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01-07-2012 | Original paper

Sun exposure and risk of lymphoid neoplasms in Singapore

Authors: Kin-Yoke Wong, Bee-Choo Tai, Sin-Eng Chia, Ponnudurai Kuperan, Khai-Mun Lee, Soon-Thye Lim, Susan Loong, Benjamin Mow, Siok-Bian Ng, Leonard Tan, Soo-Yong Tan, Suat-Hoon Tan, Miriam Tao, Alvin Wong, Gee-Chuan Wong, Adeline Seow

Published in: Cancer Causes & Control | Issue 7/2012

Abstract

Background

Epidemiologic studies have reported an inverse association between sun exposure and non-Hodgkin lymphoma (NHL), but these have been almost exclusively conducted in Western populations residing in temperate locations. We evaluated the association between personal outdoor sun exposure and risk of malignant lymphomas in Singapore.

Methods

A hospital-based case–control study of 541 incident cases of lymphoid neoplasms and 830 controls were recruited during 2004–2008. Participants were interviewed regarding recreational or occupational outdoor activities during childhood and in adulthood. Basic demographics and potential confounders were also collected. Odds ratios (OR) and 95 % confidence intervals (CI) were calculated using unconditional logistic regression analysis.

Results

Compared with individuals who did not have regular sun exposure, a lower risk of NHL was observed for those who reported regular exposure on non-school days during childhood [OR, 0.62; 95 % CI, 0.46–0.83] and non-working days in adulthood [OR, 0.70; 95 % CI, 0.51–0.97]. The protective effect was more evident among women.

Conclusion

Our findings support an inverse relationship between intermittent sun exposure and the risk of NHL. These findings are consistent with the growing evidence from various countries, but further studies, especially prospective studies, are needed in Asian populations.

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Title: Sun exposure and risk of lymphoid neoplasms in Singapore
Authors: Kin-Yoke Wong
Bee-Choo Tai
Sin-Eng Chia
Ponnudurai Kuperan
Khai-Mun Lee
Soon-Thye Lim
Susan Loong
Benjamin Mow
Siok-Bian Ng
Leonard Tan
Soo-Yong Tan
Suat-Hoon Tan
Miriam Tao
Alvin Wong
Gee-Chuan Wong
Adeline Seow
Publication date: 01-07-2012
Publisher: Springer Netherlands
Published in: Cancer Causes & Control / Issue 7/2012
Print ISSN: 0957-5243
Electronic ISSN: 1573-7225
DOI: https://doi.org/10.1007/s10552-012-9974-1

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Abstract

Background

Methods

Results

Conclusion

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