Skip to main content
Top
Published in: Journal of Medical Case Reports 1/2010

Open Access 01-12-2010 | Case report

Successfully treated synchronous double malignancy of the breast and esophagus: a case report

Authors: Abhishek Singh, Ishwar Chandra Khare, Awadhesh Kumar Dixit, Kailash Chandra Pandey, Deepak Kumar Mittal, Parul Singh

Published in: Journal of Medical Case Reports | Issue 1/2010

Login to get access

Abstract

Introduction

The incidence of multiple primary cancers is reported to be between 0.3% and 4.3%. The second primary lesion is identified either simultaneously with the primary lesion (synchronous) or after a period of time (metachronous). Few cases of metastasis of breast carcinoma to the esophagus and vice versa have been reported in the past.

Case presentation

We report an extremely rare case of a 55-year-old Indian woman who had carcinomas in both the esophagus and the breast simultaneously. She was treated successfully using combined modalities of surgery, chemotherapy and radiation therapy.

Conclusion

Cases of synchronous double malignancies can be treated by dealing with the malignancy in the two sites as independent carcinomas. We have to take into consideration the total dose of radiation to a critical organ as well as the effect of the total dose of toxic chemotherapeutic drugs on our patient.
Appendix
Available only for authorised users
Literature
1.
go back to reference Slaughter DP, Southwick HW, Smejkal W: Field cancerization in oral stratified squamous epithelium: clinical implications of multicentric origin. Cancer. 1953, 6: 963-968. 10.1002/1097-0142(195309)6:5<963::AID-CNCR2820060515>3.0.CO;2-Q.CrossRefPubMed Slaughter DP, Southwick HW, Smejkal W: Field cancerization in oral stratified squamous epithelium: clinical implications of multicentric origin. Cancer. 1953, 6: 963-968. 10.1002/1097-0142(195309)6:5<963::AID-CNCR2820060515>3.0.CO;2-Q.CrossRefPubMed
2.
go back to reference Kagei K, Hosokawa M, Shirato H, Kusumi T, Shimizu Y, Watanabe A, Ueda M: Efficacy of intense screening and treatment for synchronous second primary cancers in patients with esophageal cancer. Jpn J Clin Oncol. 2002, 32: 120-127. 10.1093/jjco/hyf028.CrossRefPubMed Kagei K, Hosokawa M, Shirato H, Kusumi T, Shimizu Y, Watanabe A, Ueda M: Efficacy of intense screening and treatment for synchronous second primary cancers in patients with esophageal cancer. Jpn J Clin Oncol. 2002, 32: 120-127. 10.1093/jjco/hyf028.CrossRefPubMed
3.
go back to reference Voormolen MHJ, Van Deelen RAJ, Tilanus HW, van Lanschot JJB: Esophageal carcinoma and multiple primary tumors. Dis Esophagus. 1995, 8: 218-221. Voormolen MHJ, Van Deelen RAJ, Tilanus HW, van Lanschot JJB: Esophageal carcinoma and multiple primary tumors. Dis Esophagus. 1995, 8: 218-221.
4.
go back to reference Kumagai Y, Kawano T, Nakajima Y, Nagai K, Inoue H, Nara S, Iwai T: Multiple primary cancers associated with esophageal carcinoma. Surg Today. 2001, 31: 872-876. 10.1007/s005950170025.CrossRefPubMed Kumagai Y, Kawano T, Nakajima Y, Nagai K, Inoue H, Nara S, Iwai T: Multiple primary cancers associated with esophageal carcinoma. Surg Today. 2001, 31: 872-876. 10.1007/s005950170025.CrossRefPubMed
5.
go back to reference Nagasawa S, Onda M, Sasajima K, Takubo K, Miyashita M: Multiple primary malignant neoplasms in patients with esophageal cancer. Dis Esophagus. 2000, 13: 226-230. 10.1046/j.1442-2050.2000.00116.x.CrossRefPubMed Nagasawa S, Onda M, Sasajima K, Takubo K, Miyashita M: Multiple primary malignant neoplasms in patients with esophageal cancer. Dis Esophagus. 2000, 13: 226-230. 10.1046/j.1442-2050.2000.00116.x.CrossRefPubMed
6.
go back to reference Ahsan H, Neugut AI, Gammon MD: Association of adenocarcinoma and squamous cell carcinoma of the esophagus with tobacco-related and other malignancies. Cancer Epidemiol Biomarkers Prev. 1997, 6 (10): 779-782.PubMed Ahsan H, Neugut AI, Gammon MD: Association of adenocarcinoma and squamous cell carcinoma of the esophagus with tobacco-related and other malignancies. Cancer Epidemiol Biomarkers Prev. 1997, 6 (10): 779-782.PubMed
7.
go back to reference Holyoke ED, Nemoto T, Dao TL: Esophageal metastasis and dysphagia in patients with carcinoma of the breast. J Surg Oncol. 1969, 1 (2): 97-107. 10.1002/jso.2930010202.CrossRefPubMed Holyoke ED, Nemoto T, Dao TL: Esophageal metastasis and dysphagia in patients with carcinoma of the breast. J Surg Oncol. 1969, 1 (2): 97-107. 10.1002/jso.2930010202.CrossRefPubMed
8.
go back to reference Suzuki S, Nishimaki T, Suzuki T, Kanda T, Nakagawa S, Hatakeyama K: Outcomes of simultaneous resection of synchronous esophageal and extraesophageal carcinomas. J Am Coll Surg. 2002, 195: 23-29. 10.1016/S1072-7515(02)01147-X.CrossRefPubMed Suzuki S, Nishimaki T, Suzuki T, Kanda T, Nakagawa S, Hatakeyama K: Outcomes of simultaneous resection of synchronous esophageal and extraesophageal carcinomas. J Am Coll Surg. 2002, 195: 23-29. 10.1016/S1072-7515(02)01147-X.CrossRefPubMed
9.
go back to reference Van der Sijp JR, van Meerbeeck JP, Maat AP, Zondervan PE, Sleddens HF, van Geel AN, Eggermont AM, Dinjens WN: Determination of the molecular relationship between multiple tumors within one patient is of clinical importance. J Clin Oncol. 2002, 20: 1105-1114. 10.1200/JCO.20.4.1105.CrossRefPubMed Van der Sijp JR, van Meerbeeck JP, Maat AP, Zondervan PE, Sleddens HF, van Geel AN, Eggermont AM, Dinjens WN: Determination of the molecular relationship between multiple tumors within one patient is of clinical importance. J Clin Oncol. 2002, 20: 1105-1114. 10.1200/JCO.20.4.1105.CrossRefPubMed
10.
go back to reference Morris HL, da Silva AF: Co-existing abdominal aortic aneurysm and intraabdominal malignancy: reflections on the order of treatment. Br J Surg. 1998, 85: 1185-1190. 10.1046/j.1365-2168.1998.00852.x.CrossRefPubMed Morris HL, da Silva AF: Co-existing abdominal aortic aneurysm and intraabdominal malignancy: reflections on the order of treatment. Br J Surg. 1998, 85: 1185-1190. 10.1046/j.1365-2168.1998.00852.x.CrossRefPubMed
Metadata
Title
Successfully treated synchronous double malignancy of the breast and esophagus: a case report
Authors
Abhishek Singh
Ishwar Chandra Khare
Awadhesh Kumar Dixit
Kailash Chandra Pandey
Deepak Kumar Mittal
Parul Singh
Publication date
01-12-2010
Publisher
BioMed Central
Published in
Journal of Medical Case Reports / Issue 1/2010
Electronic ISSN: 1752-1947
DOI
https://doi.org/10.1186/1752-1947-4-169

Other articles of this Issue 1/2010

Journal of Medical Case Reports 1/2010 Go to the issue