Published in:
Open Access
01-02-2011 | Poster presentation
Suspended animation-inducer hydrogen sulphide protects against organ injury during endotoxemia, but aggravates systemic inflammation
Authors:
H Aslami, C Beurskens, F De Beer, M Kuipers, M Schultz, N Juffermans
Published in:
Critical Care
|
Special Issue 1/2011
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Excerpt
A suspended animation-like state induced by hydrogen sulphide (H2S) was shown before to protect lungs from ventilator-induced lung injury by reducing metabolism and inflammation. This beneficial effect of H2S seems promising, but the effects of H2S during prolonged infusion are unknown. We hypothesized that reducing metabolism in a rat model of LPS-induced systemic inflammation during 8 hours is more protective than during 4 hours. …