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Strahlentherapie und Onkologie
Published in: Strahlentherapie und Onkologie 1/2014

01-01-2014 | Original article

Survival and prognostic factors in non-small cell lung cancer patients with spinal bone metastases

A retrospective analysis of 303 patients

Authors: H. Rief, MD BSc, T. Muley, T. Bruckner, T. Welzel, S. Rieken, M. Bischof, K. Lindel, S.E. Combs, J. Debus

Published in: Strahlentherapie und Onkologie | Issue 1/2014

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Abstract

Background and purpose

For palliative care of spinal bone metastases, stability assessment is of crucial importance. Pathological fractures, instability-related patient immobility and the extent of bone metastasis have been reported to affect patient outcome and these parameters have therefore been used for treatment stratification. We report on stability-dependent fracture and survival rates in over 300 non-small cell lung cancer (NSCLC) patients.

Materials and methods

Data from 303 patients with 868 osteolytic metastases treated with radiotherapy (RT) between 2000 and 2012 were evaluated retrospectively.

Results

In NSCLC patients with bone metastases only, the retrospective 6- and 12-month overall survival (OS) rates were 76.7 and 47.2 %, respectively. In patients with additional non-bone distant metastases, these values were 60.0 and 34.0 %, respectively. Survival rates were significantly lower in patients with multiple bone metastases and in those suffering pathological fractures (p = 0.017). No significant impact of histological type, location of spinal lesions or treatment regime was detected. Furthermore, stability assessment revealed no influence of vertebral column stability on patient outcome (p = 0.739).

Conclusion

Our analysis demonstrated a correlation between the pathological fractures of bone lesions, the number of bone metastases, additional distant metastases and survival. The results offer a rationale for future prospective investigations.
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Metadata
Title
Survival and prognostic factors in non-small cell lung cancer patients with spinal bone metastases
A retrospective analysis of 303 patients
Authors
H. Rief, MD BSc
T. Muley
T. Bruckner
T. Welzel
S. Rieken
M. Bischof
K. Lindel
S.E. Combs
J. Debus
Publication date
01-01-2014
Publisher
Springer Berlin Heidelberg
Published in
Strahlentherapie und Onkologie / Issue 1/2014
Print ISSN: 0179-7158
Electronic ISSN: 1439-099X
DOI
https://doi.org/10.1007/s00066-013-0431-1

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