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Diagnostic Pathology
Published in: Diagnostic Pathology 1/2016

Open Access 01-12-2016 | Review

Surgical and molecular pathology of pancreatic neoplasms

Authors: Wenzel M. Hackeng, Ralph H. Hruban, G. Johan A. Offerhaus, Lodewijk A. A. Brosens

Published in: Diagnostic Pathology | Issue 1/2016

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Abstract

Background

Histologic characteristics have proven to be very useful for classifying different types of tumors of the pancreas. As a result, the major tumor types in the pancreas have long been classified based on their microscopic appearance.

Main body

Recent advances in whole exome sequencing, gene expression profiling, and knowledge of tumorigenic pathways have deepened our understanding of the underlying biology of pancreatic neoplasia. These advances have not only confirmed the traditional histologic classification system, but also opened new doors to early diagnosis and targeted treatment.

Conclusion

This review discusses the histopathology, genetic and epigenetic alterations and potential treatment targets of the five major malignant pancreatic tumors - pancreatic ductal adenocarcinoma, pancreatic neuroendocrine tumor, solid-pseudopapillary neoplasm, acinar cell carcinoma and pancreatoblastoma.
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Metadata
Title
Surgical and molecular pathology of pancreatic neoplasms
Authors
Wenzel M. Hackeng
Ralph H. Hruban
G. Johan A. Offerhaus
Lodewijk A. A. Brosens
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Diagnostic Pathology / Issue 1/2016
Electronic ISSN: 1746-1596
DOI
https://doi.org/10.1186/s13000-016-0497-z

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