Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
Critical Care
Published in: Critical Care 1/2011

Open Access 01-02-2011 | Poster presentation

Sulfonated immunoglobulin improves cardiopulmonary functions by promoting IGF-I production in ARDS patients with severe sepsis

Authors: Y Deguchi, H Suga, T Sato, N Harada, T Nakagawa, K Okajima

Published in: Critical Care | Special Issue 1/2011

Login to get access

Excerpt

It has been emphasized that severe sepsis often leads to shock and ARDS in critically ill patients. We reported previously that sulfonated immunoglobulin (sIG) administration significantly inhibited the increase of in lung MPO activities and the increase of pulmonary vascular permeability. In the present study, we examined whether sIG improves not only ARDS but also cardiovascular dysfunction in patients with severe sepsis. …
Literature
1.
Okajima K, et al.: Activation of sensory neurons may contribute to reduction of endotoxin-induced hypotension by releasing CGRP, which is capable of promoting endothelial production of prostacyclin. Crit Care Med 2005, 33: 847-854. 10.1097/01.CCM.0000159721.72629.49CrossRefPubMed
2.
Harada N, et al.: Capsaicin-induced sensory neuron activation, which leads to release of CGRP, might increase IGF-I production, thereby reducing reperfusion-induced liver injury by reducing apoptosis. Neuropharmacology 2007, 52: 1303-1311. 10.1016/j.neuropharm.2007.01.016CrossRefPubMed
3.
Asakura H, et al.: Plasma levels of TNF and IL-6 could be significantly suppressed by immunoglobulin in the LPS-induced DIC model. Moreover, hemostatic abnormality, organ dysfunction, and glomerular fibrin deposition in this model were all ameliorated by immunoglobulin. Crit Care Med 2006, 34: 2421-2425. 10.1097/01.CCM.0000230382.38989.4FCrossRefPubMed
4.
Harada N, et al.: Stimulation of FcγRI on primary sensory neurons increases insulin-like growth factor-I production, thereby reducing reperfusion-induced renal injury in mice. J Immunol 2010, 185: 1303-1310. 10.4049/jimmunol.0902051CrossRefPubMed
Metadata
Title
Sulfonated immunoglobulin improves cardiopulmonary functions by promoting IGF-I production in ARDS patients with severe sepsis
Authors
Y Deguchi
H Suga
T Sato
N Harada
T Nakagawa
K Okajima
Publication date
01-02-2011
Publisher
BioMed Central
Published in
Critical Care / Issue Special Issue 1/2011
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc9838

Other articles of this Special Issue 1/2011

Critical Care 1/2011 Go to the issue

Poster presentation

Delta central venous pressure and dynamic indices of preload in postsurgical ICU patients

Poster presentation

Red blood cell transfusion thresholds in pediatric septic patients

Poster presentation

Daily physiological goal-setting: medical prescription and nursing adherence in a London teaching hospital ICU

Poster presentation

Influence of body mass index on the innate immune response during human endotoxemia

Poster presentation

Dynamics of peripheral perfusion parameters in elective coronary artery bypass graft patients

Poster presentation

Alarm performance in a novel continuous glucose monitor