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01-08-2017 | Original Article

Swallowing Preparation and Execution: Insights from a Delayed-Response Functional Magnetic Resonance Imaging (fMRI) Study

Authors: Jillian A. Toogood, Rebecca C. Smith, Todd K. Stevens, Joe S. Gati, Ravi S. Menon, Julie Theurer, Sarah Weisz, Rebecca H. Affoo, Ruth E. Martin

Published in: Dysphagia | Issue 4/2017

Abstract

The present study sought to elucidate the functional contributions of sub-regions of the swallowing neural network in swallowing preparation and swallowing motor execution. Seven healthy volunteers participated in a delayed-response, go, no-go functional magnetic resonance imaging study involving four semi-randomly ordered activation tasks: (i) “prepare to swallow,” (ii) “voluntary saliva swallow,” (iii) “do not prepare to swallow,” and (iv) “do not swallow.” Results indicated that brain activation was significantly greater during swallowing preparation, than during swallowing execution, within the rostral and intermediate anterior cingulate cortex bilaterally, premotor cortex (left > right hemisphere), pericentral cortex (left > right hemisphere), and within several subcortical nuclei including the bilateral thalamus, caudate, and putamen. In contrast, activation within the bilateral insula and the left dorsolateral pericentral cortex was significantly greater in relation to swallowing execution, compared with swallowing preparation. Still other regions, including a more inferior ventrolateral pericentral area, and adjoining Brodmann area 43 bilaterally, and the supplementary motor area, were activated in relation to both swallowing preparation and execution. These findings support the view that the preparation, and subsequent execution, of swallowing are mediated by a cascading pattern of activity within the sub-regions of the bilateral swallowing neural network.

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Title: Swallowing Preparation and Execution: Insights from a Delayed-Response Functional Magnetic Resonance Imaging (fMRI) Study
Authors: Jillian A. Toogood
Rebecca C. Smith
Todd K. Stevens
Joe S. Gati
Ravi S. Menon
Julie Theurer
Sarah Weisz
Rebecca H. Affoo
Ruth E. Martin
Publication date: 01-08-2017
Publisher: Springer US
Published in: Dysphagia / Issue 4/2017
Print ISSN: 0179-051X
Electronic ISSN: 1432-0460
DOI: https://doi.org/10.1007/s00455-017-9794-2

At a glance: The STEP trials

Springer Medicine

Swallowing Preparation and Execution: Insights from a Delayed-Response Functional Magnetic Resonance Imaging (fMRI) Study

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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