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Metabolic Brain Disease
Published in: Metabolic Brain Disease 1/2015

Open Access 01-02-2015 | Research Article

Sweet grass protection against oxidative stress formation in the rat brain

Authors: Wojciech Łuczaj, Iwona Jarocka-Karpowicz, Katarzyna Bielawska, Elżbieta Skrzydlewska

Published in: Metabolic Brain Disease | Issue 1/2015

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Abstract

The aims of this study were to investigate the influences of sweet grass on chronic ethanol-induced oxidative stress in the rat brain. Chronic ethanol intoxication decreased activities and antioxidant levels resulting in enhanced lipid peroxidation. Administration of sweet grass solution to ethanol-intoxicated rats partially normalized the activity activities of Cu,Zn-superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase, as well as levels of reduced glutathione and vitamins C, E, and A. Sweet grass also protected unsaturated fatty acids (arachidonic and docosahexaenoic) from oxidations and decreased levels of lipid peroxidation products: 4-hydroxynonenal, isoprostanes, and neuroprostanes. The present in vivo study confirms previous in vitro data demonstrating the bioactivity of sweet grass and suggests a possible role for sweet grass in human health protection from deleterious consequences associated with oxidative stress formation.
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Metadata
Title
Sweet grass protection against oxidative stress formation in the rat brain
Authors
Wojciech Łuczaj
Iwona Jarocka-Karpowicz
Katarzyna Bielawska
Elżbieta Skrzydlewska
Publication date
01-02-2015
Publisher
Springer US
Published in
Metabolic Brain Disease / Issue 1/2015
Print ISSN: 0885-7490
Electronic ISSN: 1573-7365
DOI
https://doi.org/10.1007/s11011-014-9599-z

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