rücke M, Rose M, Dudenhausen J, Pincus-Knackstedt MK, Klapp BF, Arck PC (2007) Social support during pregnancy: effects on maternal depressive symptoms, smoking and pregnancy outcome. Hum Reprod 22(3):869–877CrossRefPubMed Elsenbruch S, Benson S, Rücke M, Rose M, Dudenhausen J, Pincus-Knackstedt MK, Klapp BF, Arck PC (2007) Social support during pregnancy: effects on maternal depressive symptoms, smoking and pregnancy outcome. Hum Reprod 22(3):869–877CrossRefPubMed
go back to reference Faisal-Cury A, Rossi Menezes P (2007) Prevalence of anxiety and depression during pregnancy in a private setting sample. Arch Womens Ment Health 10:25–32CrossRefPubMed Faisal-Cury A, Rossi Menezes P (2007) Prevalence of anxiety and depression during pregnancy in a private setting sample. Arch Womens Ment Health 10:25–32CrossRefPubMed
go back to reference Field T, Diego M, Hernandez-Reif M, Schanberg S, Kuhn C, Yando R, Bendell D (2003) Pregnancy anxiety and comorbid depression and anger: effects on the fetus and neonate. Depress Anxiety 17:140–151CrossRefPubMed Field T, Diego M, Hernandez-Reif M, Schanberg S, Kuhn C, Yando R, Bendell D (2003) Pregnancy anxiety and comorbid depression and anger: effects on the fetus and neonate. Depress Anxiety 17:140–151CrossRefPubMed
go back to reference Field T, Diego M, Hernandez-Reif M, Figueiredo B, Deeds O, Ascencio A, Schanberg S, Kuhn C (2010) Comorbid depression and anxiety effects on pregnancy and neonatal outcome. Infant Behav Dev 33(1):23–37CrossRefPubMed Field T, Diego M, Hernandez-Reif M, Figueiredo B, Deeds O, Ascencio A, Schanberg S, Kuhn C (2010) Comorbid depression and anxiety effects on pregnancy and neonatal outcome. Infant Behav Dev 33(1):23–37CrossRefPubMed
go back to reference Fisher J, Tran T, La B, Kriitmaa K, Rosenthal D, Tran T (2010) Common perinatal mental disorders in northern Viet Nam: community prevalence and health care use. Bull World Health Organ 88:737–745CrossRefPubMedPubMedCentral Fisher J, Tran T, La B, Kriitmaa K, Rosenthal D, Tran T (2010) Common perinatal mental disorders in northern Viet Nam: community prevalence and health care use. Bull World Health Organ 88:737–745CrossRefPubMedPubMedCentral
go back to reference Goldenberge RL, Culhane JF (2007) Low birth weight in the United States. Am J Clin Nutr 85(suppl):584S–590S Goldenberge RL, Culhane JF (2007) Low birth weight in the United States. Am J Clin Nutr 85(suppl):584S–590S
go back to reference Grigoriadis S, VonderPorten EH, Mamisashvili L, Tomlinson G, Dennis CL, Koren G, Steiner M, Mousmanis P, Cheung A, Radford K, Martinovic J, Ross LE (2013) The impact of maternal depression during pregnancy on perinatal outcomes: a systematic review and meta-analysis. J Clin Psychiatry 74(4):e321–e341CrossRefPubMed Grigoriadis S, VonderPorten EH, Mamisashvili L, Tomlinson G, Dennis CL, Koren G, Steiner M, Mousmanis P, Cheung A, Radford K, Martinovic J, Ross LE (2013) The impact of maternal depression during pregnancy on perinatal outcomes: a systematic review and meta-analysis. J Clin Psychiatry 74(4):e321–e341CrossRefPubMed
go back to reference Haugen M, Brantsæter AL, Winkvist A, Lissner L, Alexander J, Oftedal B, Magnus P, Meltzer HM (2014) Associations of pre-pregnancy body mass index and gestational weight gain with pregnancy outcome and postpartum weight retention: a prospective observational cohort study BMC Pregnancy Childbirth. 14:201. doi:10.1186/1471-2393-14-201 Haugen M, Brantsæter AL, Winkvist A, Lissner L, Alexander J, Oftedal B, Magnus P, Meltzer HM (2014) Associations of pre-pregnancy body mass index and gestational weight gain with pregnancy outcome and postpartum weight retention: a prospective observational cohort study BMC Pregnancy Childbirth. 14:201. doi:10.​1186/​1471-2393-14-201
go back to reference Ibanez G, Charles M-A, Forhan A, Magnin G, Thiebaugeorges O, Kaminski M, Saurel-Cubizolles M-J, EDEN Mother–Child Cohort Study Group (2012) Depression and anxiety in women during pregnancy and neonatal outcome: data from the EDEN mother–child cohort. Early Hum Dev 88:643–649CrossRefPubMed Ibanez G, Charles M-A, Forhan A, Magnin G, Thiebaugeorges O, Kaminski M, Saurel-Cubizolles M-J, EDEN Mother–Child Cohort Study Group (2012) Depression and anxiety in women during pregnancy and neonatal outcome: data from the EDEN mother–child cohort. Early Hum Dev 88:643–649CrossRefPubMed
go back to reference Kessler RC, Merikangas KR, Wang PS (2007) Prevalence, comorbidity, and service utilization for mood disorders in the United States at the beginning of the twenty-first century. Annu Rev Clin Psychol 3:137–158CrossRefPubMed Kessler RC, Merikangas KR, Wang PS (2007) Prevalence, comorbidity, and service utilization for mood disorders in the United States at the beginning of the twenty-first century. Annu Rev Clin Psychol 3:137–158CrossRefPubMed
go back to reference Lamers F, Comijs HC, Spinhoven P, Anton J, Willem A, Frans G, Aartjan T, Brenda W (2011a) Comorbidity patterns of anxiety and depressive disorders in a large cohort study: the Netherlands Study of Depression and Anxiety (NESDA). J Clin Psychiatry 72(3):341–348CrossRefPubMed Lamers F, Comijs HC, Spinhoven P, Anton J, Willem A, Frans G, Aartjan T, Brenda W (2011a) Comorbidity patterns of anxiety and depressive disorders in a large cohort study: the Netherlands Study of Depression and Anxiety (NESDA). J Clin Psychiatry 72(3):341–348CrossRefPubMed
go back to reference Lamers F, van Oppen P, Comijs HC, Smit JH, Spinhoven P, van Balkom AJ, Nolen WA, Zitman FG, Beekman AT, Penninx BW (2011b) Comorbidity patterns of anxiety and depressive disorders in a large cohort study: the Netherlands Study of Depression and Anxiety (NESDA). J Clin Psychiatry 72(3):341–348CrossRefPubMed Lamers F, van Oppen P, Comijs HC, Smit JH, Spinhoven P, van Balkom AJ, Nolen WA, Zitman FG, Beekman AT, Penninx BW (2011b) Comorbidity patterns of anxiety and depressive disorders in a large cohort study: the Netherlands Study of Depression and Anxiety (NESDA). J Clin Psychiatry 72(3):341–348CrossRefPubMed
go back to reference Larsson C, Sydsjö G, Josefsson A (2004) Health, sociodemographic data, and pregnancy outcome in women with antepartum depressive symptoms. Obstet Gynecol 104(3):459–466CrossRefPubMed Larsson C, Sydsjö G, Josefsson A (2004) Health, sociodemographic data, and pregnancy outcome in women with antepartum depressive symptoms. Obstet Gynecol 104(3):459–466CrossRefPubMed
go back to reference Lawn Lawn JE, Cousens S, Zupan J (2005) Lancet Neonatal Survival Steering Team. 4 million neonatal deaths: when? Where? Why? Lancet 365(9462):891–900CrossRefPubMed Lawn Lawn JE, Cousens S, Zupan J (2005) Lancet Neonatal Survival Steering Team. 4 million neonatal deaths: when? Where? Why? Lancet 365(9462):891–900CrossRefPubMed
go back to reference Martini J, Knappe S, Beesdo-Baum K, Lieb R, Wittchen H-U (2010) Anxiety disorders before birth and self-perceived distress during pregnancy: associations with maternal depression and obstetric, neonatal and early childhood outcomes. Early Hum Dev 86:305–310CrossRefPubMed Martini J, Knappe S, Beesdo-Baum K, Lieb R, Wittchen H-U (2010) Anxiety disorders before birth and self-perceived distress during pregnancy: associations with maternal depression and obstetric, neonatal and early childhood outcomes. Early Hum Dev 86:305–310CrossRefPubMed
go back to reference Nasreen HE, Kabir ZN, Forsell Y, Edhborg M (2010) Low birth weight in offspring of women with depressive and anxiety symptoms during pregnancy: results from a population based study in Bangladesh. BMC Public Health 10:515CrossRefPubMedPubMedCentral Nasreen HE, Kabir ZN, Forsell Y, Edhborg M (2010) Low birth weight in offspring of women with depressive and anxiety symptoms during pregnancy: results from a population based study in Bangladesh. BMC Public Health 10:515CrossRefPubMedPubMedCentral
go back to reference Nasreen HE, Kabir ZN, Forsell Y, Edhborg M (2011) Prevalence and associated factors of depressive and anxiety symptoms during pregnancy: a population based study in rural Bangladesh. BMC Womens Health 11:22–31CrossRefPubMedPubMedCentral Nasreen HE, Kabir ZN, Forsell Y, Edhborg M (2011) Prevalence and associated factors of depressive and anxiety symptoms during pregnancy: a population based study in rural Bangladesh. BMC Womens Health 11:22–31CrossRefPubMedPubMedCentral
go back to reference Neggers Y, Goldenberg R, Cliver S, Hauth J (2006) The relationship between psychosocial profile, health practices, and pregnancy outcomes. Acta Obstet Gynecol Scand 85(3):277–285CrossRefPubMed Neggers Y, Goldenberg R, Cliver S, Hauth J (2006) The relationship between psychosocial profile, health practices, and pregnancy outcomes. Acta Obstet Gynecol Scand 85(3):277–285CrossRefPubMed
go back to reference Niemi M, Falkenberg T, Petzold M, Chuc NTK, Patel V (2013) Symptoms of antenatal common mental disorders, preterm birth and low birthweight: a prospective cohort study in a semi-rural district of Vietnam. Trop Med Int Health 18(6):687–695CrossRefPubMed Niemi M, Falkenberg T, Petzold M, Chuc NTK, Patel V (2013) Symptoms of antenatal common mental disorders, preterm birth and low birthweight: a prospective cohort study in a semi-rural district of Vietnam. Trop Med Int Health 18(6):687–695CrossRefPubMed
go back to reference Rahman A, Iqbal Z, Bunn J, Lovel H, Harrington R (2004) Impact of maternal depression on infant nutritional status and illness: a cohort study. Arch Gen Psychiatry 61(9):946–952CrossRefPubMed Rahman A, Iqbal Z, Bunn J, Lovel H, Harrington R (2004) Impact of maternal depression on infant nutritional status and illness: a cohort study. Arch Gen Psychiatry 61(9):946–952CrossRefPubMed
go back to reference Rondó PH, Ferreira RF, Nogueira F, Ribeiro MC, Lobert H, Artes R (2003) Maternal psychological stress and distress as predictors of low birth weight, prematurity and intrauterine growth retardation. Eur J Clin Nutr 57(2):266–272CrossRefPubMed Rondó PH, Ferreira RF, Nogueira F, Ribeiro MC, Lobert H, Artes R (2003) Maternal psychological stress and distress as predictors of low birth weight, prematurity and intrauterine growth retardation. Eur J Clin Nutr 57(2):266–272CrossRefPubMed
go back to reference Steer RA, Scholl TO, Hediger ML, Fischer RL (1992) Self-reported depression and negative pregnancy outcomes. J Clin Epidemiol 45(10):1093–1099CrossRefPubMed Steer RA, Scholl TO, Hediger ML, Fischer RL (1992) Self-reported depression and negative pregnancy outcomes. J Clin Epidemiol 45(10):1093–1099CrossRefPubMed
go back to reference Stevens-Simon C, Orleans M (1999) Low-birth weight prevention programs: the enigma of failure. BIRTH 26(3):184–186CrossRefPubMed Stevens-Simon C, Orleans M (1999) Low-birth weight prevention programs: the enigma of failure. BIRTH 26(3):184–186CrossRefPubMed
go back to reference Tony C, Tze L, Alexander Y, Helen C, Dominic L (2001) Antepartum depressive symptomatology is associated with adverse obstetric and neonatal outcomes. Psychosom Med 63:830–834CrossRef Tony C, Tze L, Alexander Y, Helen C, Dominic L (2001) Antepartum depressive symptomatology is associated with adverse obstetric and neonatal outcomes. Psychosom Med 63:830–834CrossRef
go back to reference Vikrampatel, Prince M (2006) Maternal psychologicalmorbidity and low birthweight in India. Br J Psychiatry 188:284–285CrossRef Vikrampatel, Prince M (2006) Maternal psychologicalmorbidity and low birthweight in India. Br J Psychiatry 188:284–285CrossRef
go back to reference Weck RL, Paulose T, Flaws J (2008) Impact of environmental factors and poverty on pregnancy outcomes. Clin Gynecol 51(2):349–359CrossRef Weck RL, Paulose T, Flaws J (2008) Impact of environmental factors and poverty on pregnancy outcomes. Clin Gynecol 51(2):349–359CrossRef
go back to reference World Health Organization (1993) International statistics classification of diseases and related health problems. 10th revision, vol 2. WHO, Geneva World Health Organization (1993) International statistics classification of diseases and related health problems. 10th revision, vol 2. WHO, Geneva
go back to reference Young EA, Abelson JL, Cameron OG (2004) Effect of comorbid anxiety disorders on the hypothalamic–pituitary–adrenal axis response to a social stressor in major depression. Biol Psychiatry 56:113–120CrossRefPubMed Young EA, Abelson JL, Cameron OG (2004) Effect of comorbid anxiety disorders on the hypothalamic–pituitary–adrenal axis response to a social stressor in major depression. Biol Psychiatry 56:113–120CrossRefPubMed
go back to reference Zhao Y, Li M, Chen Y, Wei YP, Fen Q (2006) The states and effect factors of anxiety and depression during pregnant women. J Pract Obstet Gynecol 22(10):608–610 (Chinese edition) Zhao Y, Li M, Chen Y, Wei YP, Fen Q (2006) The states and effect factors of anxiety and depression during pregnant women. J Pract Obstet Gynecol 22(10):608–610 (Chinese edition)
Metadata
Title
Symptoms of anxiety and depression during pregnancy and their association with low birth weight in Chinese women: a nested case control study
Authors
Shaoping Yang
Rong Yang
Shengwen Liang
Jing Wang
Nancy L. Weaver
Ke Hu
Ronghua Hu
Edwin Trevathan
Zhen Huang
Yiming Zhang
Ting Yin
Jen Jen Chang
Jinzhu zhao
Longjiao Shen
Guanghui Dong
Tongzhang Zheng
Shunqing Xu
Zhengmin Qian
Bin Zhang
Publication date
01-04-2017
Publisher
Springer Vienna
Published in
Archives of Women's Mental Health / Issue 2/2017
Print ISSN: 1434-1816
Electronic ISSN: 1435-1102
DOI
https://doi.org/10.1007/s00737-016-0697-2

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