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Journal of Gastrointestinal Surgery

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Open Access 01-12-2011 | Case Report

“Surgical” Abdomen in a Patient with Chronic Lymphocytic Leukemia: A Case of Acquired Angioedema

Authors: Moonjung Jung, Lawrence Rice

Published in: Journal of Gastrointestinal Surgery | Issue 12/2011

Abstract

Introduction

Acquired angioedema (AAE), an acquired deficiency of C1esterase inhibitor, is a medically treatable condition which can cause severe abdominal pain mimicking an acute surgical abdomen. This disorder is strongly associated with chronic lymphocytic leukemia (CLL) and other indolent lymphoplasmacytic disorders.

Discussion

We describe a patient with known CLL who developed incapacitating, recurrent severe abdominal pains, culminating in partial bowel resection. Signs, symptoms, laboratory and pathologic findings demonstrated AAE.

Conclusion

Wider appreciation of the possibility of AAE, particularly in patients with lymphoproliferative disorders, could lead to preventive therapy and spare unnecessary surgery. This is more important now that more effective medical therapies are available.

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Castelli R, Deliliers DL, et al. Lymphoproliferative disease and acquired C1 inhibitor deficiency. Hematologica/the hematology journal. 2007;92:5:716–718.CrossRef

Jung M, Rice L. Unusual autoimmune non-hematologic complications in chronic lymphocytic leukemia. Clin Lymphoma Myeloma Leuk. 2011 (In press).

Zuraw BL, Busse PJ, White M, et al. Nanofiltered C1 inhibitor concentrate for treatment of hereditary angiodedma. N Engl J Med. 2010;262:513–22.CrossRef

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Title: “Surgical” Abdomen in a Patient with Chronic Lymphocytic Leukemia: A Case of Acquired Angioedema
Authors: Moonjung Jung
Lawrence Rice
Publication date: 01-12-2011
Publisher: Springer-Verlag
Published in: Journal of Gastrointestinal Surgery / Issue 12/2011
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI: https://doi.org/10.1007/s11605-011-1718-0

At a glance: The STEP trials

Springer Medicine

“Surgical” Abdomen in a Patient with Chronic Lymphocytic Leukemia: A Case of Acquired Angioedema

Abstract

Introduction

Discussion

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Introduction

Discussion

Conclusion

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